Project information
Project manager
Pär Wanby
Other project members
Karin Mathold, Linköping University, Region Kalmar län; Martin Carlsson, Linnaeus University; Lars Brudin, Linköping University, Region Kalmar län.
Participating organizations
Linnaeus University; Region Kalmar län; Linköping University
Financier
Kalmar County Counsil
Timetable
Jun 2022–Jun 2026
Subject
Medicine (Department of Medicine and Optometry, Faculty of Health and Life Sciences)
More about the project
There are probably common mechanisms behind atherosclerosis and bone turnover. Cells similar to bone cells and have been found in atherosclerotic plaques but the exact actions of these cells are not known. We have chosen to study the five bone turnover markers osteocalcin (OCN), osteoprotegerin (OPG), osteopontin (OPN), dickkopf-1 (Dkk-1) and sclerostin in patients with suspected coronary artery disease. We measure blood levels of bone turnover markers in patients referred to myocardial perfusion scintigraphy with exercise test.
Our scientific hypothesis is that patients with signs of myocardial ischemia during the test also exhibit aberrant levels of bone turnover markers in the blood. Blood samples are drawn before the examination and at maximum effort. We also measure Troponin T which is a blood test related to myocardial ischemia. Bone density is also measured. Data are finally analysed regarding possible correlations between cardiac ischemia during the examination and the levels of bone turnover markers in the blood.
Staff
