The research activities of the Bioorganic and Biophysical Chemistry Laboratory fall into the following areas:
- The design, synthesis and evaluation of novel synthetic recognition systems. The study of molecular imprinting is an important aspect of our work in this area and the knowledge gained is being used for the development of mimics of enzymes and antibodies for applications in synthetic organic chemistry, biotechnology and clinical research.
- Fundamental studies in molecular recognition involving the thermodynamic characterisation of ligand - receptor binding events.
- The application of combinatorial chemistry and biology to the identification of new recognition elements.
- The study of microbiological and biomacromolecular stability and viability in chemically and physically extreme environments.
- Bionanotechnology: molecular motors. The study and application of motor protein function on micro and nano-scales.
- The development and use of spectroscopic methods for the study of synthetic and biological recognition systems.
Our research is performed in modern laboratories and we are equipped with, or have direct access to:
- Spectroscopy: NMR (500 MHz, Varian), fluorescence (3 instruments, including TIRF and stop-flow), UV, FT-IR, MS (MALDI-TOF)
- Molecular modelling: 32 core cluster with software for molecular dynamics (Amber, ver. 10, Gromacs, ver. 4.0), DFT (Siesta, ver. 2.0.2) and visualisation (VMD, ver. 1.8.6, Molekel, ver. 4.3)
- Microscopy: SEM, confocal fluorescence, AFM (nQuip), FT-IR
- Chromatography: HPLC (several), LC-MS, GC-MS, CE/CEC, FPLC
- Sensor platforms: SPR (Biacore X), QCM (Attana Cell-200, Attana-100, Attana-80)
- Miscellaneous: Isotope labs & scintillation counting, cell and virus culture labs, cell counter, flow cytometry, goniometry, viscosometry, dielectric constant meter
Granting agencies and industrial partners
Our research is run with the support of a number of granting agencies and industrial partners:
- The Swedish Research Council (Vetenskapsrådet; VR)
- The Carl Trygger Foundation (in Swedish)
- The Crafoord Foundation
- The Royal Swedish Academy of Sciences (Kungliga Vetenskapsakademien; KVA)
- The Knowledge Foundation (KK-stiftelsen; KKS)
The BBCL research group is part of the Department of Chemistry and Biomedical Sciences and the Linnæus University Centre of Excellence (LNUC) for Biomaterials Chemistry.
The majority of the people in BBCL contribute to the teaching activities at the Faculty of Health and Life Sciences. Members of the group have significant involvement in the teaching of undergraduate courses in:
- General Chemistry
- Inorganic Chemistry
- Organic Chemistry
- Physical Chemistry
- Analytical Chemistry
- Medicinal Chemistry
- Bioorganic Chemistry
- Laboratory methodology
These courses are integral components of a number of degree programmes:
- Biomedical Chemistry
- Biomedical Laboratory Science
- Environmental Management
- Nutrition and Food Science
- Teacher Education.
In addition, members of the team contribute to a range of PhD courses offered by the faculty.
Welcome to our seminars that take place Fridays at 2:30-3:30 in room N218 and are in English, unless otherwise stated.
Jan 22 MSc & BSc examination project presentations & MSc half-time reports
Jan 29 MSc & BSc examination project presentations & MSc half-time reports
Feb 5 Subban Kathirivan*
Feb 12 No seminar
Feb 19 Gustaf Olsson*
Feb 26 Maria Canterella, University of Catania, Italy*
March 4 Antoine Buetti-Dinh*
March 11 Kristina Magnusson
March 18 Kerstin Golker*
March 25 Easter
April 1 Research Council application writing
April 8 Natacha Ndizeye*
April 15 Swapnil Chavan* – thesis defence (preliminary)
April 22 Bengt Persson*
April 29 Helena Vandesande
May 6 Squeeze day holiday
May 13 Alf Månsson
May 19 Peter Lewis – thesis defence (preliminary)
May 20 Akademisk högtid
May 27 Daniel Fernando – thesis defence (preliminary)
May 31-June 3 BSc & MSc examination project presentations & graduation ceremony
June 10 LNUC–BMC workshop open lectures – to be announced
June 17 Xiaofen Wu – thesis defence (preliminary)
Lecture titles should be posted by the presenter (or their host) on the staff room information board.
* = LNUC–BMC colloquium
- Gustaf Olsson Research engineer
- Håkan Andersson Senior lecturer
- Ian Nicholls Professor, Dean
- Jesper Wiklander Research engineer
- Johan Rosengren Research Assistant
- Kathiravan Suppan Postdoctoral research fellow
- Kerstin Sandholm Lecturer
- Rashmi Mahajan Doctoral student
- Subramanian Suriyanarayanan Researcher
MSc student [January, 2016]
Shangquin Zhao, joined us to undertake his MSc thesis studies.
Visiting students [January 25, 2016]
Maria Canterella, University of Catania, Italy, joined us as a as part of the 7th Framework and ERASMUS programs. Alina Sklad, University of Saskatchewan, Canada, joined us for a half year long secondment.
BBCL 20 year anniversary symposium [December 10-11, 2015]
More than 25 past and current staff, students and visiting academics provided insights into a broad range of chemical science spanning from the modeling of chemical processes in our atmosphere to the development of strategies for detecting new illicit drugs and even drug development. The open lectures were well attended by other staff and students.
Visiting student [April, 2015]
Magda Switnicka-Plak, University of Strathclyde, UK, joined us as a short-term secondment fellow with the 7th Framework ITN PEPMIP.
Dissertation [January 30, 2015]
Gustaf Olsson successfully defended his PhD thesis entitled "Modelling of Molecular Interactions in Mixtures: Fundamental Studies and Applications".
Dissertation [October 31, 2014]
Louise Elmlund successfully defended her PhD thesis entitled "QCM-Based Sensing Using Biological and Biomimetic Interfaces".
Research grant awarded [October 24, 2014]
The Swedish Research Council (VR) has awarded the group 3.48 mSEK for 2015-2018 for the project "From Eutectic Mixtures to Hierarchical Material Architectures: Fundamental Studies and Applications".
Visiting student [October 2014]
Celina Wierzbicka, Dortmund Technical University, DE, joined us as a short secondment fellow within the 7th Framework ITN PEPMIP.
Dissertation [June 17, 2014]
Kerstin Golker successfully defended her PhD thesis entitled "Fundamental Studies on Molecularly Imprinted Materials".
Conference grant [May 23, 2014]
Kathiravan Suppan has recieved SEK 15,000 from Ångpanneföreningens Forskningsstiftelse to attend the 2nd International Symposium on C-H Activation, June 30-July 3 2014, Rennes, France. Congratulations!
Dissertation [May 9, 2014]
Siamak Shoravi successfully defended his PhD thesis entitled "Towards Rational Molecularly Imprinted Polymer Design Using Molecular Dynamics-Based Strategies".
Conference grants [November 8, 2013]
Louise Elmlund (PhD student in chemistry) has recieved three grants for participation in international conferences in SanDiego (USA) and Melbourne (Australia) during the months to follow. The grants (totalling 56 700 SEK) were awarded by Stiftelsen Sigurd och Elsa Goljes Minne, Sixten Gemzéus stiftelse/Gålöstiftelsen och Bröstcancerföreningarnas riksorganisation (BRO). Congratulations!
Dissertation [October 25, 2013]
Pernilla Söderberg successfully defended her PhD thesis entitled "Towards Novel Applications for Biomolecular Interactions at Surfaces".
MSc defense [June 3, 2013]
Natacha Ndizeye successfully defended her MSc thesis entitled "Green Solvents as Structure-Directing Agents in Imprinted Polymers".
Upcoming conference [May 23, 2013]
Ian Nicholls is a member of the international organising committee for Environmental ChemOinformatics (ECO) conference in Prien am Chiemsee, Germany, 15-18 September 2013.
Paper accepted [November 4, 2011]
Gustavs paper "Mechanisms Underlying Molecularly Imprinted Polymer Molecular Memory and The Role of Crosslinker: Resolving Debate on the Nature of Template Recognition in Phenylalanine Anilide Imprinted Polymers" has been accepted for publication in Journal of Molecular Recognition. Congratulations!
2 papers accepted [September 30, 2011]
Henning Henschel has two papers accepted within a week - congratulations!
New MSc students [August 29, 2011]
We welcome four new MSc students who have joined us for their 12 month MSc research projects: Younes Abghoui, Javed Hussain, Azalia Mostofi, Hazrat Nawaz.
Dissertation [June 10, 2011]
Henning Henschel has successfully defended his thesis entitled "Towards Macromolecular Systems for Catalysis". Faculty opponent was docent Ebbe Nordlander, Lund University.
EU-exchange [May 31, 2011]
Cinzia Passini, PhD student at the University of Turin in Italy, shall spend 4 months in the laboratory working on developing nanostructured surfaces for capillary electrophoresis.
Lecture [May 8, 2011]
Ian Nicholls shall present a keynote lecture at the Protein Engineering Summit (Boston, USA, May 9-13).
Lecture [March 22, 2011]
Ian Nicholls shall present a plenary lecture at the Drug Discovery Summit (Cannes, France, March 23-26).
4 papers accepted [March 5, 2011]
Four papers were accepted for publication this week: two in Analytical & Bioanalytical Chemistry and two in Biochemical & Biophysical Research Communications.
Examination project work [March 2, 2011]
Tobias Andersson has presented and defended his examination project work in pharmacy.
9M awarded [March 1, 2011]
The Knowledge Foundation and our industry partners Attana AB and Biomotif AB will support the project "Ultrasensitive bioanalysis using biomimetic recognition elements" with SEK 9M during 2011 and 2012. The project is headed by Professor Ian A Nicholls and Dr Jesper G Wiklander and aims at developing smart materials for ultrasensitive analyses by combining molecularly imprinted polymers with QCM and mass spectrometry.
Strategy meeting [February 28, 2011]
On February 25th, the BBCL annual strategy meeting was organised. The title was "Biomaterials Chemistry - current and future goals" and the meeting had 32 participants from 7 countries (from both academia and industry).
Paper published [February 20, 2011]
Björn Karlsson and Annika Rosengren have published a paper entitled "Spectroscopic evidence for the presence of the cyclic hemiketal form of warfarin in aqueous solution: Consequences for bioavailability" in Biochemical and Biophysical Research Communications.
Invited lecture [February 1, 2011]
Ian Nicholls (invited lecturer and co-presenter) shall present strategic and technical developments aimed to both understand and combat zoonotic diseases (One Health, Melbourne, Australia, February 14-16).
International Year of Chemistry
The BBCL is actively engaged in a series of activities at local, national and international levels to commemorate the "International Year of Chemistry".
Award from the Knowledge Foundation [December 21, 2010]
The Knowledge Foundation has awarded SEK 4 480 000 to the project "Ultrasensitive bioanalysis using biomimetic recognition elements" in collaboration with Attana AB and Biomotif AB.
Examination project award [November 19, 2010]
Gustaf Olsson was awarded SEK 50 000 by Sparbanksstiftelsen Kronan for his examination project "Fundamental Studies of Molecular Interactions in Complete Prepolymerization Mixtures of Molecularly Imprinted Polymers".
Conference in Copenhagen [September 15, 2010]
Linda and Louise attended the 31:st European Peptide Symposium in Copenhagen on September 5-9.
Conference in Lund [August 30, 2010]
Members of the group have participated at the 8:th European Conference on Computational Chemistry in Lund on August 25-28 (4 contributions).
MIP 2010 - New Orleans [August 17, 2010]
Members of the group attended the 6:th International Conference on Molecular Imprinting in New Orleans on August 9-12 (8 contributions). Gustaf Olsson won the best poster award.
Organic- and analytical chemistry meetings [July 6, 2010]
Members of the group have participated at the 22:nd Swedish Organic Chemistry Meeting (Organikerdagarna) in Uppsala on June 13-16 (5 contributions) and the 19:th Swedish Analytical Chemistry Meeting (Analytikerdagarna) in Uppsala on June 14-16 (2 contributions).
Grant from the Craaford Foundation [July 1, 2010]
Ian Nicholls has been awarded SEK 275 000 for advanced sensor studies.
Paper accepted for publication [June 15, 2010]
The research article "Warfarin: an environment-dependent switchable molecular probe" has been accepted for publication in the Journal of Molecular Recognition.
Examination project work [June 4, 2010]
Erika Nilsson successfully presented and defended her examination project work "Selective Recognition of Oseltamivir Imprinted Polymers".
Examination project work [April 30, 2010]
Nina Klasson successfully presented and defended her examination project work "Towards novel chromatographic stationary phases based upon adenine".
Examination project work [March 26, 2010]
Petronella Bergqvist successfully presented and defended her examination project work "Towards novel therapies and diagnostics: Studies of a novel polymer system".
Dissertation [December 11, 2009]
Jenny Rosengren-Holmberg successfully defended her thesis entitled "Molecular Imprinting: Design and Application of Biomimetic Polymers".
Grant from The Crafoord Foundation [November 30, 2009]
Ian Nicholls has been awarded SEK 1.9M for the purchase of state-of-the-art fluorescense equipment.
MSc thesis defence [November 12, 2009]
Gustaf Olsson and Johan Spanier have successfully defended their MSc theses.
Dissertation [November 6, 2009]
On November 6, Björn Karlsson successfully defended his thesis entitled "Structural Diversity in Molecularly Imprinted Polymers".
JACS paper [August 26, 2009]
The first all-component molecular dynamics study of a MIP prepolymerisation mixture has been published in the The Journal of the American Chemical Society.
VINNOVA grant [August 28, 2009]
Björn Karlsson, Annika Rosengren and Ian Nicholls were awarded SEK 200,000 from VINNOVA for commercialisation of a warfarin sensor.
EU project WATERMIM [May 25, 2009]
May 1 marked the official start of the EU-project WATERMIM and the kick-off meeting was held in Thessaloniki on May 22.
Dissertation [May 20, 2009]
On May 20, Annika Rosengren successfully defended her PhD thesis entitled "Characterisation of Ligand-Surface Interactions in Biomimetic Systems". Prof. Claudio Baggiani, University of Torino, Italy, was the faculty's opponent.
Propofol research in the news [January 15, 2009]
TV-appearance [December 5, 2008]
Pernilla Söderberg appeared on the Nobel Prize special of the TV quiz show "Who Knows Most?", Monday 1 December.
Dissertation [September 19, 2008]
On Sept 18, Miruna Petcu successfully defended her thesis entitled "Molecular Imprinting of an Anaesthetic Drug and Its Application to Real-Time Monitoring". Dr Richard Ansell, School of Chemistry, University of Leeds, UK, was the faculty's opponent.
Conference [September 12, 2008]
Björn CG Karlsson and Ian Nicholls presented posters and lectures at the fifth International Workshop on Molecular Imprinting on Sept 7-11 in Rokko Hall, Kobe University, Japan.
MSc thesis defence [June 4, 2008]
Louise Oskarsson has successfully defended her MSc thesis entitled "Quartz crystal microbalance study of protein-surface interactions".
Dissertation [May 22, 2008]
On May 22, Linus Olofsson successfully defended his thesis entitled "Biomolecular Structure and Function in Organic Solvents".
8M awarded [December 19, 2007]
The project "Novel Biosensors Based on the Attana QCM in conjunction with Electrocapture Technology and Molecularly Imprinted Polymers" was awarded SEK 8M over 3 years by The Knowledge Foundation (KK-stiftelsen) and our industry partners Attana AB and Biomotif AB.
Cover feature [October 23, 2007]
The paper "Mode of Heavy Meromyosin Adsorption and Motor Function Correlated with Surface Hydrophobicity and Charge" is now featured on the cover of the latest issue (Vol. 23, No. 22) of Langmuir.
MSc thesis defense [September 7, 2007]
Kajsa Yngvesson has successfully defended her MSc-thesis entitled "BOC-chemistry Solid Phase Peptide Synthesis of Four Taipan Natriuretic Peptides", supervised by Ian A. Nicholls in collaboration with Prof. Paul F. Alewood at the Institute for Molecular Bioscience, University of Queensland, Australia.
Contact and visiting information
Bioorganic and Biophysical Chemistry Laboratory
Linnaeus University Centre for Biomaterials Chemistry
Department of Chemistry and Biomedical Sciences
SE-391 82 Kalmar
Norra vägen 49, Kalmar
Fax: +46 (0)480–44 62 44
Phone: +46 (0)480–44 62 00 (operator)
By car: E22 from Copenhagen/Malmö/Lund, or E4 then E22 from Stockholm.
By train: Regular train services to/from Copenhagen Airport/Malmö/Lund, Gothenburg and Stockholm. We are located 1 km from the Central Station.
By air: Several flights to and from Stockholm each day with either SAS (Arlanda) or Kalmarflyg (Bromma). The airport is a 10 min drive from the Department.