Björn Karlsson
Associate Professor
Department of Chemistry and Biomedical Sciences
Faculty of Health and Life Sciences
+46480446740
45013, Hus Vita, Kalmar
Dear student or colleague!
My name is Björn C.G. Karlsson and I currently hold the position as a senior lecturer of physical chemistry and pharmacy at the Linnæus University. In 2013 I was awarded the title as an associate professor (docent) in physical chemistry.
Mobile number: +46 72-221 82 25
Teaching
To date I'm coordinating and having the role as an examiner for a series of undergraduate courses such as Organic Chemistry 7,5 credits (1KE010), Pharmaceutics 7,5 credits (1FA002) and Physical Chemistry 7,5 credits (1KE002). In addition to these courses on the undergraduate-level I'm also coordinating courses on the advanced level such as Research Methodology in the Natural Sciences 15 credits (4XN002), a course given to PhD-students and students on the Master-level. I currently also coordinating Computational Chemistry 3 credits, Molecular Spectroscopy 3 credits and Analytical Chemistry with a Focus on Biosensors 3 credits. All these three courses being sub-courses on the advanced-level course Current Pure and Applied Chemistry 15 credits (4KE003).
Research
My background is within the bioorganic and biophysical research field from which I've won experience in physical studies of drug molecules as well as polymeric materials. These systems have predominantly been studied by a series of theoretical methods based on quantum-mechanical ab-initio calculations and classical-mechanical molecular dynamics simulations. Experimental studies have in part been focused at polymer synthesis as well as physical characterization using molecular spectroscopic methods such as NMR-, FT-IR-, UV/Vis-absorption- and fluorescence spectroscopy (steady-state as well as time-resolved techniques).
My current research interests are multiple and I) focused to understand the mechanisms involved in the development of Parkinson's Disease, a project that is conducted in close-collaboration with Med Dr Thomas Näsström and in which we together are trying to find answers to the important questions on what causes a nerve cell to die and how a infected cell can spread the disease? II) In another project we are trying to understand the mechanisms involved and that can explain the selectivity displayed by the membrane proteins that belong to 'Major Facilitator Superfamily' (MFS) and that regulate the very important transport of nutrients in and out of our cells. This project is performed in close-collaboration with Professor Bengt Persson and Dr Dieter Samyn and that initially has been focused at studies on Pho84, a protein that regulates the transport of inorganic phosphate in Saccharomyces cerevisiae.
In my research I also have III) an interest in studies that shed light on fundamental physical-chemical questions as an example current research is being conducted trying to answer the question on how the molecular structure of small organic drug molecules affects their solubility as well as their evaporation from non-ideal mixtures, properties that are of importance for drug development and formulation.
To read more about my current research activities, please visit the Physical Pharmacy Laboratory (PPL) research group, see below.
My research groups
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Physical Pharmacy Laboratory We are using chemical and physical principles to study the molecular events underlying the development and design of pharmaceutics and their formulations.
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Linnaeus University Centre for Biomaterials Chemistry Linnaeus University Centre for Biomaterials Chemistry is a principal research environment at Linnaeus University that deals with the development…
Publications
Article in journal (Refereed)
- Näsström, T., Ådén, J., Shibata, F., Andersson, P.O., Karlsson, B.C.G. (2020). A Capped Peptide of the Aggregation Prone NAC 71–82 Amino Acid Stretch of α-Synuclein Folds into Soluble β-Sheet Oligomers at Low and Elevated Peptide Concentrations. International Journal of Molecular Sciences. 21. 1-14.
- Steinz, M.M., Persson, M., Aresh, B., Olsson, K., Cheng, A.J., et al. (2019). Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritis. JCI Insight. 4. 1-16.
- Näsström, T., Andersson, P.O., Lejon, C., Karlsson, B.C.G. (2019). Amyloid fibrils prepared using an acetylated and methyl amidated peptide model of the alpha-Synuclein NAC 71-82 amino acid stretch contain an additional cross-beta structure also found in prion proteins. Scientific Reports. 9. 1-14.
- Karlsson, B.C.G., Friedman, R. (2017). Dilution of whisky - the molecular perspective. Scientific Reports. 7.
- Samyn, D.R., van Der Veken, J., van Zeebroeck, G., Persson, B.L., Karlsson, B.C.G. (2016). Key Residues and Phosphate Release Routes in the Saccharomyces cerevisae Pho84 Transceptor - The Role of Tyr179 in Functional Regulation. Journal of Biological Chemistry. 291. 26388-26398.
- Shoravi, S., Olsson, G.D., Karlsson, B.C.G., Bexborn, F., Abghoui, Y., et al. (2016). In silico screening of molecular imprinting prepolymerization systems : oseltamivir selective polymers through full-system molecular dynamics-based studies. Organic and biomolecular chemistry. 14. 4210-4219.
- Olsson, G.D., Niedergall, K., Bach, M., Karlsson, B.C.G., Tovar, G., et al. (2015). Simulation of imprinted emulsion prepolymerization mixtures. Polymer journal. 47. 827-830.
- Golker, K., Karlsson, B.C.G., Wiklander, J.G., Rosengren, A.M., Nicholls, I.A. (2015). Hydrogen bond diversity in the pre-polymerization stage contributes to morphology and MIP-template recognition–MAA versus MMA. European Polymer Journal. 66. 558-568.
- Shoravi, S., Olsson, G.D., Karlsson, B.C.G., Nicholls, I.A. (2014). On the Influence of Crosslinker on Template Complexation in Molecularly Imprinted Polymers : A Computational Study of Prepolymerization Mixture Events with Correlations to Template-Polymer Recognition Behavior and NMR Spectroscopic Studies. International Journal of Molecular Sciences. 15. 10622-10634.
- Chavan, S., Nicholls, I.A., Karlsson, B.C.G., Rosengren, A.M., Ballabio, D., et al. (2014). Towards Global QSAR Model Building for Acute Toxicity : Munro Database Case Study. International Journal of Molecular Sciences. 15. 18162-18174.
- Golker, K., Karlsson, B.C.G., Rosengren, A.M., Nicholls, I.A. (2014). A Functional Monomer Is Not Enough : Principal Component Analysis of the Influence of Template Complexation in Pre-Polymerization Mixtures on Imprinted Polymer Recognition and Morphology. International Journal of Molecular Sciences. 15. 20572-20584.
- Cleland, D., Olsson, G.D., Karlsson, B.C.G., Nicholls, I.A., Mccluskey, A. (2014). Molecular dynamics approaches to the design and synthesis of PCB targeting molecularly imprinted polymers: interference to monomer-template interactions in imprinting of 1,2,3-trichlorobenzene. Organic and biomolecular chemistry. 12. 844-853.
- Nicholls, I.A., Karlsson, B.C.G., Olsson, G.D., Rosengren, A.M. (2013). Computational Strategies for the Design and Study of Molecularly Imprinted Materials. Industrial & Engineering Chemistry Research. 52. 13900-13909.
- Karlsson, B.C.G., Olsson, G.D., Friedman, R., Rosengren, A.M., Henschel, H., et al. (2013). How warfarin’s structural diversity influences its phospholipid bilayer membrane permeation. Journal of Physical Chemistry B. 117. 2384-2395.
- Rosengren, A.M., Karlsson, B.C.G., Nicholls, I.A. (2013). Consequences of morphology on molecularly imprinted polymer-ligand recognition. International Journal of Molecular Sciences. 14. 1207-1217.
- Golker, K., Karlsson, B.C.G., Olsson, G.D., Rosengren, A.M., Nicholls, I.A. (2013). Influence of composition and morphology on template recognition in molecularly imprinted polymers. Macromolecules. 46. 1408-1414.
- Olsson, G.D., Karlsson, B.C.G., Schillinger, E., Sellergren, B., Nicholls, I.A. (2013). Theoretical Studies of 17-beta-Estradiol-Imprinted Prepolymerization Mixtures : Insights Concerning the Roles of Cross-Linking and Functional Monomers in Template Complexation and Polymerization. Industrial & Engineering Chemistry Research. 52. 13965-13970.
- Rosengren, A.M., Karlsson, B.C.G., Nicholls, I.A. (2012). Monitoring of the distribution of warfarin in blood plasma. ACS Medicinal Chemistry Letters. 3. 650-652.
- Olsson, G.D., Karlsson, B.C.G., Shoravi, S., Wiklander, J.G., Nicholls, I.A. (2012). Mechanisms Underlying Molecularly Imprinted Polymer Molecular Memory and The Role of Crosslinker: Resolving Debate on the Nature of Template Recognition in Phenylalanine Anilide Imprinted Polymers. Journal of Molecular Recognition. 25. 69-73.
- Rosengren, A.M., Karlsson, B.C.G., Näslund, I., Andersson, P.O., Nicholls, I.A. (2011). In situ detection of warfarin using time-correlated single-photon counting.. Biochemical and Biophysical Research Communications - BBRC. 407. 60-62.
- Rosengren, A.M., Karlsson, B.C.G. (2011). Spectroscopic evidence for the presence of the cyclic hemiketal form of warfarinin aqueous solution: Consequences for bioavailability. Biochemical and Biophysical Research Communications - BBRC. 407. 318-320.
- Wiklander, J.G., Karlsson, B.C.G., Aastrup, T., Nicholls, I.A. (2011). Towards a synthetic avidin mimic. Analytical and Bioanalytical Chemistry. 400. 1397-1404.
- Karlsson, B.C.G., Rosengren, A.M., Näslund, I., Andersson, P.O., Nicholls, I.A. (2010). Synthetic Human Serum Albumin Sudlow I Binding Site Mimics. Journal of Medicinal Chemistry. 53. 7932-7937.
- Nicholls, I.A., Karlsson, B.C.G., Rosengren, A.M., Henschel, H. (2010). Warfarin: an environment-dependent switchable molecular probe. Journal of Molecular Recognition. 23. 604-608.
- Henschel, H., Karlsson, B.C.G., Rosengren, A.M., Nicholls, I.A. (2010). The Mechanistic Basis for Warfarin’s Structural Diversity and Implications for Its Bioavailability. Journal of Molecular Structure : THEOCHEM. 958. 7-9.
- Nicholls, I.A., Andersson, H.S., Charlton, C., Henschel, H., Karlsson, B.C.G., et al. (2009). Theoretical and Computational Strategies for Rational Molecularly Imprinted Polymer Design. Biosensors & bioelectronics. 25. 543-552.
- Karlsson, B.C.G., O'mahony, J., Karlsson, J.G., Bengtsson, H., Eriksson, L.A., et al. (2009). Structure and Dynamics of Monomer-Template Complexation: An Explanation for Molecularly Imprinted Polymer Recognition Site Heterogeneity. Journal of the American Chemical Society. 131. 13297-13304.
- Karlsson, B.C.G., Rosengren, A.M., Andersson, P., Nicholls, I.A. (2009). Molecular Insights on the Two Fluorescence Lifetimes Displayed by Warfarin from Fluorescence Anisotropy and Molecular Dynamics Studies. Journal of Physical Chemistry B. 113. 7945-7949.
- O'mahony, J., Karlsson, B.C.G., Mizaikoff, B., Nicholls, I.A. (2007). Correlated theoretical, spectroscopic and X-ray crystallographic studies of a non-covalent molecularly imprinted polymerisation system. The Analyst. 132. 1161-1168.
- Karlsson, B.C.G., Rosengren, A.M., Andersson, P., Nicholls, I.A. (2007). The Spectrophysics of Warfarin: Implications for Protein Binding. Journal of Physical Chemistry B. 111. 10520-10528.
- Karlsson, J.G., Karlsson, B.C.G., Andersson, L.I., Nicholls, I.A. (2004). The roles of template complexation and ligand binding conditions on recognition in bupivacaine molecularly imprinted polymers. Analyst. 129. 456-462.
Conference paper (Refereed)
- Nicholls, I.A., Shoravi, S., Orozovic, K., Olsson, G.D., Karlsson, B.C.G. (2011). Synthetic Neuraminidases : Nanostructured Materials for Environmental Monitoring. Ecohealth, vol. 7, Supplement 1. S97-S97.
- Karlsson, B.C.G., Rosengren, A.M., Näslund, I., Andersson, P.O., Nicholls, I.A. (2010). A molecularly imprinted polymer-based detection of Warfarin using time resolved fluorescence spectroscopy. .
- Rosengren, A.M., Karlsson, B.C.G., Nicholls, I.A. (2010). Morphology studies on warfarin imprinted polymers: the significance of the degree of crosslinking on polymer performance. .
- Golker, K., Karlsson, B.C.G., Olsson, G.D., Nicholls, I.A. (2010). Towards Molecular Dynamics-Based Rational Design of Synthetic Polymer Recognition Systems. .
- Golker, K., Karlsson, B.C.G., Olsson, G.D., Nicholls, I.A. (2010). Towards the use of molecular dynamics as a predictive tool in the design of molecularly imprinted polymers. .
- Olsson, G.D., Karlsson, B.C.G., Wiklander, J.G., Nicholls, I.A. (2010). Mechanism of Phenylalanine Anilide Molecularly Imprinted Polymer - Template Recognition: The Role of Template Dimerization. .
- Olsson, G.D., Karlsson, B.C.G., Wiklander, J.G., Shoravi, S., Nicholls, I.A. (2010). The nature and extent of interactions in phenylalanine anilide molecularly imprinted polymer prepolymerisation mixtures: a new model for the basis for ligand-selective recognition. .
- Shoravi, S., Orozovic, K., Karlsson, B.C.G., Wiklander, J.G., Nicholls, I.A. (2010). Towards Synthetic Neuraminidases. .
- Golker, K., Karlsson, B.C.G., Olsson, G.D., Nicholls, I.A. (2010). Towards Molecular Dynamics-Based Rational Design of Polymeric Recognition Systems. .
- Olsson, G.D., Karlsson, B.C.G., Wiklander, J.G., Shoravi, S., Nicholls, I.A. (2010). The Nature and Extent of Template-Template Complexation in Phenylalanine Anilide Molecularly Imprinted Polymers. .
- Wiklander, J.G., Karlsson, B.C.G., Aastrup, T., Nicholls, I.A. (2010). A synthetic polymer with avidin-like binding properties. .
- Henschel, H., Karlsson, B.C.G., Rosengren, A.M., Nicholls, I.A. (2010). Insights into the Isomerisation Mechanism of Warfarin. .
- Shoravi, S., Karlsson, B.C.G., Olsson, G.D., Nicholls, I.A. (2010). Molecular dynamics study of mechanisms underlying propranolol-mip molecular memory and the role of cross-linker. .
- Karlsson, B.C.G., Olsson, G.D., Rosengren, A.M., Nicholls, I.A. (2010). The Effect of Warfarin’s Structural Diversity on Permeation Across a DPPC Bilayer Membrane. .
- Rosengren, A.M., Karlsson, B.C.G., Näslund, I., Andersson, P.O., Nicholls, I.A. (2010). Time Resolved Fluorescence Spectroscopic Detection of the Anticoagulant Warfarin: A Sensor-based Method for Direct Detection in Blood-plasma. .
- Karlsson, B.C.G., Rosengren, A.M., Andersson, P., Nicholls, I.A. (2009). The spectrophysics of warfarin: Implications for protein binding. .
- Nicholls, I.A., Karlsson, B.C.G., Andersson, H.S., Golker, K., Henschel, H., et al. (2009). Biomimetic Polymer Design. .
- Karlsson, B.C.G., O'mahony, J., Karlsson, J.G., Bengtsson, H., Eriksson, L.A., et al. (2009). Structure and dynamics of monomer-template complexation: can molecularly imprinted polymer recognition site heterogeneity be explained?. .
- Karlsson, B.C.G., Rosengren, A.M., Andersson, P.O., Nicholls, I.A. (2009). The Spectrophysics of Warfarin. .
- Karlsson, B., Rosengren, A., Andersson, P., Nicholls, I.A. (2006). The role of isomerization on the spectroscopic properties of Warfarin. .
- Karlsson, B., Rosengren, A., Andersson, P., Nicholls, I.A. (2006). The role of isomerization on the spectroscopic properties of Warfarin. .
- O'mahony, J., Karlsson, B., Mizaikoff, B., Nicholls, I.A. (2006). Prior to polymerisation: Insights from correlated theoretical, solution phase and solid state studies. .
- O'mahony, J., Karlsson, B., Nicholls, I.A. (2006). Structure and dynamics of template-monomer complexation: An explanation for recognition site heterogeneity. .
- Karlsson, J.G., Karlsson, B., Andersson, L.I., Nicholls, I.A. (2004). The roles of template complexation and ligand binding conditions on recognition in bupivacaine molecularly imprinted polymers. .
Chapter in book (Refereed)
- Nicholls, I.A., Olsson, G.D., Karlsson, B.C.G., Suriyanarayanan, S., Wiklander, J.G. (2018). Theoretical and Computational Strategies in Molecularly Imprinted Polymer Development. Molecularly Imprinted Polymers for Analytical Chemistry Applications. London, Royal Society of Chemistry. 197-226.
- Nicholls, I.A., Chavan, S., Golker, K., Karlsson, B.C.G., Olsson, G.D., et al. (2015). Theoretical and Computational Strategies for the Study of the Molecular Imprinting Process and Polymer Performance. Molecularly Imprinted Polymers in Biotechnology. Berlin, Springer. 25-50.
- Nicholls, I.A., Andersson, H.S., Golker, K., Henschel, H., Karlsson, B.C.G., et al. (2013). Rational molecularly imprinted polymer design : theoretical and computational strategies. Molecular Imprinting : Principles and Applications of Micro- and Nanostructured Polymers. London, Pan Stanford Publishing. 71-104.
Article, review/survey (Refereed)
- Nicholls, I.A., Andersson, H.S., Golker, K., Henschel, H., Karlsson, B.C.G., et al. (2011). Rational Design of Biomimetic Molecularly Imprinted Materials: Theoretical and Computational Strategies for Guiding Nanoscale Structured Polymer Development. Analytical and Bioanalytical Chemistry. 400. 1771-1786.
Conference paper (Other academic)
- Karlsson, B., O'mahony, J., Karlsson, J.G., Bengtsson, H., Eriksson, L.A., et al. (2008). Structure and dynamics of monomer-template complexation: an explanation for molecularly imprinted polymer recognition site heterogeneity. .
Chapter in book (Other academic)
- Karlsson, B.C.G. (2013). Molekylmodellering. En litteraturstudie över dess användning i högre kemiutbildning. Universitetspedagogik i praktiken : Sexton lärartexter om pedagogisk utveckling. Växjö, Linnaeus University. 161-173.
Patent (Other (popular science, discussion, etc.))
- Nicholls, I.A., Karlsson, B.C.G., Rosengren, A.M., Andersson, P. (2014). Method and apparatus for detecting pharmaceuticals in a sample.
- Nicholls, I.A., Andersson, P., Karlsson, B.C.G., Rosengren, A.M. (2010). Method and apparatus for detecting pharmaceuticals in a sample.
- Nicholls, I.A., Andersson, P., Karlsson, B.C.G., Rosengren, A.M. (2009). Method and apparatus for detecting pharmaceuticals in a sample.