Dick Sjöström

Senior lecturer

Department of Chemistry and Biomedical Sciences Faculty of Health and Life Sciences

dick.sjostrom@lnu.se

+46 480-44 73 62

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Teaching

I am responsible for courses in physiology for pharmacists, biomedical analysts and biologists. I am mainly teaching in these courses, but am also involved in teaching other courses, such as general chemistry and biochemistry.

Research

My research interests are in the intersection of biochemistry and physiology, with a focus on elucidating physiological processes through protein design, engineering, and the development of innovative model systems.

I did my PhD in Sinisa Bjelic's research group, designing and engineering proteins binding partners of the transferrin receptor. We studied the binding protein of a hemorrhagic fever virus and started design of proteins for possible therapeutic use. We also designed novel proteins binding the receptor.

I did my postdoc in the Host Response to Biomaterials research group, where we studied thromboinflammation, with a particular interest in the complement system. My reserach included studying the biocompatibility of nanoparticles in a whole blood model containing endothelial cells, unraveling the complement system activation in postcovid and investigating the cross-talk between platelets and the complement system.

Publications

Article in journal (Refereed)

Grimaldi, M.C., Bozzer, S., Sjöström, D.J., Andersson, L., Mollnes, T.E., et al. (2025). DNA-loaded targeted nanoparticles as a safe platform to produce exogenous proteins in tumor B cells. Frontiers in Immunology. 15.
Status: Published
Andersson, L., Sjöström, D.J., Brandwijk, R.J., Toonen, E.J., Mollnes, T.E., et al. (2025). Complement function and activation in human serum and plasma collected in different blood collection tubes. JIM - Journal of Immunological Methods. 538.
Status: Published
Andersson, L., Sjöström, D.J., Quach, H.Q., Hägerström, K., Hurler, L., et al. (2024). Storage of Transfusion Platelet Concentrates is Associated with Complement Activation and Reduced Ability of Platelets to Respond to Protease-Activated Receptor-1 and Thromboxane A2 Receptor. International Journal of Molecular Sciences. 25 (2).
Status: Published
Sjöström, D.J., Grill, B., Ambrosetti, E., Veetil, A.A., Mohlin, C., et al. (2023). Affinity Maturated Transferrin Receptor Apical Domain Blocks Machupo Virus Glycoprotein Binding. Journal of Molecular Biology. 435 (20).
Status: Published
Gerogianni, A., Baas, L.M., Sjöström, D.J., Van De Kar, N.C.A.J., Pullen, M., et al. (2023). Functional evaluation of complement factor I variants by immunoassays and SDS-PAGE. Frontiers in Immunology. 14.
Status: Published
Gerogianni, A., Bal, M., Mohlin, C., Woodruff, T.M., Lambris, J.D., et al. (2023). In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model. Frontiers in Immunology. 14.
Status: Published
Sjöström, D.J., Mohlin, C., Ambrosetti, E., Garforth, S.J., Teixeira, A.I., et al. (2022). Motif-driven protein binder design towards transferrin receptor helical domain. The FEBS Journal. 289 (10). 2935-2947.
Status: Published
Sjöström, D.J., Lundgren, A., Garforth, S.J., Bjelic, S. (2021). Tuning the binding interface between Machupo virus glycoprotein and human transferrin receptor. Proteins : Structure, Function, and Bioinformatics. 89 (3). 311-321.
Status: Published
Sjöström, D.J., Berger, S.A., Oberdorfer, G., Bjelic, S. (2020). Computational backbone design enables soluble engineering of transferrin receptor apical domain. Proteins : Structure, Function, and Bioinformatics. 88 (12). 1569-1577.
Status: Published

Doctoral thesis, comprehensive summary (Other academic)

Sjöström, D.J. (2021). Design and engineering of human transferrin receptor 1 and its binding proteins. Doctoral Thesis. Växjö, Linnaeus University Press. 52.

Manuscript (preprint) (Other academic)

Gerogianni, A., Sørensen, G., Nilsen Hoel, T., Mcadam, K.E., Ludviksen, J.A., et al. Implantation of a continuous-flow left ventricular assist device is associated with a significant but transient acute thromboinflammatory response.