Kristina Nilsson-Ekdahl

Professor

Department of Chemistry and Biomedical Sciences Faculty of Health and Life Sciences

kristina.nilsson-ekdahl@lnu.se

Research

I have extensive experience in research on the regulation of native immunity, particularly when it comes to complement components, including a number of groundbreaking studies on platelet-mediated, extracellular phosphorylation of plasma proteins. My list of publications includes bridging research, covering everything from fundamental studies, e.g., the crystal structure of the complement component C3, to clinical studies of dysregulation of native immunity systems, e.g., at clinical transplantation of cell islets and autoimmunity. One main focus, that is of particular importance to the present application, is to identify mechanisms for unfavourable activation that takes place when there is contact between artificial biomaterials and human blood, and to develop new strategies to control these reactions.

My research groups

Linnaeus University Centre for Biomaterials Chemistry Linnaeus University Centre for Biomaterials Chemistry is a principal research environment that deals with the development and the adaptation of…

My ongoing research projects

Project: Do complement regulators control the pathophysiology of macular degeneration? The research project aims to investigate the effect of complement system regulators, mainly factor H, on the…

Publications

Article in journal (Refereed)

Lindelöf, L., Rantapää-Dahlqvist, S., Lundtoft, C., Sandling, J.K., Leonard, D., et al. (2024). A survey of ficolin-3 activity in Systemic Lupus Erythematosus reveals a link to hematological disease manifestations and autoantibody profile. Journal of Autoimmunity. 143.
Status: Published
Nilsson Ekdahl, K., Fromell, K., Mannes, M., Grinnemo, K., Huber-Lang, M., et al. (2023). Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop. Immunological Reviews. 313 (1). 91-103.
Status: Published
Huang, T., Sato, Y., Kuramochi, A., Ohba, Y., Sano, M., et al. (2023). Surface modulation of extracellular vesicles with cell-penetrating peptide-conjugated lipids for improvement of intracellular delivery to endothelial cells. Regenerative Therapy. 22. 90-98.
Status: Published
Lindelöf, L., Dahlqvist, S.R., Lundtoft, C., Nilsson Ekdahl, K., Nilsson, B., et al. (2023). 62 Acquired ficolin-3 deficiency in patients with Systemic Lupus Erythematosus. Immunobiology. 228 (5). 152515-152515.
Status: Published
Martin, M., Nilsson, S.C.C., Eikrem, D., Fromell, K., Scavenius, C., et al. (2023). Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis. Frontiers in Immunology. 14.
Status: Published
Spiegelburg, D.T., Mannes, M., Schultze, A., Scheibenberger, F., Mueller, F., et al. (2023). Impact of surface coating and systemic anticoagulants on hemostasis and inflammation in a human whole blood model. PLOS ONE. 18 (1).
Status: Published
Kokelj, S., Ostling, J., Fromell, K., Vanfleteren, L.E.G.W., Olsson, H.K., et al. (2023). Activation of the Complement and Coagulation Systems in the Small Airways in Asthma. Respiration. 102 (8). 621-631.
Status: Published
Nilsson, B., Eriksson, O., Fromell, K., Persson, B., Nilsson Ekdahl, K. (2023). How COVID-19 and other pathological conditions and medical treatments activate our intravascular innate immune system. Frontiers in Immunology. 13.
Status: Published
Mannes, M., Halbgebauer, R., Wohlgemuth, L., Messerer, D.A.C., Savukoski, S., et al. (2023). Combined Heterozygous Genetic Variations in Complement C2 and C8B : An Explanation for Multidimensional Immune Imbalance?. Journal of Innate Immunity. 15 (1). 412-427.
Status: Published
Adler, A., Fritsch, M., Fromell, K., Leneweit, G., Nilsson Ekdahl, K., et al. (2023). Regulation of the innate immune system by fragmented heparin-conjugated lipids on lipid bilayered membranes in vitro. Journal of materials chemistry. B. 11 (46). 11121-11134.
Status: Published
Adler, A., Inoue, Y., Nilsson Ekdahl, K., Baba, T., Ishihara, K., et al. (2022). Effect of liposome surface modification with water-soluble phospholipid polymer chain-conjugated lipids on interaction with human plasma proteins. Journal of materials chemistry. B. 10 (14). 2512-2522.
Status: Published
Adler, A., Manivel, V.A., Fromell, K., Teramura, Y., Nilsson Ekdahl, K., et al. (2022). A Robust Method to Store Complement C3 With Superior Ability to Maintain the Native Structure and Function of the Protein. Frontiers in Immunology. 13.
Status: Published
Wohlgemuth, L., Stratmann, A.E.P., Muennich, F., Bernhard, S., Thomass, B.D., et al. (2022). Modulation of Neutrophil Activity by Soluble Complement Cleavage Products-An In-Depth Analysis. Cells. 11 (20).
Status: Published
Suzuki, H., Adler, A., Huang, T., Kuramochi, A., Ohba, Y., et al. (2022). Impact of spontaneous liposome modification with phospholipid polymer-lipid conjugates on protein interactions. Science and Technology of Advanced Materials. 23 (1). 845-857.
Status: Published
Gerogianni, A., Dimitrov, J.D., Zarantonello, A., Poillerat, V., Chonat, S., et al. (2022). Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation. Frontiers in Immunology. 13.
Status: Published
Hultström, M., Frithiof, R., Grip, J., Lindelöf, L., Rooijackers, O., et al. (2022). Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Nature Immunology. 23. 861-864.
Status: Published
Lagedal, R., Eriksson, O., Sörman, A., Huckriede, J.B., Kristensen, B., et al. (2022). Impaired Antibody Response Is Associated with Histone-Release, Organ Dysfunction and Mortality in Critically Ill COVID-19 Patients. Journal of Clinical Medicine. 11 (12).
Status: Published
Kokelj, S., Ostling, J., Georgi, B., Fromell, K., Nilsson Ekdahl, K., et al. (2021). Smoking induces sex-specific changes in the small airway proteome. Respiratory Research. 22 (1).
Status: Published
Rangasami, V.K., Nawale, G., Asawa, K., Kadekar, S., Samanta, S., et al. (2021). Pluronic Micelle-Mediated Tissue Factor Silencing Enhances Hemocompatibility, Stemness, Differentiation Potential, and Paracrine Signaling of Mesenchymal Stem Cells. Biomacromolecules. 22 (5). 1980-1989.
Status: Published
Goto, J., Forsberg, U., Jonsson, P., Matsuda, K., Nilsson, B., et al. (2021). Interdialytic weight gain of less than 2.5% seems to limit cardiac damage during hemodialysis. International Journal of Artificial Organs. 44 (8). 539-550.
Status: Published
Adler, A., Inoue, Y., Sato, Y., Ishihara, K., Nilsson Ekdahl, K., et al. (2021). Synthesis of poly(2-methacryloyloxyethyl phosphorylcholine)-conjugated lipids and their characterization and surface properties of modified liposomes for protein interactions. Biomaterials Science. 9 (17). 5854-5867.
Status: Published
Lipcsey, M., Persson, B., Eriksson, O., Blom, A.M., Fromell, K., et al. (2021). The Outcome of Critically Ill COVID-19 Patients Is Linked to Thromboinflammation Dominated by the Kallikrein/Kinin System. Frontiers in Immunology. 12.
Status: Published
Mannes, M., Schmidt, C.Q., Nilsson, B., Nilsson Ekdahl, K., Huber-Lang, M. (2021). Complement as driver of systemic inflammation and organ failure in trauma, burn, and sepsis. Seminars in Immunopathology. 43. 773-788.
Status: Published
Bernhard, S., Hug, S., Stratmann, A.E.P., Erber, M., Vidoni, L., et al. (2021). Interleukin 8 Elicits Rapid Physiological Changes in Neutrophils That Are Altered by Inflammatory Conditions. Journal of Innate Immunity. 13. 225-241.
Status: Published
Asawa, K., Ishihara, K., Nilsson Ekdahl, K., Nilsson, B., Teramura, Y. (2021). Cell Surface Functionalization with Heparin-Conjugated Lipid to Suppress Blood Activation. Advanced Functional Materials. 31 (11).
Status: Published
Svensson, F.G., Manivel, V.A., Seisenbaeva, G.A., Kessler, V.G., Nilsson, B., et al. (2021). Hemocompatibility of Nanotitania-Nanocellulose Hybrid Materials. Nanomaterials. 11 (5).
Status: Published
Sato, Y., Asawa, K., Huang, T., Noiri, M., Nakamura, N., et al. (2021). Induction of Spontaneous Liposome Adsorption by Exogenous Surface Modification with Cell-Penetrating Peptide-Conjugated Lipids. Langmuir. 37 (32). 9711-9723.
Status: Published
Grosso, G., Sandholm, K., Antovic, A., Gunnarsson, I., Zickert, A., et al. (2021). The Complex Relationship between C4b-Binding Protein, Warfarin, and Antiphospholipid Antibodies. Thrombosis and Haemostasis. 121 (10). 1299-1309.
Status: Published
Sandholm, K., Carlsson, H., Persson, B., Skattum, L., Tjernberg, I., et al. (2020). Discrepancies in plasma levels of complement components measured by a newly introduced commercially available magnetic bead technique compared to presently available clinical reference intervals. Scandinavian Journal of Immunology. 91 (2). 1-3.
Status: Published
Carlsson, H., Sandholm, K., Haddish, H.W., Brudin, L., Nilsson Ekdahl, K., et al. (2020). Complement activation in individuals with previous subclinical Lyme borreliosis and patients with previous Lyme neuroborreliosis. European Journal of Clinical Microbiology and Infectious Diseases. 39 (5). 855-862.
Status: Published
Yoshihara, A., Watanabe, S., Goel, I., Ishihara, K., Nilsson Ekdahl, K., et al. (2020). Promotion of cell membrane fusion by cell-cell attachment through cell surface modification with functional peptide-PEG-lipids. Biomaterials. 253. 1-10.
Status: Published
Eriksson, O., Hultström, M., Persson, B., Lipcsey, M., Nilsson Ekdahl, K., et al. (2020). Mannose-Binding Lectin is Associated with Thrombosis and Coagulopathy in Critically Ill COVID-19 Patients. Thrombosis and Haemostasis. 120 (12). 1720-1724.
Status: Published
Fromell, K., Adler, A., Åman, A., Manivel, V.A., Huang, S., et al. (2020). Assessment of the Role of C3(H₂O) in the Alternative Pathway. Frontiers in Immunology. 11. 1-13.
Status: Published
Halbgebauer, R., Karasu, E., Braun, C.K., Palmer, A., Braumueller, S., et al. (2020). Thirty-Eight-Negative Kinase 1 Is a Mediator of Acute Kidney Injury in Experimental and Clinical Traumatic Hemorrhagic Shock. Frontiers in Immunology. 11. 1-12.
Status: Published
Vogt, L.M., Kwasniewicz, E., Talens, S., Scavenius, C., Bielecka, E., et al. (2020). Apolipoprotein E Triggers Complement Activation in Joint Synovial Fluid of Rheumatoid Arthritis Patients by Binding C1q. Journal of Immunology. 204 (10). 2779-2790.
Status: Published
Svenungsson, E., Gustafsson, J.T., Grosso, G., Rossides, M., Gunnarsson, I., et al. (2020). Complement deposition, C4d, on platelets is associated with vascular events in systemic lupus erythematosus. Rheumatology. 59 (11). 3264-3274.
Status: Published
Zeuthen, C.M., Shahrokhtash, A., Fromell, K., Nilsson Ekdahl, K., Mohammad-Beigi, H., et al. (2020). C1q recognizes antigen-bound IgG in a curvature-dependent manner. Nano Reseach. 13. 1651-1658.
Status: Published
Teramura, Y., Nilsson Ekdahl, K., Fromell, K., Nilsson, B., Ishihara, K. (2020). Potential of Cell Surface Engineering with Biocompatible Polymers for Biomedical Applications. Langmuir. 36 (41). 12088-12106.
Status: Published
Håkansson, I., Ernerudh, J., Vrethem, M., Dahle, C., Nilsson Ekdahl, K. (2020). Complement activation in cerebrospinal fluid in clinically isolated syndrome and early stages of relapsing remitting multiple sclerosis. Journal of Neuroimmunology. 340. 1-8.
Status: Published
Tjernberg, A.R., Woksepp, H., Sandholm, K., Johansson, M., Dahle, C., et al. (2020). Celiac disease and complement activation in response to Streptococcus pneumoniae. European Journal of Pediatrics. 179 (1). 133-140.
Status: Published
Kodama, T., Yoshihara, A., Goel, I., Sekino, M., Kuwahata, A., et al. (2020). Identification of Metal-Binding Peptides and Their Conjugation onto Nanoparticles of Superparamagnetic Iron Oxides and Liposomes. ACS Applied Materials and Interfaces. 12 (22). 24623-24634.
Status: Published
Azuma, T., Matsushita, T., Manivel, V.A., Nilsson Ekdahl, K., Nilsson, B., et al. (2020). Poly(2-aminoethyl methacrylate)-based polyampholyte brush surface with carboxylic groups to improve blood compatibility. Journal of Biomaterials Science. Polymer Edition. 31 (5). 679-693.
Status: Published
Messerer, D.A.C., Vidoni, L., Erber, M., Stratmann, A.E.P., Bauer, J.M., et al. (2020). Animal-Free Human Whole Blood Sepsis Model to Study Changes in Innate Immunity. Frontiers in Immunology. 11. 1-12.
Status: Published
Gustafson, E., Hamad, O.A., Deckmyn, H., Barbu, A., Nilsson Ekdahl, K., et al. (2019). Exposure of von Willebrand Factor on Isolated Hepatocytes Promotes Tethering of Platelets to the Cell Surface. Transplantation. 103 (8). 1630-1638.
Status: Published
Van Griensven, M., Ricklin, D., Denk, S., Halbgebauer, R., Braun, C.K., et al. (2019). Protective Effects of the Complement Inhibitor Compstatin CP40 in Hemorrhagic Shock. Shock. 51 (1). 78-87.
Status: Published
Noiri, M., Asawa, K., Okada, N., Kodama, T., Murayama, Y., et al. (2019). Modification of human MSC surface with oligopeptide-PEG-lipids for selective binding to activated endothelium. Journal of Biomedical Materials Research. Part A. 107 (8). 1779-1792.
Status: Published
Zhao, F., Afonso, S., Lindner, S., Hartmann, A., Loeschmann, I., et al. (2019). C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3-and C5-Convertases. Frontiers in Immunology. 10. 1-14.
Status: Published
Sandholm, K., Persson, B., Skattum, L., Eggertsen, G., Nyman, D., et al. (2019). Evaluation of a Novel Immunoassay for Quantification of C1q for Clinical Diagnostic Use. Frontiers in Immunology. 10.
Status: Published
Toda, S., Fattah, A., Asawa, K., Nakamura, N., Nilsson Ekdahl, K., et al. (2019). Optimization of Islet Microencapsulation with Thin Polymer Membranes for Long-Term Stability. Micromachines. 10 (11). 1-10.
Status: Published
Nilsson Ekdahl, K., Mohlin, C., Adler, A., Aman, A., Manivel, V.A., et al. (2019). Is generation of C-3(H₂O) necessary for activation of the alternative pathway in real life?. Molecular Immunology. 114. 353-361.
Status: Published
Asif, S., Asawa, K., Inoue, Y., Ishihara, K., Lindell, B., et al. (2019). Validation of an MPC Polymer Coating to Attenuate Surface-Induced Crosstalk between the Complement and Coagulation Systems in Whole Blood in In Vitro and In Vivo Models. Macromolecular Bioscience. 19 (5).
Status: Published
Knabl, L., Berktold, M., Hamad, O., Fromell, K., Chatterjee, S., et al. (2018). Shiga toxin 2a binds antithrombin and heparin, but does not directly activate platelets. International Journal of Medical Microbiology. 308 (7). 969-976.
Status: Published
Mohlin, C., Sandholm, K., Kvanta, A., Nilsson Ekdahl, K., Johansson, K. (2018). A model to study complement involvement in experimental retinal degeneration.. Upsala Journal of Medical Sciences. 123 (1). 28-42.
Status: Published
Labriere, C., Kondori, N., Caous, J.S., Boomgaren, M., Sandholm, K., et al. (2018). Development and evaluation of cationic amphiphilic antimicrobial 2,5-diketopiperazines. Journal of Peptide Science. 24 (7).
Status: Published
Nilsson Ekdahl, K., Davoodpour, P., Ekstrand-Hammarström, B., Fromell, K., Hamad, O.A., et al. (2018). Contact (kallikrein/kinin) system activation in whole human blood induced by low concentrations of α-Fe₂O₃ nanoparticles. Nanomedicine : Nanotechnology, Biology and Medicine. 14 (3). 735-744.
Status: Published
Teramura, Y., Asif, S., Nilsson Ekdahl, K., Gustafson, E., Nilsson, B. (2017). Cell Adhesion Induced Using Surface Modification with Cell-Penetrating Peptide-Conjugated Poly(ethylene glycol)-Lipid : A New Cell Glue for 3D Cell-Based Structures. ACS Applied Materials and Interfaces. 9 (1). 244-254.
Status: Published
Gustafson, E., Asif, S., Kozarcanin, H., Elgue, G., Meurling, S., et al. (2017). Control of IBMIR Induced by Fresh and Cryopreserved Hepatocytes by Low Molecular Weight Dextran Sulfate Versus Heparin. Cell Transplantation. 26 (1). 71-81.
Status: Published
Denk, S., Neher, M.D., Messerer, D.A.C., Wiegner, R., Nilsson, B., et al. (2017). Complement C5a Functions as a Master Switch for the pH Balance in Neutrophils Exerting Fundamental Immunometabolic Effects. Journal of Immunology. 198 (12). 4846-4854.
Status: Published
Harboe, M., Johnson, C., Nymo, S., Ekholt, K., Schjalm, C., et al. (2017). Properdin binding to complement activating surfaces depends on initial C3b deposition. Proceedings of the National Academy of Sciences of the United States of America. 114 (4). E534-E539.
Status: Published
Seisenbaeva, G.A., Fromell, K., Vinogradov, V.V., Terekhov, A.N., Pakhomov, A.V., et al. (2017). Dispersion of TiO₂ nanoparticles improves burn wound healing and tissue regeneration through specific interaction with blood serum proteins. Scientific Reports. 7.
Status: Published
Fromell, K., Yang, Y., Nilsson Ekdahl, K., Nilsson, B., Berglin, M., et al. (2017). Absence of conformational change in complement factor 3 and factor XII adsorbed to acrylate polymers is related to a high degree of polymer backbone flexibility. Biointerphases. 12 (2).
Status: Published
Duehrkop, C., Leneweit, G., Heyder, C., Fromell, K., Edwards, K., et al. (2016). Development and characterization of an innovative heparin coating to stabilize and protect liposomes against adverse immune reactions. Colloids and Surfaces B : Biointerfaces. 141. 576-583.
Status: Published
Kozarcanin, H., Lood, C., Munthe-Fog, L., Sandholm, K., Hamad, O.A., et al. (2016). The lectin complement pathway serine proteases (MASPs) represent a possible crossroad between the coagulation and complement systems in thromboinflammation. Journal of Thrombosis and Haemostasis. 14 (3). 531-545.
Status: Published
Teramura, Y., Nilsson Ekdahl, K., Barbu, A. (2016). A hybrid of cells and pancreatic islets toward a new bioartificial pancreas.. Regenerative Therapy. 3 (Special Issue). 68-74.
Status: Published
Nilsson Ekdahl, K., Huang, S., Nilsson, B., Teramura, Y. (2016). Complement inhibition in biomaterial- and biosurface-induced thromboinflammation. Seminars in Immunology. 28 (3). 268-277.
Status: Published
Harboe, M., Johnson, C., Nymo, S., Ekholt, K., Schjalm, C., et al. (2016). Molecular modelling showed optimal fit between TSR5 in trimeric properdin and C345C in the C3b moiety for stabilization of the alternative convertase, whereas binding to molecular patterns in myeloperoxidase, endothelial cells and Neisseria meningitides was indirectly mediated by initial C3 activation. Immunobiology. 221 (10). 1205-1205.
Status: Published
Huang, S., Engberg, A.E., Jonsson, N., Sandholm, K., Nicholls, I.A., et al. (2016). Reciprocal relationship between contact and complement system activation on artificial polymers exposed to whole human blood.. Biomaterials. 77. 111-119.
Status: Published
Lindblom, R.P.F., Aeinehband, S., Ström, M., Al Nimer, F., Sandholm, K., et al. (2016). Complement receptor 2 is increased in cerebrospinal fluid of multiple sclerosis patients and regulates C3 function. Clinical Immunology. 166. 89-95.
Status: Published
Asif, S., Nilsson Ekdahl, K., Fromell, K., Gustafson, E., Barbu, A., et al. (2016). Heparinization of cell surfaces with short peptide-conjugated PEG-lipid regulates thromboinflammation in transplantation of human MSCs and hepatocytes. Acta Biomaterialia. 35. 194-205.
Status: Published
Christensen, K., Kozarcanin, H., Nilsson Ekdahl, K., Nilsson, B. (2016). Evidence of contact activation in patients suffering from ST-elevation myocardial infarction. Thrombosis Research. 141. 158-162.
Status: Published
Ekstrand-Hammarström, B., Hong, J., Davoodpour, P., Sandholm, K., Nilsson Ekdahl, K., et al. (2015). TiO₂ nanoparticles tested in a novel screening whole human blood model of toxicity trigger adverse activation of the kallikrein system at low concentrations. Biomaterials. 51. 58-68.
Status: Published
Hamad, O.A., Mitroulis, I., Fromell, K., Kozarcanin, H., Chavakis, T., et al. (2015). Contact activation of C3 enables tethering between activated platelets and polymorphonuclear leukocytes via CD11b/CD18. Thrombosis and Haemostasis. 114 (6). 1207-1217.
Status: Published
Klapper, Y., Maffre, P., Shang, L., Nilsson Ekdahl, K., Nilsson, B., et al. (2015). Low affinity binding of plasma proteins to lipid-coated quantum dots as observed by in situ fluorescence correlation spectroscopy. Nanoscale. 7 (22). 9980-9984.
Status: Published
Sfyroera, G., Ricklin, D., Reis, E., Chen, H., Wu, E., et al. (2015). Rare loss-of-function mutation in complement component C3 provides insight into molecular and pathophysiological determinants of complement activity. Journal of Immunology. 194 (7). 3305-3316.
Status: Published
Teramura, Y., Asif, S., Nilsson Ekdahl, K., Nilsson, B. (2015). Cell surface engineering for regulation of immune reactions in cell therapy. Advances in Experimental Medicine and Biology. 865. 189-209.
Status: Published
Engberg, A.E., Nilsson, P.H., Huang, S., Fromell, K., Hamad, O.A., et al. (2015). Prediction of inflammatory responses induced by biomaterials in contact with human blood using protein fingerprint from plasma. Biomaterials. 36. 55-65.
Status: Published
Rosengren-Holmberg, J.P., Andersson, J., Smith, J.R., Alexander, C., Alexander, M.R., et al. (2015). Heparin molecularly imprinted surfaces for the attenuation of complement activation in blood. Biomaterials Science. 3 (8). 1208-1217.
Status: Published
Aeinehband, S., Lindblom, R.P.F., Al Nimer, F., Vijayaraghavan, S., Sandholm, K., et al. (2015). Complement Component C3 and Butyrylcholinesterase Activity Are Associated with Neurodegeneration and Clinical Disability in Multiple Sclerosis. PLOS ONE. 10 (4).
Status: Published
Huang, S., Sandholm, K., Jonsson, N., Nilsson, A., Wieslander, A., et al. (2015). Low concentrations of citrate reduce complement and granulocyte activation in vitro in human blood. Clinical Kidney Journal. 8 (1). 31-37.
Status: Published
Nilsson Ekdahl, K., Teramura, Y., Asif, S., Jonsson, N., Magnusson, P., et al. (2015). Thromboinflammation in therapeutic medicine. Advances in Experimental Medicine and Biology. 865. 3-17.
Status: Published
Lindblom, R.P.F., Berg, A., Ström, M., Aeinehband, S., Dominguez, C.A., et al. (2015). Complement receptor 2 is up regulated in the spinal cord following nerve root injury and modulates the spinal cord response. Journal of Neuroinflammation. 12.
Status: Published
Kumar, J., Lind, P.M., Salihovic, S., Van Bavel, B., Nilsson Ekdahl, K., et al. (2014). Influence of persistent organic pollutants on the complement system in a population-based human sample. Environment International. 71. 94-100.
Status: Published
Klapper, Y., Hamad, O.A., Teramura, Y., Leneweit, G., Nienhaus, G.U., et al. (2014). Mediation of a non-proteolytic activation of complement component C3 by phospholipid vesicles. Biomaterials. 35 (11). 3688-3696.
Status: Published
Nilsson, B., Hamad, O., Ahlström, H., Kullberg, J., Johansson, L., et al. (2014). C3 and C4 are strongly related to adipose tissue variables and cardiovascular risk factors. European Journal of Clinical Investigation. 44 (6). 587-596.
Status: Published
Moll, G., Alm, J.J., Davies, L.C., Von Bahr, L., Heldring, N., et al. (2014). Do Cryopreserved Mesenchymal Stromal Cells Display Impaired Immunomodulatory and Therapeutic Properties?. Stem Cells. 32 (9). 2430-2442.
Status: Published
Sandholm, K., Henningsson, A.J., Säve, S., Bergström, S., Forsberg, P., et al. (2014). Early Cytokine Release in Response to Live Borrelia burgdorferi Sensu Lato Spirochetes Is Largely Complement Independent. PLOS ONE. 9 (9). e108013.
Status: Published
Forsberg, U., Jonsson, P., Stegmayr, C., Jonsson, F., Nilsson, B., et al. (2013). A high blood level in the venous chamber and a wet-stored dialyzer help to reduce exposure for microemboli during hemodialysis. Hemodialysis International. 17 (4). 612-617.
Status: Published
Darreh-Shori, T., Vijayaraghavan, S., Aeinehband, S., Piehl, F., Lindblom, R.P.F., et al. (2013). Functional variability in butyrylcholinesterase activity regulates intrathecal cytokine and astroglial biomarker profiles in patients with Alzheimer's disease. Neurobiology of Aging. 34 (11). 2465-2481.
Status: Published
Nilsson, P.H., Nilsson Ekdahl, K., Magnusson, P.U., Qu, H., Iwata, H., et al. (2013). Autoregulation of thromboinflammation on biomaterial surfaces by a multicomponent therapeutic coating. Biomaterials. 34 (4). 985-994.
Status: Published
Bäck, J., Lood, C., Bengtsson, A.A., Nilsson Ekdahl, K., Nilsson, B. (2013). Contact activation products are new potential biomarkers to evaluate the risk of thrombotic events in systemic lupus erythematosus. Arthritis Research & Therapy . 15 (6).
Status: Published
Vijayaraghavan, S., Karami, A., Aeinehband, S., Behbahani, H., Grandien, A., et al. (2013). Regulated Extracellular Choline Acetyltransferase Activity : The Plausible Missing Link of the Distant Action of Acetylcholine in the Cholinergic Anti-Inflammatory Pathway. PLOS ONE. 8 (6).
Status: Published
Bergman, I., Sandholm, K., Nilsson Ekdahl, K., Okumura, N., Uenishi, H., et al. (2013). MBL1 genotypes in wild boar populations from Sweden, Austria, the Czech Republic and Japan. International Journal of Immunogenetics. 40 (2). 131-139.
Status: Published
Boij, R., Svensson, J., Nilsson Ekdahl, K., Sandholm, K., Lindahl, T., et al. (2012). Biomarkers of coagulation, inflammation and angiogenesis are independently associated with preeclampsia. American Journal of Reproductive Immunology and Microbiology. 68 (3). 258-270.
Status: Published
Moll, G., Rasmusson-Duprez, I., Von Bahr, L., Conolly-Andersen, A., Elgue, G., et al. (2012). Are therapeutic human mesenchymal stromal cells compatible with human blood?. Stem Cells. 30 (7). 1565-1574.
Status: Published
Bergman, I., Edman, K., Nilsson Ekdahl, K., Rosengren, K.J., Edfors, I. (2012). Extensive polymorphism in the porcine Toll-like receptor 10 gene. International Journal of Immunogenetics. 39 (1). 68-76.
Status: Published
Nilsson Ekdahl, K., Engberg, A.E., Rosengren-Holmberg, J.P., Chen, H., Lambris, J., et al. (2011). Blood protein-polymer adsorption fingerprinting: Implications for understanding hemoocompatibility and for biomaterial design.. Journal of Biomedical Materials Research. Part A. 97A (1). 74-84.
Status: Published
Wu, Y., Qu, H., Sfyroera, G., Tzekou, A., Kay, B., et al. (2011). Protection of Nonself Surfaces from Complement Attack by Factor H-Binding Peptides : Implications for Therapeutic Medicine. Journal of Immunology. 186 (7). 4269-4277.
Status: Published
Moll, G., Jitschin, R., Von Bahr, L., Rasmusson-Duprez, I., Sundberg, B., et al. (2011). Mesenchymal Stromal Cells Engage Complement and Complement Receptor Bearing Innate Effector Cells to Modulate Immune Responses (Open Access). PLOS ONE. 6 (7). e21703.
Status: Published
Bäck, J., Sanchez, J., Elgue, G., Nilsson Ekdahl, K., Nilsson, B. (2010). Activated human platelets induce factor XIIa-mediated contact activation. Biochemical and Biophysical Research Communications - BBRC. 391 (1). 11-17.
Status: Published
Nilsson, P.H., Engberg, A.E., Bäck, J., Faxälv, L., Lindahl, T., et al. (2010). The creation of an antithrombotic surface by apyrase immobilization. Biomaterials. 31 (16). 4484-4491.
Status: Published
Nilsson, B., Korsgren, O., Lambris, J., Nilsson Ekdahl, K. (2010). Can cells and biomaterials in therapeutic medicine be shielded from innate immune recognition. Trends in immunology. 31 (1). 32-38.
Status: Published
Hamad, O., Nilsson, P.H., Wouters, D., Lambris, J., Nilsson Ekdahl, K., et al. (2010). Complement Component C3 Binds to Activated Normal Platelets without Preceding Proteolytic Activation and Promotes Binding to Complement Receptor 1. Journal of Immunology. 184 (5). 2686-2692.
Status: Published
Lundgren, B.A., Rorsman, F., Portela-Gomes, G., Grimelius, L., Nilsson Ekdahl, K., et al. (2010). Identification of complement C3 as an autoantigen in inflammatory bowel disease. Journal of Gastroenterology and Hepatology. 2 (4). 429-436.
Status: Published
Hamad, O.A., Nilsson, P.H., Lasaosa, M., Ricklin, D., Lambris, J.D., et al. (2010). Contribution of Chondroitin Sulfate A to the Binding of Complement Proteins to Activated Platelets. PLOS ONE. 5 (9).
Status: Published
Babiker, A.A., Magnusson, P.U., Ronquist, G., Nilsson, B., Nilsson Ekdahl, K. (2010). Mapping Pro- and Antiangiogenic Factors on the Surface of Prostasomes of Normal and Malignant Cell Origin. The Prostate. 70 (8). 834-847.
Status: Published
Tsai, J.A., Lund, M., Lundell, L., Nilsson Ekdahl, K. (2009). One-lung ventilation during thoracoabdominal esophagectomy elicits complement activation. Journal of Surgical Research. 152 (2). 331-337.
Status: Published
Nilsson Ekdahl, K., Blomberg, C., Henningsson Johnsson, A., Dahle, C., Håkansson, I., et al. (2009). Systemic and Intrathecal Complement Activation in Multiple Sclerosis and Guillan-Barré Syndrome. Molecular Immunology. 46 (14). 2848-2848.
Status: Published
Bexborn, F., Engberg, A.E., Sandholm, K., Mollnes, T.E., Hong, J., et al. (2009). Hirudin versus heparin for use in whole blood in vitro biocompatibility models. Journal of Biomedical Materials Research. Part A. 89A (4). 951-959.
Status: Published
Engberg, A.E., Sandholm, K., Bexborn, F., Persson, J., Nilsson, B., et al. (2009). Inhibition of complement activation on a model biomaterial surface by streptococcal M protein-derived peptides. Biomaterials. 30 (13). 2653-2659.
Status: Published
Hamad, O., Nilsson, P.H., Lambris, J.D., Nilsson Ekdahl, K., Nilsson, B. (2009). Binding of complement proteins to activated platelets is independent of complement activation. Molecular Immunology. 46 (14). 2853-2853.
Status: Published
Mangsbo, S., Sanchez, J., Anger, K., Lambris, J., Nilsson Ekdahl, K., et al. (2009). Complement activation by CpG in a human whole blood loop system: mechanisms and immunomodulatory effects. Journal of Immunology. 183 (10). 6724-6732.
Status: Published
Bäck, J., Huber-Lang, M., Elgue, G., Kalbitz, M., Sanchez, J., et al. (2009). Distinctive regulation of contact activation by antithrombin and C1-inhibitor on activated platelets and material surfaces. Biomaterials. 30 (34). 6573-6580.
Status: Published
Bexborn, F., Andersson, P.O., Chen, H., Nilsson, B., Nilsson Ekdahl, K. (2008). The Tick-Over Theory Revisited: Formation and Regulation of the Soluble Alternative Complement C3 Convertase (C3(H2O)Bb). Molecular Immunology. 45 (8). 2370-2379.
Status: Published
Goto, M., Tjernberg, J., Dufrane, D., Elgue, G., Brandhorst, D., et al. (2008). Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation. Xenotransplantation. 15 (4). 225-234.
Status: Published
Tjernberg, J., Nilsson Ekdahl, K., Lambris, J., Korsgren, O., Nilsson, B. (2008). Acute antibody-mediated complement activation mediates lysis of pancreatic islets cells and may cause tissue loss in clinical islet transplantation. Transplantation. 85 (8). 1193-1199.
Status: Published
Hamad, O.A., Nilsson Ekdahl, K., Nilsson, P.H., Andersson, J., Magotti, P., et al. (2008). Complement activation triggered by chondroitin sulfate reelased by thrombin receptor-activated platelets. Journal of Thrombosis and Haemostasis. 6 (8). 1413-1421.
Status: Published
Henningsson, A.J., Ernerudh, J., Sandholm, K., Carlsson, S., Granlund, H., et al. (2007). Raised Intrathecal Levels of Complement Components C1q and C3a in Acute Neuroborreliosis. Journal of Neuroimmunology. 183 (1-2). 200-207.
Status: Published
Norda, R., Knutson, F., Berseus, O., Åkerblom, O., Nilsson Ekdahl, K., et al. (2007). Unexpected effects of donor gender on the storage of liquid plasma. Vox Sanguinis. 93 (3). 223-228.
Status: Published
Markiewski, M., Nilsson, B., Nilsson Ekdahl, K., Mollnes, T.E., Lambris, J.D. (2007). Complement and Coagulation: Strangers or Partners in Crime?. Trends in Immunology. 28 (4). 184-192.
Status: Published
Nilsson Ekdahl, K., Norberg, D., Sturfelt, G., Nilsson, U.R., Nilsson, B. (2007). A rapid, inexpensive, and easy-to-perform haemolytic complement assay using serum of buffer-changed EDTA-plasma: Its use for differential diagnosis and follow-up of patients with systemic lupus erythematosus. Clinical and Vaccine Immunology. 14 (5). 549-555.
Status: Published
Babiker, A.A., Nilsson Ekdahl, K., Nilsson, B., Ronquist, G. (2007). Prothrombotic Effects of Prostasomes Isolated from Prostatic Cell Lines and Seminal Plasma. Seminars in Thrombosis and Hemostasis. 33. 80-86.
Status: Published
Nilsson Ekdahl, K., Henningsson, A.J., Sandholm, K., Forsberg, P., Ernerudh, J., et al. (2007). Immunity in borreliosis with special emphasis on the role of complement. Advances in Experimental Medicine and Biology. 598. 198-213.
Status: Published
Babiker, A.A., Hamad, O.A., Sanchez, J., Ronquist, G., Nilsson, B., et al. (2007). Prothrombotic Effect of Prostasomes of Metastatic Cell and Seminal Origin. The Prostate. 67. 378-388.
Status: Published
Andersson, J., Bexborn, F., Klinth, J., Nilsson, B., Nilsson Ekdahl, K. (2006). Functionalized Pluronic˙ as a linker for immobilization of bioactive molecules on a material surface - a new strategy towards improved biomaterial-blood compatibility. Journal of biomedical materials research. 76A (1). 25-34.
Status: Published
Klinth, J., Larsson, R., Andersson, P.O., Nilsson Ekdahl, K. (2006). A novel application of multi-wavelength TIRF spectroscopy for real time monitoring of antithrombin interactions with immobilized heparin. Biosensors & bioelectronics. 21 (10). 1973-1980.
Status: Published
Nilsson, B., Nilsson Ekdahl, K., Mollnes, T.E., Lambris, J.D. (2006). The role of complement in biomaterial-induced inflammation. Molecular immunology. 44 (1-3). 82-94.
Status: Published
Babiker, A.A., Ronquist, G., Nilsson, B., Nilsson Ekdahl, K. (2006). Overexpression of ecto-protein kinases in prostasomes of metastatic origin. Prostate. 66 (7). 675-686.
Status: Published
Mathsson, L., Tejde, A., Carlson, K., Höglund, M., Nilsson, B., et al. (2005). Cryoglobulin-induced cytokine production via Fc-gamma-RIIa: inverse effects of complement blockade on the production of TNF-alfa and IL-10. Implications for the growth of malignant B-cell clones. British journal of haematology. 129 (6). 830-838.
Status: Published
Johansson, H., Lukinius, A., Moberg, L., Lundgren, T., Berne, C., et al. (2005). Tissue factor produced by the endocrine cells of the islets of Langerhans is associated with a negative outcome of clinical islet transplantation. Diabetes. 54 (6). 1755-1762.
Status: Published
Babiker, A.A., Nilsson, B., Ronquist, G., Carlsson, L., Nilsson Ekdahl, K. (2005). Transfer of functional prostasomal CD59 of metastatic prostatic cancer cell origin protects cells against complement attack. The prostate. 62 (2). 105-114.
Status: Published
Hong, J., Azens, A., Nilsson Ekdahl, K., Granqvist, C.G., Nilsson, B. (2005). Contact between various metal surfaces and whole blood causes material-specific thrombin generation. Biomaterials. 26 (12). 1397-1403.
Status: Published
Andersson, J., Nilsson Ekdahl, K., Lambris, J.D., Nilsson, B. (2005). Complement activation on a model biomaterial surface: Binding of C3b via the alternative amplification loop to plasma proteins adsorbed to the surface. Biomaterials. 26 (13). 1477-1485.
Status: Published
Janssen, B.J.C., Huizinga, E.G., Raaijmakers, H.C.A., Roos, A., Daha, M.R., et al. (2005). Structures of complement component C3 provide insights into the function and evolution of immunity. Nature. 437 (7058). 505-511.
Status: Published
Nilsson Ekdahl, K., Bengtsson, A.A., Andersson, J., Elgue, G., Rönnblom, L., et al. (2004). Thrombotic disease in systemic lupus erythematosus is associated with a maintained systemic platelet activation. British journal of haematology. 125 (1). 74-78.
Status: Published
Tejde, A., Mathsson, L., Nilsson Ekdahl, K., Nilsson, B., Rönnelid, J. (2004). Immune complex stimulation of peripheral blood mononuclear cells result in enhancement or suppression of IL-12 production dependent on access to a functionally active complement system. Clinical and experimental immunology. 137 (3). 521-528.
Status: Published
Rönnelid, J., Tejde, A., Mathsson, L., Nilsson Ekdahl, K., Nilsson, B. (2003). Immune complexes from SLE sera induce IL-10 production by a Fc-RII-dependent mechanism: A possible vicious circle maintaining B cell hyperactivity in SLE. Annals of the Rheumatic Diseases. 62. 37-42.
Status: Published
Andersson, J., Sanchez, J., Nilsson Ekdahl, K., Elgue, G., Nilsson, B., et al. (2003). Optimal heparin surface concentration and antithrombin binding capacity as evaluated with human non-anticoagulated blood in vitro. Journal of biomedical materials research. 67A (2). 458-466.
Status: Published
Moberg, L., Johansson, H., Luknius, A., Berne, C., Foss, A., et al. (2002). Expression and secretion of tissue factor in the islets of Langerhans: A likely explanation for the development of thrombotic reactions in clinical islet transplantation (IBMIR) in vitro. Lancet. 360. 2039-2045.
Status: Published
Andersson, J., Nilsson Ekdahl, K., Larsson, R., Nilsson, U.R., Nilsson, B. (2002). C3 adsorbed to a polymer surface can form an initiating alternative pathway convertase. Journal of immunology. 168. 5786-5791.
Status: Published
Özmen, L., Nilsson Ekdahl, K., Elgue, G., Larsson, R., Korsgren, O., et al. (2002). Inhibition of Thrombin Abrogates the Instant Blood-Mediated Inflammatory Reaction Triggered by Isolated Human Islets : Possible application of the thrombin inhibitor melagatran in clinical islet transplantation. Diabetes. 51 (6). 1779-1784.
Status: Published
Nilsson Ekdahl, K., Nilsson, B. (2001). Increased affinity between CR1 and C3b phosphorylated by a casein kinase released by activated human platelets. European journal of immunology. 31. 1047-1054.
Status: Published
Gröndahl, G., Johannisson, A., Jensen-Waern, M., Nilsson Ekdahl, K. (2001). Opsonization of yeast cells with equine C3 and IgG. Veterinary immunology and immunopathology. 6425. 1-15.
Status: Published
Andersson, J., Larsson, R., Richter, R., Nilsson Ekdahl, K., Nilsson, B. (2001). Binding of a model regulator of complement activation (RCA) to a biomaterial surface: Surface-bound factor H inhibits complement activation. Biomaterials. 22 (17). 2435-2443.
Status: Published
Hong, J., Larsson, A., Nilsson Ekdahl, K., Elgue, G., Larsson, R., et al. (2001). Contact between a polymer and whole blood: the sequence of events leading to thrombin generation. The journal of laboratory and clinical medicine. 138. 139-145.
Status: Published
Jokiranta, T.S., Westin, J., Nilsson, B., Nilsson Ekdahl, K., Hellwage, J., et al. (2001). Complement C3b interactions with its ligands measured by Biacore equipment: a new powerful and informative method. International immunopharmacology. 1. 495-506.
Status: Published
Wennberg, L., Sundberg, B., Nilsson Ekdahl, K., Korsgren, O. (2001). C-peptide determinations in islet xenotransplantation: A study in the pig-to-mouse model. Cell transplantation. 10. 165-173.
Status: Published
Nilsson Ekdahl, K., Nilsson, B. (1999). Profound alterations in C3 functions caused by phosphorylation by a casein kinase released by activated human platelets with special reference to thiol ester function. Journal of immunology. 162. 7426-7433.
Status: Published
Hong, J., Andersson, J., Nilsson Ekdahl, K., Elgue, G., Axén, N., et al. (1999). Titanium is a highly thrombogenic biomaterial: Possible implications for osteogenesis. Thrombosis and haemostasis. 82. 58-64.
Status: Published
Nilsson Ekdahl, K., Nilsson, B. (1999). Phosphorylation of plasma proteins with emphasis on complement component C3. Molecular immunology. 36 (4-5). 233-240.
Status: Published
Nilsson Ekdahl, K., Elgue, G., Nilsson, B. (1999). Phosphorylation of coagulation factor XI by a casein kinase released by activated human platelets increases its susceptibility to activation by factor XIIa and thrombin. Thrombosis and haemostasis. 82. 1283-1289.
Status: Published
Hong, J., Nilsson Ekdahl, K., Reynolds, H., Larsson, R., Nilsson, B. (1999). A new in vitro model to study interaction between whole blood and biomaterials. Studies of platelet and coagulation activation and the effect of aspirin. Biomaterials. 20. 603-611.
Status: Published
Nilsson, B., Hong, J., Larsson, R., Elgue, G., Nilsson Ekdahl, K., et al. (1998). Compstatin inhibits complement and cellular activation in whole blood in models for extracorpereal circulation. Blood. 92. 1661-1667.
Status: Published
Rönnelid, J., Gunnarsson, I., Nilsson Ekdahl, K., Nilsson, B. (1997). Correlation between anti-C1q and immune conglutinin levels, but not between levels of antibodies to the stucturally related autoantigens C1q and type II collagen in SLE or RA. Journal of autoimmunity. 10. 415-423.
Status: Published
Nilsson Ekdahl, K., Rönnblom, L., Sturfeldt, G., Nilsson, B. (1997). Increased phosphate content in complement component C3, fibrinogen, vitronectin and other plasma proteins in SLE. Covariations with platelet activation and possible association with thrombosis. Arthritis and rheumatism. 40. 2178-2186.
Status: Published
Larsson, R., Elgue, G., Larsson, A., Nilsson Ekdahl, K., Nilsson, U.R., et al. (1997). Inhibition of complement activation by soluble recombinant CR1 under conditions resembling those in a cardiopulmonary circuit: Reduced up-regulation of CD11b and complete abrogation of binding of PMNs to the biomaterial. Immunopharmacology. 38. 119-127.
Status: Published
Nilsson Ekdahl, K., Lööf, L., Ahrenstedt, Ö., Nilsson, U.R., Nilsson, B. (1997). Defective elimination of C3b/iC3b-coated autologous erythrocytes in patients with primary biliary cirrhosis, alcoholic cirrhosis, and ulcerative colitis. The journal of laboratory and clinical medicine. 130. 285-292.
Status: Published
Nilsson Ekdahl, K., Nilsson, B. (1997). Phosphorylation of complement component C3 after synthesis in U937 cells by a putative protein kinase CK2, which is regulated by CD11b: Evidence that membrane-bound proteases preferentially cleave phosphorylated C3. Biochemical journal. 328. 625-633.
Status: Published
Gong, J., Larsson, R., Nilsson Ekdahl, K., Mollnes, T.E., Nilsson, U.R., et al. (1996). Chandler loops as a model for cardiopulmonary bypass circuits: Both the biomaterial and the blood- gas interaces induce complement activation in an in vitro model. Journal of clinical immunology. 16. 223-230.
Status: Published
Nilsson Ekdahl, K., Nilsson, B. (1995). Phosphorylation of complement component C3 and C3 fragments by a human platelet protein kinase. Inhibition of factor I mediated cleavage of C3b. Journal of immunology. 154. 6502-6509.
Status: Published
Nilsson Ekdahl, K., Michaëlsson, G., Gerdén, B., Lööf, L., Nilsson, B. (1995). Impairments in complement receptor- and Fc receptor-mediated functions in psoriasis. Archives of dermatological research. 287. 225-230.
Status: Published
Toomik, R., Nilsson Ekdahl, K., Ekman, P. (1994). Demonstration of the regulation of phosphorylase by reversible phosphorylation and allosteric effectors. Biochemical Education. 22 (4). 205-207.
Status: Published
Pekna, M., Nilsson, L., Nilsson Ekdahl, K., Nilsson, U.R., Nilsson, B. (1993). Evidence for iC3 generation during cardiopulmonary bypass as the result of blood-gas interaction. Clinical and experimental immunology. 91. 404-409.
Status: Published
Nilsson, U.R., Larm, O., Storm, K.E., Nilsson, B., Elwing, H., et al. (1993). Modification of the complement binding properties of polystyrene: Effects of end-point heparin attachment. Scandinavian journal of immunology. 37. 349-354.
Status: Published
Nilsson Ekdahl, K., Nilsson, B., Gölander, C.G., Elwing, H., Lassen, B., et al. (1993). Complement activation on radio frequency plasma modified polystyrene surfaces. Journal of colloid and interface science. 158. 121-128.
Status: Published
Gölander, C.G., Lassen, B., Nilsson Ekdahl, K., Nilsson, U.R. (1993). RF-plasma-modified polystyrene surfaces for studying complement activation. Journal of biomaterials science. Polymer edition. 4. 25-30.
Status: Published
Nilsson Ekdahl, K., Pekna, M., Nilsson, B., Nilsson, U.R. (1992). Generation of iC3 on the interphase between blood and gas. Scandinavian Journal of Immunology. 35 (1). 85-91.
Status: Published
Nilsson Ekdahl, K. (1992). Further studies on the phosphorylation of rat liver fructose-1,6-bisphosphatase. Importance of the three-dimensional structure of a substrate to protein kinase A. Journal of biochemistry. 112. 719-723.
Status: Published
Nilsson, B., Grossberger, D., Nilsson Ekdahl, K., Riegert, P., Becherer, J.D., et al. (1992). Conformational differences between surface-bound and fluid-phase C3. Epitope mapping by cDNA expression. Biochemical journal. 282. 715-721.
Status: Published
Alston-Smith, J., Ware, J., Ljungqvist, O., Nilsson Ekdahl, K. (1992). The effects of hormones and calcium ionophore A23187 on the activity of pyruvate kinase in primary culture and freshly isolated rat hepatocytes. Life science advances. 11. 91-99.
Status: Published
Nilsson Ekdahl, K., Nilsson, B., Storm, K.E., Nilsson, U.R. (1992). Techniques to study functional properties of IgG preparations for parenteral use. Life science advances. 11. 221-227.
Status: Published
Nilsson, B., Nilsson Ekdahl, K., Sjöholm, A., Nilsson, U.R., Sturfelt, G. (1992). Detection and characterization of immunoconglutinins in patients with systemic lupus erythematosus (SLE): serial analysis in relation to disease course. Clinical and experimental immunology. 90. 251-255.
Status: Published
Nilsson Ekdahl, K., Lööf, L., Nyberg, A., Nilsson, U.R., Nilsson, B. (1991). Defective Fc receptor-mediated clearance in patients with primary biliary cirrhosis. Gastroenterology. 101 (4). 1076-1082.
Status: Published
Nilsson Ekdahl, K., Lööf, L., Nilsson, U.R., Nilsson, B. (1991). An improved method to study complement receptor-mediated function of the fixed macrophage system in vivo. Vox Sanguinis. 61 (1). 47-52.
Status: Published
Lavö, B., Nilsson, B., Lööf, L., Nilsson, U.R., Nilsson Ekdahl, K. (1991). Fc receptor function and circulating immune complexes in gluten sensitive enteropathy - possible significance of serum IgA. Gut. 32. 876-880.
Status: Published
Alston-Smith, J., Ljungqvist, O., Ware, J., Nilsson Ekdahl, K. (1991). Regulation of rat hepatocyte fructose 1,6-diphosphatase activity during endotoxemia. Surgical research communications. 11. 67-75.
Status: Published
Ahrenstedt, Ö., Knutson, L., Nilsson, B., Nilsson Ekdahl, K., Odlind, B., et al. (1990). Enhanced local production of the complement components in the small intestine in Crohn's disease. New England Journal of Medicine. 322. 1345-1349.
Status: Published
Nilsson Ekdahl, K., Nilsson, U.R., Nilsson, B. (1990). Inhibition of factor I by diisopropylfluorophosphate. Evidence of conformational changes in factor I induced by C3b and additional studies on the specificity of factor I. Journal of Immunology. 144 (11). 4269-4274.
Status: Published
Nilsson, B., Nilsson Ekdahl, K., Svarvare, M., Bjelle, A., Nilsson, U.R. (1990). Purification and characterization of IgG immunoconglutinins from patients with systemic lupus erythematosus: Implications for a regulatory function. Clinical and Experimental Immunology. 82 (2). 262-267.
Status: Published
Alston-Smith, J., Boija, P.O., Ware, J., Nilsson Ekdahl, K. (1990). Endotoxin, epinephrine, glucagon, insulin and calcium ionophore A23187 modulation of pyruvate kinase activity in cultured rat hepatocytes. Acta chirurgica Scandinavica. 156 (10). 677-681.
Status: Published
Nilsson, B., Nilsson Ekdahl, K., Avila, D., Nilsson, U.R., Lambris, J.D. (1990). Neoantigens in complement component C3 as detected by monoclonal antibodies. Mapping of the recognized epitopes by synthetic peptides. Biochemical Journal. 268 (1). 55-61.
Status: Published
Kuraya, M., Nilsson, B., Nilsson Ekdahl, K., Klein, E. (1990). C3d-mediated negative and positive signals on the proliferation of human B cells separated from blood. Immunology Letters. 26 (1). 51-58.
Status: Published
Nilsson, B., Nilsson Ekdahl, K., Svensson, K.E., Bjelle, A., Nilsson, U.R. (1989). Distinctive expression of neoantigenic C3(D) epitopes on bound C3 following activation and binding to different target surfaces in normal and pathological human sera. Molecular Immunology. 26 (4). 383-390.
Status: Published
Ramos, O.F., Nilsson, B., Nilsson Ekdahl, K., Eggertsen, G., Yefenov, E., et al. (1989). Elevated NK-mediated lysis of Raji and Daudi cells carrying fixed iC3b fragments. Cellular Immunology. 119 (2). 459-469.
Status: Published
Nilsson Ekdahl, K., Lööf, L., Nilsson, U.R., Nilsson, B. (1989). Development of an immunoassay for the detection of minute amounts of IgG-coated erythrocytes in whole blood: Its application for the assessment of Fc-mediated clearance of anti-D-coated erythrocytes in vivo. Vox Sanguinis. 57 (3). 188-192.
Status: Published
Nilsson Ekdahl, K. (1988). In vitro phosphorylation of fructose-1,6-bisphosphatase from rabbit and pig liver with cyclic AMP-dependent protein kinase. Archives of Biochemistry and Biophysics. 262 (1). 27-31.
Status: Published
Nilsson Ekdahl, K. (1987). Rat liver fructose-1,6-bisphosphatase: Identification of serine- 338 as a third major phosphorylation site for cyclic AMP-dependent protein kinase. Activity changes associated with multisite phosphorylation in vitro. Journal of Biological Chemistry. 262. 16699-16703.
Status: Published
Boija, P.O., Nilsson Ekdahl, K., Nylander, G., Ware, J. (1987). Hemorrhagic hypotension and hepatic cell pyruvate kinase and fructose-1,6-diphosphatase activity in vivo. Surgical research communications. 2. 119-124.
Status: Published
Nilsson Ekdahl, K. (1987). Studies on the regulation of rat liver pyruvate kinase and fructose-1,6-bisphosphatase. Upsala journal of medical sciences. 92 (3). 217-232.
Status: Published
Nilsson Ekdahl, K., Ekman, P. (1987). Effects of epinephrine, glucagon and insulin on the activity and degree of phosphorylation of fructose-1,6-bisphosphatase in cultured hepatocytes. Biochimica et Biophysica Acta. Molecular Cell Research. 929. 318-326.
Status: Published
Nilsson Ekdahl, K., Ekman, P. (1985). Fructose-1,6-bisphosphatase from rat liver. A comparison of the kinetics of the unphosphorylated enzyme and the enzyme phosphorylated by cyclic AMP-dependent protein kinase.. Journal of Biological Chemistry. 260. 14173-14179.
Status: Published
Nilsson Ekdahl, K., Ekman, P. (1984). Hepatic L-type pyruvate kinase: Separation of unphosphorylated, phosphorylated and proteolytically modified in vivo forms. Journal of Biochemistry (Tokyo). 95 (4). 917-924.
Status: Published
Nilsson Ekdahl, K., Ekman, P. (1984). The effect of fructose-2,6-bisphosphate and AMP on the activity of phosphorylated and unphosphorylated fructose-1,6 bisphosphatase from rat liver. FEBS letters. 167 (2). 203-209.
Status: Published

Article, review/survey (Refereed)

Mannes, M., Mastellos, D.C., Nilsson Ekdahl, K., Nilsson, B., Yancopoulou, D., et al. (2022). Complement C3 activation in the ICU : Disease and therapy as Bonnie and Clyde. Seminars in Immunology. Elsevier. 60.
Status: Published
Nilsson, B., Persson, B., Eriksson, O., Fromell, K., Hultström, M., et al. (2022). How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment. Frontiers in Immunology. Frontiers Media S.A.. 13.
Status: Published
Nilsson Ekdahl, K., Fromell, K., Mohlin, C., Teramura, Y., Nilsson, B. (2019). A human whole-blood model to study the activation of innate immunity system triggered by nanoparticles as a demonstrator for toxicity. Science and Technology of Advanced Materials. Taylor & Francis Group. 20 (1). 688-698.
Status: Published
Mohebnasab, M., Eriksson, O., Persson, B., Sandholm, K., Mohlin, C., et al. (2019). Current and Future Approaches for Monitoring Responses to Anti-complement Therapeutics. Frontiers in Immunology. Frontiers Media S.A.. 10. 1-13.
Status: Published
Eriksson, O., Mohlin, C., Nilsson, B., Nilsson Ekdahl, K. (2019). The Human Platelet as an Innate Immune Cell : Interactions Between Activated Platelets and the Complement System. Frontiers in Immunology. Frontiers Media S.A.. 10. 1-16.
Status: Published
Huber-Lang, M., Nilsson Ekdahl, K., Wiegner, R., Fromell, K., Nilsson, B. (2018). Auxiliary activation of the complement system and its importance for the pathophysiology of clinical conditions. Seminars in Immunopathology. Springer. 40 (1). 87-102.
Status: Published
Biglarnia, A., Huber-Lang, M., Mohlin, C., Nilsson Ekdahl, K., Nilsson, B. (2018). The multifaceted role of complement in kidney transplantation. Nature Reviews Nephrology. Nature Publishing Group. 14 (12). 767-781.
Status: Published
Nilsson Ekdahl, K., Persson, B., Mohlin, C., Sandholm, K., Skattum, L., et al. (2018). Interpretation of Serological Complement Biomarkers in Disease. Frontiers in Immunology. Frontiers Media S.A.. 9.
Status: Published
Mohlin, C., Sandholm, K., Nilsson Ekdahl, K., Nilsson, B. (2017). The link between morphology and complement in ocular disease. Molecular Immunology. Elsevier. 89. 84-99.
Status: Published
Nilsson Ekdahl, K., Soveri, I., Hilborn, J., Fellström, B., Nilsson, B. (2017). Cardiovascular disease in haemodialysis : role of the intravascular innate immune system. Nature Reviews Nephrology. Nature Publishing Group. 13 (5). 285-296.
Status: Published
Nilsson Ekdahl, K., Teramura, Y., Hamad, O.A., Asif, S., Duehrkop, C., et al. (2016). Dangerous liaisons : complement, coagulation, and kallikrein/kinin cross-talk act as a linchpin in the events leading to thromboinflammation. Immunological Reviews. 274 (1). 245-269.
Status: Published
Barbu, A., Hamad, O., Lind, L., Nilsson Ekdahl, K., Nilsson, B. (2015). The role of complement factor C3 in lipid metabolism. Molecular Immunology. Elsevier. 67 (1). 101-107.
Status: Published
Speth, C., Rambach, G., Wuerzner, R., Lass-Floerl, C., Kozarcanin, H., et al. (2015). Complement and platelets : Mutual interference in the immune network. Molecular Immunology. 67 (1). 108-118.
Status: Published
Nilsson, B., Teramura, Y., Nilsson Ekdahl, K. (2014). The role and regulation of complement activation as part of the thromboinflammation elicited in cell therapies. Molecular Immunology. 61 (2). 185-190.
Status: Published
Nilsson, B., Nilsson Ekdahl, K. (2012). Complement Diagnostics : Concepts, Indications, and Practical Guidelines. Clinical & Developmental Immunology.
Status: Published
Nilsson, B., Nilsson Ekdahl, K. (2012). The tick-over theory revisited : Is C3 a contact-activated protein?. Immunobiology. 217 (11). 1106-1110.
Status: Published
Sartz, L., Olin, A., Kristoffersson, A., Ståhl, A., Johansson, M., et al. (2012). A novel C3 mutation causing increased formation of the C3 convertase in familial atypical hemolytic uremic syndrome.. Journal of Immunology. 188 (4). 2030-2037.
Status: Published
Biglarnia, A.R., Nilsson, B., Nilsson Ekdahl, K., Tufveson, G., Nilsson, T., et al. (2012). Desenzitation Protocol with Antigen-Specific Immunoadsorption Interferes with Complement in ABO Incompatible Renal Transplantation. Transplantation. 93 (1). 87-92.
Status: Published
Norda, R., Schött, U., Berséus, O., Åkerblom, O., Nilsson, B., et al. (2012). Complement activation products in liquid stored plasma and C3a-kinetics after transfusion of autologous plasma. Vox Sanguinis. 102 (2). 125-133.
Status: Published
Nilsson Ekdahl, K., Lambris, J., Elwing, H., Ricklin, D., Nilsson, P.H., et al. (2011). Innate immunity activation on biomaterial surfaces: A mechanistic model and coping strategies. Advanced Drug Delivery Reviews. 63 (12). 1042-1050.
Status: Published
Nilsson, B., Nilsson Ekdahl, K., Korsgren, O. (2011). Control of IBMIR (Instant Blood-Mediated Inflammatory Reaction) to improve islets of Langerhans engraftement. Current Opinion in Organ Transplantation. 16 (6). 620-626.
Status: Published
Babiker, A.A., Ronquist, G., Nilsson, B., Nilsson Ekdahl, K. (2010). Prostasome Involvement in the Development and of Prostate Cancer. Open Prostate Cancer Journal. 3. 1-13.
Status: Published

Article in journal (Other academic)

Fromell, K., Johansson, U., Duhrkop, C., Adler, A., Usterud, E., et al. (2018). Generation of an alternative pathway convertase by contact-activated C3 is dependent on the conformation of C3. Molecular Immunology. 102. 193-193.
Status: Published
Mohlin, C., Petrus-Reurer, S., Lanner, F., Sandholm, K., Nilsson, P.H., et al. (2018). Is the polarized secretion of complement factor H of importance in age-related macular degeneration?. Investigative Ophthalmology and Visual Science. 59 (9).
Status: Published
Fromell, K., Duhrkop, C., Kozarcanin, H., Johansson, U., Skjoedt, M., et al. (2018). The lectin pathway of complement and the contact/kallikrein system are integrated. Molecular Immunology. 102. 151-152.
Status: Published
Nilsson, B., Asif, S., Nilsson Ekdahl, K., Manell, E., Biglarnia, A., et al. (2017). A protective role of complement regulators linked to a PEG phospholipid construct in reducing ischemic reperfusion injury in transplantation. Molecular Immunology. 89. 208-208.
Status: Published
Fromell, K., Duhrkop, C., Johansson, U., Nilsson Ekdahl, K., Nilsson, B. (2017). Forms of contact-activated C3 associated with AP convertase formation. Molecular Immunology. 89. 141-141.
Status: Published
Mohlin, C., Petrus-Reurer, S., Lanner, F., Sandholm, K., Kvanta, A., et al. (2017). Complement system proteins in human embryonic stem cell-derived retinal pigment epithelial cells co-cultured with or without porcine retina. Molecular Immunology. 89. 162-163.
Status: Published
Nilsson Ekdahl, K., Teramura, Y., Asir, S., Manell, E., Biglarnia, A., et al. (2016). Protective role of PEG conjugated phospholipid in reducing ischemic reperfusion injury in two allogeneic pig kidney transplant models. Immunobiology. 221 (10). 1184-1184.
Status: Published
Ricklin, D., Sfyroera, G., Reis, E., Chen, H., Wu, E., et al. (2015). Rare loss-of-function mutation in C3 provides insight into molecular and pathophysiological determinants of alternative pathway activity. Molecular Immunology. 67 (1). 174-174.
Status: Published
Jonsson, N., Asif, S., Teramura, Y., Gustafson, E., Nilsson Ekdahl, K., et al. (2015). Surface modification of primary human hepatocytes with recombinant CD39 protects against thromboinfiammation. Molecular Immunology. 67 (1). 149-150.
Status: Published
Teramura, Y., Asif, S., Gustafson, E., Nilsson Ekdahl, K., Nilsson, B. (2015). Heparinzation of cell surfaces with a heparin-binding peptide-conjugated PEG-lipid for regulation of thromboinflammation in transplantation of human MSC and hepatocyte. Xenotransplantation. 22 (Supplement 1). S70-S70.
Status: Published
Carlsson, H., Sandholm, K., Tjernberg, I., Nilsson Ekdahl, K. (2015). Complement activation in asymptomatic Lyme borreliosis and neuroborreliosis. Molecular Immunology. 67 (1). 128-128.
Status: Published
Nilsson, B., Nilsson Ekdahl, K., Kemper, C., Mollnes, T.E. (2015). Preface. 15th European Meeting on Complement in Human Disease 2015, Uppsala, Sweden.. Molecular Immunology. 67 (1). 1-2.
Status: Published
Sandholm, K., Wijkstrom, E., Skattum, L., Nilsson, B., Nilsson Ekdahl, K. (2015). Validations of assays for the evaluation of C1q in inflammatory diseases and thromboinflammation. Molecular Immunology. 67 (1). 176-177.
Status: Published
Mohlin, C., Johansson, K., Nilsson Ekdahl, K. (2015). Complement factor involvement during experimental AMD. Molecular Immunology. 67 (1). 163-163.
Status: Published
Huang, S., Sandholm, K., Nilsson, B., Nilsson Ekdahl, K. (2015). iC3 generation elicited by the presence of ammonia and urea in human plasma. Molecular Immunology. 67 (1). 145-145.
Status: Published
Kozarcanin, H., Lood, C., Munthe-Fog, L., Sandholm, K., Hamad, O., et al. (2015). The lectin complement pathway serine proteases bridges the complement and the coagulation systems in thrombotic diseases. Molecular Immunology. 67 (1). 153-153.
Status: Published
Asif, S., Jonsson, N., Teramura, Y., Gustafson, E., Nilsson Ekdahl, K., et al. (2015). Conjugation of human recombinant CD39 to primary human hepatocytes protects against thromboinflammation. Xenotransplantation. 22. S87-S87.
Status: Published
Engberg, A.E., Nilsson, P.H., Sandholm, K., Huang, S., Mollnes, T.E., et al. (2013). The ratio between C4 and C4BP adsorbed to artificial materials is a new predictor for biocompatibility. Molecular Immunology. 56 (3). 309-309.
Status: Published
Hancock, V., Huang, S., Nilsson, A., Grundstrom, G., Nilsson Ekdahl, K. (2013). Citrate reduces complement and leukocyte activation in vitro in human blood. Nephrology, Dialysis and Transplantation. 28. 207-208.
Status: Published
Sandholm, K., Henningsson, A.J., Bergstrom, S., Ernerudh, J., Nilsson Ekdahl, K. (2012). Complement activation and phagocytosis in vitro of two strains of Borrelia burgdorferi S.L. Immunobiology. 217 (11). 1153-1153.
Status: Published
Hamad, O.A., Nilsson Ekdahl, K., Nilsson, B. (2012). Non-proteolytically activated C3 promotes binding of activated platelets and platelet-derived microparticles to leukocytes via CD11b/CD18. Immunobiology. 217 (11). 1191-1191.
Status: Published
Huang, S., Nilsson, P.H., Sandholm, K., Elmlund, L., Nicholls, I.A., et al. (2012). Regulation of complement in whole blood by heparin molecularly imprinted polymer particles. Immunobiology. 217 (11). 1199-1199.
Status: Published
Klapper, Y., Hamad, O., Teramura, Y., Leneweit, G., Nienhaus, G.U., et al. (2012). Investigation of complement activation by neutral liposomes. Immunobiology. 217 (11). 1179-1180.
Status: Published
Engberg, A.E., Nilsson, P.H., Mollnes, T.E., Rosengren-Holmberg, J.P., Nicholls, I.A., et al. (2012). The ratio between C4 and C4BP adsorbed from plasma predicts cytokine generation induced by artificial polymers in contact with whole blood. Immunobiology. 217 (11). 1211-1211.
Status: Published
Teramura, Y., Nilsson, P.H., Nilsson Ekdahl, K., Magnusson, P.U., Qu, H., et al. (2012). Autoregulation of thromboinflammation on biomaterials and cells by a novel therapeutic coating technique. Immunobiology. 217 (11). 1140-1140.
Status: Published
Nilsson, U., Funke, L., Nilsson, B., Nilsson Ekdahl, K. (2010). Two conformational forms of target bound iC3b which distinctively bind complement receptors 1 and 2 (CR1 and CR2) and two specific monoclonal antibodies.. Upsala Journal of Medical Sciences, Supplement.
Status: Published

Chapter in book (Other academic)

Nilsson, B., Nilsson Ekdahl, K. (1988). Components of the alternative pathway. The Complement System. Springer. 23-49.

Article, review/survey (Other academic)

Nilsson Ekdahl, K., Nilsson, B. (2018). Hemodialys, inflammation och det naturliga immunsystemet. Vaskulär Medicin. Svensk förening för hypertoni, stroke och vaskulär medicin. 34 (3). 17-21.
Status: Published
Rönnelid, J., Åhlin, E., Nilsson, B., Nilsson Ekdahl, K., Mathsson, L. (2008). Immune complex-mediated cytokine production is regulated by classical complement activation both in vivo and in vitro. Advances in experimental medicine and biology. 632. 187-201.
Status: Published

Doctoral thesis, comprehensive summary (Other academic)

Nilsson Ekdahl, K. (1987). Studies on the regulation of rat liver pyruvate kinase and fructose 1,6-bisphosphatase. Doctoral Thesis. Uppsala, Acta Universitatis Upsaliensis. 41.

Manuscript (preprint) (Other academic)

Engberg, A.E., Rosengren-Holmberg, J.P., Nilsson, P.H., Bäck, ., Mollnes, T.E., et al. EVALUATION OF THE HEMOCOMPATIBILITY OF NOVEL POLYMERIC MATERIALS.
Huang, S., Sandholm, K., Jonsson, N., Rorsman, F., Nilsson, B., et al. An assay to monitor in vitro generation of non-proteolytically activated C3 in human plasma.

Article in journal (Other (popular science, discussion, etc.))

Nilsson Ekdahl, K. (2001). Magisterprogrammet i biomedicin. Klinisk kemi. 1. 34-35.
Status: Published
Nilsson Ekdahl, K. (2000). Biomedicinsk kemi. Klinisk kemi. 5. 151-152.
Status: Published

Patent (Other (popular science, discussion, etc.))

Nicholls, I.A., Nilsson Ekdahl, K. (2009). Moledcular Imprints.
Nilsson, B., Andersson, J., Neff, J., Caldwell, K., Nilsson Ekdahl, K. (2005). Elutable Surface coatings.
Nilsson Ekdahl, K., Nilsson, B., Andersson, J., Neff, J., Caldwell, K. (2004). Surface coating comprising bioactive compound.