Per Nilsson

Associate professor

Department of Chemistry and Biomedical Sciences Faculty of Health and Life Sciences

per.h.nilsson@lnu.se

+46 480-44 61 26

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My research groups

Host Response to Biomaterials Laboratory (HoRB) In the Host Response to Biomaterials Laboratory research group, we study the reactions that occur in contact between blood and biomaterials. The goal is…
Linnaeus University Centre for Biomaterials Chemistry Linnaeus University Centre for Biomaterials Chemistry is a principal research environment that deals with the development and the adaptation of…

My ongoing research projects

Publications

Article in journal (Refereed)

Grimaldi, M.C., Bozzer, S., Sjöström, D.J., Andersson, L., Mollnes, T.E., et al. (2025). DNA-loaded targeted nanoparticles as a safe platform to produce exogenous proteins in tumor B cells. Frontiers in Immunology. 15.
Status: Published
Andersson, L., Sjöström, D.J., Brandwijk, R.J., Toonen, E.J., Mollnes, T.E., et al. (2025). Complement function and activation in human serum and plasma collected in different blood collection tubes. JIM - Journal of Immunological Methods. 538. 113825-113825.
Status: Published
Louwe, M.C., Gialeli, C., Michelsen, A.E., Holm, S., Edsfeldt, A., et al. (2025). Alternative Complement Pathway in Carotid Atherosclerosis : Low Plasma Properdin Levels Associate With Long-Term Cardiovascular Mortality. Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease. 14 (3).
Status: Published
Andersson, L., Sjöström, D.J., Quach, H.Q., Hägerström, K., Hurler, L., et al. (2024). Storage of Transfusion Platelet Concentrates is Associated with Complement Activation and Reduced Ability of Platelets to Respond to Protease-Activated Receptor-1 and Thromboxane A2 Receptor. International Journal of Molecular Sciences. 25 (2).
Status: Published
Nilsson, P.H., Al-Majdoub, M., Ibrahim, A., Aseel, O., Suriyanarayanan, S., et al. (2023). Quartz Crystal Microbalance Platform for SARS-CoV-2 Immuno-Diagnostics. International Journal of Molecular Sciences. 24 (23).
Status: Published
Chaban, V., De Boer, E., Mcadam, K.E., Vaage, J., Mollnes, T.E., et al. (2023). Escherichia coli-induced inflammatory responses are temperature-dependent in human whole blood ex vivo. Molecular Immunology. 157. 70-77.
Status: Published
Gerogianni, A., Baas, L.M., Sjöström, D.J., Van De Kar, N.C.A.J., Pullen, M., et al. (2023). Functional evaluation of complement factor I variants by immunoassays and SDS-PAGE. Frontiers in Immunology. 14.
Status: Published
Flockhart, M., Nilsson, L.C., Tillqvist, E.N., Vinge, F., Millbert, F., et al. (2023). Glucosinolate-rich broccoli sprouts protect against oxidative stress and improve adaptations to intense exercise training. Redox Biology. 67.
Status: Published
Gerogianni, A., Bal, M., Mohlin, C., Woodruff, T.M., Lambris, J.D., et al. (2023). In vitro evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model. Frontiers in Immunology. 14.
Status: Published
Weber, F., Quach, H.Q., Reiersen, M., Sarraj, S.Y., Bakir, D.N., et al. (2022). Characterization of the foreign body response of titanium implants modified with polyphenolic coatings. Journal of Biomedical Materials Research. Part A. 110 (7). 1341-1355.
Status: Published
Johnson, C., Quach, H.Q., Lau, C., Ekholt, K., Espevik, T., et al. (2022). Thrombin Differentially Modulates the Acute Inflammatory Response to Escherichia coli and Staphylococcus aureus in Human Whole Blood. Journal of Immunology. 208 (12). 2771-2778.
Status: Published
Gerogianni, A., Dimitrov, J.D., Zarantonello, A., Poillerat, V., Chonat, S., et al. (2022). Heme Interferes With Complement Factor I-Dependent Regulation by Enhancing Alternative Pathway Activation. Frontiers in Immunology. 13.
Status: Published
Torp, M., Ranheim, T., Schjalm, C., Hjorth, M., Heiestad, C.M., et al. (2022). Intracellular Complement Component 3 Attenuated Ischemia-Reperfusion Injury in the Isolated Buffer-Perfused Mouse Heart and Is Associated With Improved Metabolic Homeostasis. Frontiers in Immunology. 13.
Status: Published
De Boer, E., Sokolova, M., Quach, H.Q., Mcadam, K.E., Gotz, M.P., et al. (2022). Synthetic Oligodeoxynucleotide CpG Motifs Activate Human Complement through Their Backbone Structure and Induce Complement-Dependent Cytokine Release. Journal of Immunology. 209 (9). 1760-1767.
Status: Published
Brandwijk, R.J.M.G.E., Michels, M.A.H.M., Van Rossum, M., De Nooijer, A.H., Nilsson, P.H., et al. (2022). Pitfalls in complement analysis : A systematic literature review of assessing complement activation. Frontiers in Immunology. 13.
Status: Published
Quach, H.Q., Johnson, C., Ekholt, K., Islam, R., Mollnes, T.E., et al. (2022). Platelet-Depletion of Whole Blood Reveals That Platelets Potentiate the Release of IL-8 From Leukocytes Into Plasma in a Thrombin-Dependent Manner. Frontiers in Immunology. 13.
Status: Published
Landsem, A., Emblem, A., Lau, C., Christiansen, D., Gerogianni, A., et al. (2022). Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood. Frontiers in Immunology. 13.
Status: Published
Islam, R., Islam, M.M., Nilsson, P.H., Mohlin, C., Hagen, K.T., et al. (2021). Combined blockade of complement C5 and TLR co-receptor CD14 synergistically inhibits pig-to-human corneal xenograft induced innate inflammatory responses. Acta Biomaterialia. 127. 169-179.
Status: Published
Sharifi, S., Islam, M.M., Sharifi, H., Islam, R., Koza, D., et al. (2021). Tuning gelatin-based hydrogel towards bioadhesive ocular tissue engineering applications. Bioactive Materials. 6 (11). 3947-3961.
Status: Published
Holt, M.F., Michelsen, A.E., Shahini, N., Bjorkelund, E., Bendz, C.H., et al. (2021). The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure. Frontiers in Immunology. 12.
Status: Published
Sharifi, S., Islam, M.M., Sharifi, H., Islam, R., Huq, T.N., et al. (2021). Electron Beam Sterilization of Poly(Methyl Methacrylate)-Physicochemical and Biological Aspects. Macromolecular Bioscience. 21 (4).
Status: Published
Nilsson, P.H., Johnson, C., Quach, Q.H., Macpherson, A., Durrant, O., et al. (2021). A Conformational Change of Complement C5 Is Required for Thrombin-Mediated Cleavage, Revealed by a Novel Ex Vivo Human Whole Blood Model Preserving Full Thrombin Activity. Journal of Immunology. 207 (6). 1641-1651.
Status: Published
Zhu, G.H., Azharuddin, M., Islam, R., Rahmoune, H., Deb, S., et al. (2021). Innate Immune Invisible Ultrasmall Gold Nanoparticles-Framework for Synthesis and Evaluation. ACS Applied Materials and Interfaces. 13 (20). 23410-23422.
Status: Published
Macpherson, A., Laabei, M., Ahdash, Z., Graewert, M.A., Birtley, J.R., et al. (2021). The allosteric modulation of complement C5 by knob domain peptides. eLIFE. 10.
Status: Published
Shahini, N., Schjalm, C., Nilsson, P.H., Holt, M.F., Ogaard, J.D.S., et al. (2020). Complement component C3 and the TLR co-receptor CD14 are not involved in angiotensin II induced cardiac remodelling. Biochemical and Biophysical Research Communications - BBRC. 523 (4). 867-873.
Status: Published
Sharifi, S., Islam, M.M., Sharifi, H., Islam, R., Nilsson, P.H., et al. (2020). Sputter Deposition of Titanium on Poly(Methyl Methacrylate) Enhances Corneal Biocompatibility. Translational Vision Science & Technology. 9 (13). 1-14.
Status: Published
Tjernberg, A.R., Woksepp, H., Sandholm, K., Johansson, M., Dahle, C., et al. (2020). Celiac disease and complement activation in response to Streptococcus pneumoniae. European Journal of Pediatrics. 179 (1). 133-140.
Status: Published
Islam, M.M., Sharifi, R., Mamodaly, S., Islam, R., Nahra, D., et al. (2019). Effects of gamma radiation sterilization on the structural and biological properties of decellularized corneal xenografts. Acta Biomaterialia. 96. 330-344.
Status: Published
Thomas, A.M., Gerogianni, A., Mcadam, M.B., Floisand, Y., Lau, C., et al. (2019). Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood. Journal of Immunology. 203 (6). 1571-1578.
Status: Published
Shahini, N., Ueland, T., Auensen, A., Michelsen, A.E., Ludviksen, J.K., et al. (2019). Increased Complement Factor B and Bb Levels Are Associated with Mortality in Patients with Severe Aortic Stenosis. Journal of Immunology. 203 (7). 1973-1980.
Status: Published
Holt, M., Seim, B.E., Ogaard, J., Olsen, M.B., Woldbaek, P.R., et al. (2019). Selective and marked decrease of complement receptor C5aR2 in human thoracic aortic aneurysms : a dysregulation with potential inflammatory effects. Open heart. 6 (2). 1-8.
Status: Published
Thorgersen, E.B., Barratt-Due, A., Haugaa, H., Harboe, M., Pischke, S.E., et al. (2019). The Role of Complement in Liver Injury, Regeneration, and Transplantation. Hepatology. 70 (2). 725-736.
Status: Published
Orrem, H.L., Nilsson, P.H., Pischke, S.E., Grindheim, G., Garred, P., et al. (2018). Acute heart failure following myocardial infarction : complement activation correlates with the severity of heart failure in patients developing cardiogenic shock.. ESC Heart Failure. 5 (3). 292-301.
Status: Published
Orrem, H.L., Nilsson, P.H., Pischke, S.E., Kleveland, O., Yndestad, A., et al. (2018). IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction. Frontiers in Immunology. 9.
Status: Published
Thomas, A.M., Schjalm, C., Nilsson, P.H., Lindenskov, P.H.H., Rørtveit, R., et al. (2018). Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome.. Neonatology. 113 (4). 322-330.
Status: Published
Orrem, H.L., Shetelig, C., Ueland, T., Limalanathan, S., Nilsson, P.H., et al. (2018). Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction. International Journal of Cardiology. 268. 187-192.
Status: Published
Orrem, H.L., Nilsson, P.H., Pischke, S.E., Kleveland, O., Ekholt, K., et al. (2017). The IL-6 receptor inhibitor tocilizumab attenuated expression of C5a receptor 1 and 2 in patients with myocardial infarction. Molecular Immunology. 89. 128-128.
Status: Published
Nilsson, P.H., Thomas, A.M., Bergseth, G., Gustavsen, A., Volokhina, E.B., et al. (2017). Eculizumab-C5 complexes express a C5a neoepitope in vivo : Consequences for interpretation of patient complement analyses. Molecular Immunology. 89. 111-114.
Status: Published
Bergseth, G., Nilsson, P.H., Thomas, A.M., Gustavsen, A., Volokhina, E.B., et al. (2017). Neoepitope based assays to detect C5a – Pitfalls and interpretations. Molecular Immunology. 89 (SI: EMCHD2017). 201-201.
Status: Published
Thomas, A.M., Schjalm, C., Nilsson, P.H., Lindenskov, P.H.H., Rørtveit, R., et al. (2017). Combined inhibition of C5 and CD14 attenuates systemic inflammation in a newborn pig-model of meconium aspiration syndrome. Molecular Immunology. 89 (SI: EMCHD2017). 166-167.
Status: Published
Barratt-Due, A., Pischke, S.E., Nilsson, P.H., Espevik, T., Mollnes, T.E. (2017). Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases-C3 or C5 emerge together with CD14 as promising targets.. Journal of Leukocyte Biology. 101 (1). 193-204.
Status: Published
Wibroe, P.P., Anselmo, A.C., Nilsson, P.H., Sarode, A., Gupta, V., et al. (2017). Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes.. Nature Nanotechnology. 12 (6). 589-594.
Status: Published
Nilsson, P.H., Johnson, C., Pischke, S.E., Fure, H., Landsem, A., et al. (2017). Characterization of a novel whole blood model for the study of thrombin in complement activation and inflammation. Molecular Immunology. 89 (SI: EMCHD2017). 136-137.
Status: Published
Harboe, M., Johnson, C., Nymo, S., Ekholt, K., Schjalm, C., et al. (2017). Properdin binding to complement activating surfaces depends on initial C3b deposition. Proceedings of the National Academy of Sciences of the United States of America. 114 (4). E534-E539.
Status: Published
Shahini, N., Michelsen, A.E., Nilsson, P.H., Ekholt, K., Gullestad, L., et al. (2017). The alternative complement pathway is dysregulated in patients with chronic heart failure. Molecular Immunology. 89 (SI: EMCHD2017). 127-127.
Status: Published
Shahini, N., Michelsen, A.E., Nilsson, P.H., Ekholt, K., Gullestad, L., et al. (2017). The alternative complement pathway is dysregulated in patients with chronic heart failure. Scientific Reports. 7. 1-10.
Status: Published
Harboe, M., Johnson, C., Nymo, S., Ekholt, K., Schjalm, C., et al. (2016). Molecular modelling showed optimal fit between TSR5 in trimeric properdin and C345C in the C3b moiety for stabilization of the alternative convertase, whereas binding to molecular patterns in myeloperoxidase, endothelial cells and Neisseria meningitides was indirectly mediated by initial C3 activation. Immunobiology. 221 (10). 1205-1205.
Status: Published
Otterdal, K., Portillo, A., Astrup, E., Ludviksen, J.K., Schjalm, C., et al. (2016). Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo. Immunobiology. 221 (10). 1204-1205.
Status: Published
Otterdal, K., Portillo, A., Astrup, E., Ludviksen, J.K., Schjalm, C., et al. (2016). Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo.. Clinical Microbiology and Infection. 22 (8). 734.e1-734.e6.
Status: Published
Nymo, S., Gustavsen, A., Nilsson, P.H., Lau, C., Espevik, T., et al. (2016). Human Endothelial Cell Activation by Escherichia coli and Staphylococcus aureus Is Mediated by TNF and IL-1 beta Secondarily to Activation of C5 and CD14 in Whole Blood. Journal of Immunology. 196 (5). 2293-2299.
Status: Published
Orrem, H.L., Nilsson, P.H., Barratt-Due, A., Pische, S.E., Grindheim, G., et al. (2016). Complement activation in acute heart failure following myocardial infarction. Immunobiology. 221 (10). 1203-1204.
Status: Published
Otterdal, K., Portillo, A., Astrup, E., Ludviksen, J., Davì, G., et al. (2016). High serum CXCL10 in Rickettsia conorii infection is endothelial cell mediated subsequent to whole blood activation.. Cytokine. 83. 269-274.
Status: Published
Fretland, A.A., Sokolov, A., Postriganova, N., Kazaryan, A.M., Pischke, S.E., et al. (2015). Inflammatory Response After Laparoscopic Versus Open Resection of Colorectal Liver Metastases : Data From the Oslo-CoMet Trial.. Medicine. 94 (42). 1-7.
Status: Published
Engberg, A.E., Nilsson, P.H., Huang, S., Fromell, K., Hamad, O.A., et al. (2015). Prediction of inflammatory responses induced by biomaterials in contact with human blood using protein fingerprint from plasma. Biomaterials. 36. 55-65.
Status: Published
Berg, A., Otterdal, K., Patel, S., Gonca, M., David, C., et al. (2015). Complement Activation Correlates With Disease Severity and Contributes to Cytokine Responses in Plasmodium falciparum Malaria.. Journal of Infectious Diseases. 212 (11). 1835-1840.
Status: Published
Harboe, M., Nilsson, P.H., Johnson, C., Lindstad, J.K., Pharo, A., et al. (2015). Binding of properdin to myeloperoxidase and Neisseria meningitidis is C3-dependent. Molecular Immunology. 67 (1, Special Issue). 142-142.
Status: Published
Nilsson, P.H., Berg, A., Otterdal, K., Patel, S., Gonca, M., et al. (2014). Complement-dependent inflammatory response Plasmodium-derived hemozoin in malaria. Molecular Immunology. 61 (2). 230-230.
Status: Published
Huber-Lang, M., Barratt-Due, A., Pischke, S.E., Sandanger, Ø., Nilsson, P.H., et al. (2014). Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice.. Journal of Immunology. 192 (11). 5324-5331.
Status: Published
Ehrnthaller, C., Huber-Lang, M., Nilsson, P.H., Bindl, R., Redeker, S., et al. (2013). Complement C3 and C5 deficiency affects fracture healing.. PLOS ONE. 8 (11).
Status: Published
Nilsson, P.H., Nilsson Ekdahl, K., Magnusson, P.U., Qu, H., Iwata, H., et al. (2013). Autoregulation of thromboinflammation on biomaterial surfaces by a multicomponent therapeutic coating. Biomaterials. 34 (4). 985-994.
Status: Published
Mollnes, T.E., Nilsson, P.H. (2013). Letter to the Editor.. Journal of clinical biochemistry and nutrition. 52 (3). 253-254.
Status: Published
Mollnes, T., Baratt-Due, A., Pischke, S., Sandanger, I., Nilsson, P.H., et al. (2013). Double-blockade of CD14 and complement component C5 abolish the inflammatory storm and improve survival in mouse polymicrobial sepsis. Molecular Immunology. 56 (3). 294-294.
Status: Published
Nilsson, P.H., Engberg, A.E., Bäck, J., Faxälv, L., Lindahl, T., et al. (2010). The creation of an antithrombotic surface by apyrase immobilization. Biomaterials. 31 (16). 4484-4491.
Status: Published
Hamad, O., Nilsson, P.H., Wouters, D., Lambris, J., Nilsson Ekdahl, K., et al. (2010). Complement Component C3 Binds to Activated Normal Platelets without Preceding Proteolytic Activation and Promotes Binding to Complement Receptor 1. Journal of Immunology. 184 (5). 2686-2692.
Status: Published
Hamad, O.A., Nilsson, P.H., Lasaosa, M., Ricklin, D., Lambris, J.D., et al. (2010). Contribution of Chondroitin Sulfate A to the Binding of Complement Proteins to Activated Platelets. PLOS ONE. 5 (9).
Status: Published
Hamad, O., Nilsson, P.H., Lambris, J.D., Nilsson Ekdahl, K., Nilsson, B. (2009). Binding of complement proteins to activated platelets is independent of complement activation. Molecular Immunology. 46 (14). 2853-2853.
Status: Published
Hamad, O.A., Nilsson Ekdahl, K., Nilsson, P.H., Andersson, J., Magotti, P., et al. (2008). Complement activation triggered by chondroitin sulfate reelased by thrombin receptor-activated platelets. Journal of Thrombosis and Haemostasis. 6 (8). 1413-1421.
Status: Published

Conference paper (Refereed)

Hamad, O., Bäck, J., Nilsson, P.H., Nilsson, B., Nilsson Ekdahl, K. (2012). Platelets, Complement, and Contact Activation : Partners in inflammation and thrombosis. Current Topics in Innate Immunity II. 185-205.

Chapter in book (Refereed)

Nilsson, P.H., Pettersen, K., Oppermann, M., Skjeflo, E.W., Fure, H., et al. (2021). Quantification of Porcine Complement Activation Fragment C3a by a Neoepitope-Based Enzyme-Linked Immunosorbent Assay. The Complement System : Innovative Diagnostic and Research Protocols. Springer. 51-59.
Mahmoudi, M., Nilsson, P.H., Mollnes, T.E., Roos, D., Sullivan, K.E. (2017). Complement Deficiencies. Primary Immunodeficiency Diseases : Definition, Diagnosis, and Management. Berlin, Heidelberg, Springer. 437-460.

Article, review/survey (Refereed)

Mollnes, T.E., Storm, B.S., Brekke, O.L., Nilsson, P.H., Lambris, J.D. (2022). Application of the C3 inhibitor compstatin in a human whole blood model designed for complement research-20 years of experience and future perspectives. Seminars in Immunology. Elsevier. 59.
Status: Published
Nilsson Ekdahl, K., Lambris, J., Elwing, H., Ricklin, D., Nilsson, P.H., et al. (2011). Innate immunity activation on biomaterial surfaces: A mechanistic model and coping strategies. Advanced Drug Delivery Reviews. 63 (12). 1042-1050.
Status: Published

Article in journal (Other academic)

Nilsson, P.H., Skattum, L., Toonen, E.J.M. (2023). Current challenges in complement diagnostics. Frontiers in Immunology. 14.
Status: Published
Mohlin, C., Petrus-Reurer, S., Lanner, F., Sandholm, K., Nilsson, P.H., et al. (2018). Is the polarized secretion of complement factor H of importance in age-related macular degeneration?. Investigative Ophthalmology and Visual Science. 59 (9).
Status: Published
Thomas, A.M., Gerogianni, A., Barratt-Due, A., Mcadam, M.B., Mollnes, T.E., et al. (2018). Complement (C5)-inhibition attenuates heme-induced inflammation in human whole blood. Molecular Immunology. 102. 220-220.
Status: Published
Engberg, A.E., Nilsson, P.H., Sandholm, K., Huang, S., Mollnes, T.E., et al. (2013). The ratio between C4 and C4BP adsorbed to artificial materials is a new predictor for biocompatibility. Molecular Immunology. 56 (3). 309-309.
Status: Published
Huang, S., Nilsson, P.H., Sandholm, K., Elmlund, L., Nicholls, I.A., et al. (2012). Regulation of complement in whole blood by heparin molecularly imprinted polymer particles. Immunobiology. 217 (11). 1199-1199.
Status: Published
Engberg, A.E., Nilsson, P.H., Mollnes, T.E., Rosengren-Holmberg, J.P., Nicholls, I.A., et al. (2012). The ratio between C4 and C4BP adsorbed from plasma predicts cytokine generation induced by artificial polymers in contact with whole blood. Immunobiology. 217 (11). 1211-1211.
Status: Published
Teramura, Y., Nilsson, P.H., Nilsson Ekdahl, K., Magnusson, P.U., Qu, H., et al. (2012). Autoregulation of thromboinflammation on biomaterials and cells by a novel therapeutic coating technique. Immunobiology. 217 (11). 1140-1140.
Status: Published

Doctoral thesis, comprehensive summary (Other academic)

Nilsson, P.H. (2012). Interactions between platelets and complement with implications for the regulation at surfaces. Doctoral Thesis. Växjö, Kalmar, Linnaeus University Press. 87.

Manuscript (preprint) (Other academic)

Engberg, A.E., Rosengren-Holmberg, J.P., Nilsson, P.H., Bäck, ., Mollnes, T.E., et al. EVALUATION OF THE HEMOCOMPATIBILITY OF NOVEL POLYMERIC MATERIALS.
Gerogianni, A., Sørensen, G., Nilsen Hoel, T., Mcadam, K.E., Ludviksen, J.A., et al. Implantation of a continuous-flow left ventricular assist device is associated with a significant but transient acute thromboinflammatory response.