In this seminar Dr Sinisa Bjelic will present what they have learned from their efforts to discover covalently modifiable sites, challenges in using such sites for inhibitor development in cancer, and the surprising effects that modifications may have on protein function.
Chemical modification of proteins is a broad research area involving posttranslational modifications, bioconjugation, covalent drugs, toxicology, and biocatalysis. Such modifications are consequently used in diverse applications from altering protein function to monitoring cellular events. Despite that we have gained a lot of understanding about chemical modifications, we are still missing in current approaches the ability to successfully predict covalently modifiable sites and their impact on function. It would be desirable to locate these sites in a protein so that we can for example inhibit enzyme function upon covalent binding or allow for an exogenous molecule to be attached for tracking in cells.
Date: March 29
Time: 13:00-13:35
Location: Room Azur (Vi2166), 2nd floor, Vita, Norra Kajplan 6
The seminar is in English and will be available later on LnuPlay