Välkommen till en föreläsning i fakulteten för hälso- och livsvetenskaps seminarieserie där vi presenterar aktuell forskning inom det naturvetenskapliga området och inom vård och hälsa.
Docent Björn Karlsson, Institutionen för kemi och biomedicin, Linnéuniversitetet
Short-fragment peptides as targets in the development of therapeutic and diagnostic strategies against neurodegenerative disease
Alpha-synuclein (aS) is an intrinsically disordered protein that has been suggested to regulate synaptic vesicle trafficking. Although the misfolding of aS into various aggregated forms is believed be a key step in the development of Lewy Body Dementia and Parkinson’s disease, the role of the maturity of aggregated forms of aS on disease progression have not yet been fully characterised. In addition to this limitation, it is today not possible to detect and differentiate between the various aggregated structures of aS found in patient samples. Solving this issue would greatly help in the development of more efficient drug therapies.
In this talk I will present on-going work on attempts to develop methods to characterise the structure and toxicity of formed aggregates but also strategies that can lead to an inhibition of disease progression. Our strategies do not involve full-length aS but instead peptides that are composed of amino acid fragments of aS known to regulate aS aggregation propensity and aggregate structure. We show that by using peptides instead of full-length aS protein we can fine-tune the structural population of aggregates not only to that observed in aS-related disease but also for those structures found in other neurodegenerative disorders.
Datum och tid/Time and date
2 december kl. 13.00-13.40
Sal Azur, Hus Vita, Kalmar och via Zoom: länk till seminariet
Seminariet hålls på engelska.
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