Design–Validate–Translate: Cross-Disciplinary Efforts in Vaccines, Diagnostics, and Therapeutics
Välkommen till ett seminarium med gästforskare Muhammad Yusuf som arrangeras av kunskapsmiljön Avancerade material.
Föreläsare/Lecturer
Dr Muhammad Yusuf, Padjadjaran University, Indonesien
Titel/Title
Design–Validate–Translate: Cross-Disciplinary Efforts in Vaccines, Diagnostics, and Therapeutics
Sammanfattning/Abstract
The development of vaccines, diagnostics, and therapeutics today often requires collaboration between different fields. This study combines computational modeling with laboratory experiments to help move ideas from basic research toward possible applications. The focus includes peptide-based vaccines, recombinant proteins, and antibody fragments.
Several examples illustrate this approach:
- Diphtheria toxoid redesign. A modified toxoid was designed to keep its immunogenicity while reducing the loss of antigenic specificity that can occur during chemical detoxification. The genetically detoxified toxin also retains HB-EGF receptor binding, making it a possible scaffold for cancer-related research.
- COVID-19 yeast-expressed spike. When little structural information was available at the beginning of the pandemic, modeling and stability prediction were used to guide the design and expression of the spike protein in yeast, followed by preclinical evaluation.
- Peptide vaccine repurposing. Molecular dynamics and immunoinformatics helped identify T-cell epitopes for a peptide-based COVID-19 vaccine. Although vaccine development was not continued, the same peptides were later used in an IGRA-like immune monitoring assay.
- scFv design for biosensors. A single-chain antibody fragment (scFv) was designed and produced for a plasmonic biosensor, using formats suitable for low-cost production and point-of-care diagnostics.
A Teaching Factory model also supports this work. This is a university-based pilot facility that produces small, quality-controlled batches of reagents, IVDs, and herbal products. It helps bridge basic research and prototype development, supports clinical validation and regulatory preparation, and focuses on affordability, access, and training so that innovations can reach more people, including underserved communities.
Datum och tid/Time and date
5 september 2025 kl. 13.00-14.00
Plats/Location
Rum Vi2140, hus Vita, Kalmar
Seminariet hålls på engelska.
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