Sustainable design and controlled crystallization of modified phosphate-borate-silicate bioactive glassy materials for tunable degradation and targeted hard and soft tissue regeneration
Välkommen till ett seminarium med gästforskare Natalia Wojcik som arrangeras av kunskapsmiljön Avancerade material.
Föreläsare/Lecturer
Dr Natalia Wojcik, Institute of Nanotechnology and Materials Engineering, Gdańsk University of Technology, Poland
Titel/Title
"Sustainable design and controlled crystallization of modified phosphate-borate-silicate bioactive glassy materials for tunable degradation and targeted hard and soft tissue regeneration"
Sammanfattning/Abstract
Bioactive glasses are among the most promising biomaterials for bone and soft tissue regeneration due to their tunable degradation, bioactivity, and ion-release behavior. This research aims to improve phosphate-based (P), phosphate-borate (P-B) and phosphate-borate-silicate (P-B-Si) bioactive glasses through compositional modification and nano-/micro-crystallization. A wide range of dopants, including Mg, Nb, Zn, Zr, Ce, and Se, was investigated to regulate glass network connectivity, surface reactivity and hydroxyapatite (HAp) formation in vitro. It has been demonstrated that dopants strongly affect both the dissolution rate and the order and amount of ions released into simulated body fluid (SBF/PBS). Controlled nanocrystallization reduces the initial degradation rate by approximately 10% during the first week of immersion. Furthermore, modifiers such as ZrO2 significantly promote the spontanous formation of slowly dissolving crystalline phases, and enhance the inhibitory effect on both Escherichia coli (EC K-12) and methicillin-resistant Staphylococcus aureus (MRSA). For Mg-doped phosphate-borate glasses, enhanced soft tissue regeneration ability was observed, whereas their corresponding glass-ceramics exhibited increased cytotoxicity (tested on HUVECs).
To improve sustainability, natural waste-derived precursors (e.g. eggshells, rice husk and marine shells) were successfully utilized to replace synthetic substrates: SiO2 and CaO. Ongoing studies focus on the incorporation of recycled silicate-based waste, including cosmetic bottles, wine bottles, automotive glass and cemetery candle glass, enabling partial substitution of SiO2, Na2O and CaO. These recycled-derived compositions exhibit improved glass-forming ability and more favorable amorphous structures. Overall, this research provides new design strategies for next-generation, sustainable bioactive materials with tunable degradation for application in hard and soft tissue engineering.
Datum och tid/Time and date
5 november 2025 kl. 14.30-16.00
Plats/Location
Sal Azur, hus Vita, Kalmar
Seminariet hålls på engelska.
Om Kunskapsmiljö Linné: Avancerade material
Det behövs nya typer av material för att möta aktuella och framtida utmaningar inom områden som energi, resurser, hälsovård och livsmedel. Syftet med kunskapsmiljön Avancerade material är att möta denna samhällsutmaning genom att skapa hållbara, funktionella material som möter framtidens behov.