Björn Karlsson

Docent

Institutionen för kemi och biomedicin Fakulteten för hälso- och livsvetenskap

bjorn.karlsson@lnu.se

0480-44 67 40

Hej!
Jag heter Björn C.G. Karlsson och är anställd som universitetslektor i fysikalisk kemi med galenisk farmaci. Sedan 2013 är jag även docent i fysikalisk kemi.

Undervisning

Min undervisning bedriver jag huvudsakligen för studenter på farmaceut-, nutrition och livsmedelsvetenskaps-, biomedicinska analytiker- samt optikerprogrammet.

Utöver undervisning på dessa grundutbildningsprogram så medverkar jag även på kursen Kemi bas A 7,5 fp (0KE002) som är en behörighetsgivande utbildning för studenter som inte har en naturvetenskaplig bakgrund.

Jag är idag kursansvarig och examinator på följande kurser:

Organisk kemi A 7,5 hp (1KE010)
Galenisk fysikalisk farmaci 7,5 hp (1FA002)
Fysikalisk kemi med livsmedelskemisk inriktning 7,5 hp (1KE018).

Utöver dessa grundutbildningskurser har jag även ansvar för kurser på avancerad nivå och forskarnivå:

Naturvetenskaplig forskningsmetodik 15 hp (4XN002/4XN502) är en kurs på mastersnivå och för doktorander där jag är delkursansvarig för Labbsäkerhet 3 hp
Modern kemi och dess tillämpningar 15 hp (4KE003/4KE503) är en masterskurs där jag har delkursansvar för modulerna Datorbaserad kemi 3 hp, Molekylspektroskopi 3 hp samt Analytisk kemi med inriktning på biosensorer 3 hp.

Sedan 2018 är jag även ledamot i kursplansutskottet på fakulteten för hälsa- och livsvetenskaper (FHL-KUS).

Forskning

Jag har tidigare erfarenhet av biofysikaliska studier av läkemedelsmolekyler, proteiner samt syntetiska polymerer med fokus att utveckla nya sensormaterial och diagnostiska metoder.

I min pågående forskning är jag intresserad av att i detalj förstå de mekanismer som styr sjukdomsutvecklingen hos neurodegenerativa sjukdomar som t.ex. Parkinsons sjukdom (PD). Ett speciellt fokus är att kunna identiera och isolera de tidiga, lösliga, aggregat av protein som är förstadium till de "plack" som man vanligtvis hittar i hjärnan hos patienter som lider av PD och som leder till nervcellsdöd. En intressant hypotes vi arbetar efter är att det finns en aggregad proteinstruktur som har en tredimensionell struktur som är gemensam hos fler neurodegenerativa sjukdomar. Ett mål med den bedrivna forskningen är att försöka hitta denna gemensamma struktur. Framsteg på dessa fronter kommer hjälpa oss att utveckla nya sensorbaserade metoder för diagnostik men även terapeutiska metoder för att bekämpa dessa sjukdomar.

Besök hemsidan för Laboratoriet för fysikalisk farmaci (PPL); se nedan, för mer information om vår forskning.

Mina forskargrupper

Publikationer

Artikel i tidskrift (Refereegranskat)

Näsström, T., Dahlberg, T., Malyshev, D., Ådén, J., Andersson, P., et al. (2021). Synthetic NAC 71-82 Peptides Designed to Produce Fibrils with Different Protofilament Interface Contacts. International Journal of Molecular Sciences. 22 (17).
Status: Publicerad
Näsström, T., Ådén, J., Shibata, F., Andersson, P., Karlsson, B.C.G. (2020). A Capped Peptide of the Aggregation Prone NAC 71–82 Amino Acid Stretch of α-Synuclein Folds into Soluble β-Sheet Oligomers at Low and Elevated Peptide Concentrations. International Journal of Molecular Sciences. 21 (5). 1-14.
Status: Publicerad
Steinz, M.M., Persson, M., Aresh, B., Olsson, K., Cheng, A.J., et al. (2019). Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritis. JCI Insight. 4 (9). 1-16.
Status: Publicerad
Näsström, T., Andersson, P., Lejon, C., Karlsson, B.C.G. (2019). Amyloid fibrils prepared using an acetylated and methyl amidated peptide model of the alpha-Synuclein NAC 71-82 amino acid stretch contain an additional cross-beta structure also found in prion proteins. Scientific Reports. 9. 1-14.
Status: Publicerad
Karlsson, B.C.G., Friedman, R. (2017). Dilution of whisky - the molecular perspective. Scientific Reports. 7 (6489).
Status: Publicerad
Samyn, D.R., Van Der Veken, J., Van Zeebroeck, G., Persson, B.L., Karlsson, B.C.G. (2016). Key Residues and Phosphate Release Routes in the Saccharomyces cerevisae Pho84 Transceptor - The Role of Tyr¹⁷⁹ in Functional Regulation. Journal of Biological Chemistry. 291 (51). 26388-26398.
Status: Publicerad
Shoravi, S., Olsson, G.D., Karlsson, B.C.G., Bexborn, F., Abghoui, Y., et al. (2016). In silico screening of molecular imprinting prepolymerization systems : oseltamivir selective polymers through full-system molecular dynamics-based studies. Organic and biomolecular chemistry. 14 (18). 4210-4219.
Status: Publicerad
Olsson, G.D., Niedergall, K., Bach, M., Karlsson, B.C.G., Tovar, G., et al. (2015). Simulation of imprinted emulsion prepolymerization mixtures. Polymer journal. 47 (12). 827-830.
Status: Publicerad
Nicholls, I.A., Chavan, S., Golker, K., Karlsson, B.C.G., Olsson, G.D., et al. (2015). Theoretical and Computational Strategies for the Study of the Molecular Imprinting Process and Polymer Performance. Advances in Biochemical Engineering, Biotechnology. 150. 25-50.
Status: Publicerad
Golker, K., Karlsson, B.C.G., Wiklander, J.G., Rosengren, A.M., Nicholls, I.A. (2015). Hydrogen bond diversity in the pre-polymerization stage contributes to morphology and MIP-template recognition–MAA versus MMA. European Polymer Journal. 66. 558-568.
Status: Publicerad
Shoravi, S., Olsson, G.D., Karlsson, B.C.G., Nicholls, I.A. (2014). On the Influence of Crosslinker on Template Complexation in Molecularly Imprinted Polymers : A Computational Study of Prepolymerization Mixture Events with Correlations to Template-Polymer Recognition Behavior and NMR Spectroscopic Studies. International Journal of Molecular Sciences. 15 (6). 10622-10634.
Status: Publicerad
Chavan, S., Nicholls, I.A., Karlsson, B.C.G., Rosengren, A.M., Ballabio, D., et al. (2014). Towards Global QSAR Model Building for Acute Toxicity : Munro Database Case Study. International Journal of Molecular Sciences. 15 (10). 18162-18174.
Status: Publicerad
Golker, K., Karlsson, B.C.G., Rosengren, A.M., Nicholls, I.A. (2014). A Functional Monomer Is Not Enough : Principal Component Analysis of the Influence of Template Complexation in Pre-Polymerization Mixtures on Imprinted Polymer Recognition and Morphology. International Journal of Molecular Sciences. 15 (11). 20572-20584.
Status: Publicerad
Cleland, D., Olsson, G.D., Karlsson, B.C.G., Nicholls, I.A., Mccluskey, A. (2014). Molecular dynamics approaches to the design and synthesis of PCB targeting molecularly imprinted polymers: interference to monomer-template interactions in imprinting of 1,2,3-trichlorobenzene. Organic and biomolecular chemistry. 12 (5). 844-853.
Status: Publicerad
Nicholls, I.A., Karlsson, B.C.G., Olsson, G.D., Rosengren, A.M. (2013). Computational Strategies for the Design and Study of Molecularly Imprinted Materials. Industrial & Engineering Chemistry Research. 52 (39). 13900-13909.
Status: Publicerad
Karlsson, B.C.G., Olsson, G.D., Friedman, R., Rosengren, A.M., Henschel, H., et al. (2013). How warfarin’s structural diversity influences its phospholipid bilayer membrane permeation. Journal of Physical Chemistry B. 117 (8). 2384-2395.
Status: Publicerad
Rosengren, A.M., Karlsson, B.C.G., Nicholls, I.A. (2013). Consequences of morphology on molecularly imprinted polymer-ligand recognition. International Journal of Molecular Sciences. 14 (1). 1207-1217.
Status: Publicerad
Golker, K., Karlsson, B.C.G., Olsson, G.D., Rosengren, A.M., Nicholls, I.A. (2013). Influence of composition and morphology on template recognition in molecularly imprinted polymers. Macromolecules. 46 (4). 1408-1414.
Status: Publicerad
Olsson, G.D., Karlsson, B.C.G., Schillinger, E., Sellergren, B., Nicholls, I.A. (2013). Theoretical Studies of 17-beta-Estradiol-Imprinted Prepolymerization Mixtures : Insights Concerning the Roles of Cross-Linking and Functional Monomers in Template Complexation and Polymerization. Industrial & Engineering Chemistry Research. 52 (39). 13965-13970.
Status: Publicerad
Rosengren, A.M., Karlsson, B.C.G., Nicholls, I.A. (2012). Monitoring of the distribution of warfarin in blood plasma. ACS Medicinal Chemistry Letters. 3 (8). 650-652.
Status: Publicerad
Olsson, G.D., Karlsson, B.C.G., Shoravi, S., Wiklander, J.G., Nicholls, I.A. (2012). Mechanisms Underlying Molecularly Imprinted Polymer Molecular Memory and The Role of Crosslinker: Resolving Debate on the Nature of Template Recognition in Phenylalanine Anilide Imprinted Polymers. Journal of Molecular Recognition. 25 (2). 69-73.
Status: Publicerad
Rosengren, A.M., Karlsson, B.C.G., Näslund, I., Andersson, P.O., Nicholls, I.A. (2011). In situ detection of warfarin using time-correlated single-photon counting.. Biochemical and Biophysical Research Communications - BBRC. 407 (1). 60-62.
Status: Publicerad
Rosengren, A.M., Karlsson, B.C.G. (2011). Spectroscopic evidence for the presence of the cyclic hemiketal form of warfarinin aqueous solution: Consequences for bioavailability. Biochemical and Biophysical Research Communications - BBRC. 407 (2). 318-320.
Status: Publicerad
Wiklander, J.G., Karlsson, B.C.G., Aastrup, T., Nicholls, I.A. (2011). Towards a synthetic avidin mimic. Analytical and Bioanalytical Chemistry. 400 (5). 1397-1404.
Status: Publicerad
Karlsson, B.C.G., Rosengren, A.M., Näslund, I., Andersson, P.O., Nicholls, I.A. (2010). Synthetic Human Serum Albumin Sudlow I Binding Site Mimics. Journal of Medicinal Chemistry. 53 (22). 7932-7937.
Status: Publicerad
Nicholls, I.A., Karlsson, B.C.G., Rosengren, A.M., Henschel, H. (2010). Warfarin: an environment-dependent switchable molecular probe. Journal of Molecular Recognition. 23 (6). 604-608.
Status: Publicerad
Henschel, H., Karlsson, B.C.G., Rosengren, A.M., Nicholls, I.A. (2010). The Mechanistic Basis for Warfarin’s Structural Diversity and Implications for Its Bioavailability. Journal of Molecular Structure : THEOCHEM. 958. 7-9.
Status: Publicerad
Nicholls, I.A., Andersson, H.S., Charlton, C., Henschel, H., Karlsson, B.C.G., et al. (2009). Theoretical and Computational Strategies for Rational Molecularly Imprinted Polymer Design. Biosensors & bioelectronics. 25 (3). 543-552.
Status: Publicerad
Karlsson, B.C.G., O'mahony, J., Karlsson, J.G., Bengtsson, H., Eriksson, L.A., et al. (2009). Structure and Dynamics of Monomer-Template Complexation: An Explanation for Molecularly Imprinted Polymer Recognition Site Heterogeneity. Journal of the American Chemical Society. 131 (37). 13297-13304.
Status: Publicerad
Karlsson, B.C.G., Rosengren, A.M., Andersson, P., Nicholls, I.A. (2009). Molecular Insights on the Two Fluorescence Lifetimes Displayed by Warfarin from Fluorescence Anisotropy and Molecular Dynamics Studies. Journal of Physical Chemistry B. 113 (22). 7945-7949.
Status: Publicerad
O'mahony, J., Karlsson, B.C.G., Mizaikoff, B., Nicholls, I.A. (2007). Correlated theoretical, spectroscopic and X-ray crystallographic studies of a non-covalent molecularly imprinted polymerisation system. The Analyst. 132. 1161-1168.
Status: Publicerad
Karlsson, B.C.G., Rosengren, A.M., Andersson, P., Nicholls, I.A. (2007). The Spectrophysics of Warfarin: Implications for Protein Binding. Journal of Physical Chemistry B. 111. 10520-10528.
Status: Publicerad
Karlsson, J.G., Karlsson, B.C.G., Andersson, L.I., Nicholls, I.A. (2004). The roles of template complexation and ligand binding conditions on recognition in bupivacaine molecularly imprinted polymers. Analyst. 129 (5). 456-462.
Status: Publicerad

Konferensbidrag (Refereegranskat)

Nicholls, I.A., Shoravi, S., Orozovic, K., Olsson, G.D., Karlsson, B.C.G. (2011). Synthetic Neuraminidases : Nanostructured Materials for Environmental Monitoring. Ecohealth, vol. 7, Supplement 1. S97-S97.
Karlsson, B.C.G., Rosengren, A.M., Näslund, I., Andersson, P.O., Nicholls, I.A. (2010). A molecularly imprinted polymer-based detection of Warfarin using time resolved fluorescence spectroscopy. .
Rosengren, A.M., Karlsson, B.C.G., Nicholls, I.A. (2010). Morphology studies on warfarin imprinted polymers: the significance of the degree of crosslinking on polymer performance. .
Golker, K., Karlsson, B.C.G., Olsson, G.D., Nicholls, I.A. (2010). Towards Molecular Dynamics-Based Rational Design of Synthetic Polymer Recognition Systems. .
Golker, K., Karlsson, B.C.G., Olsson, G.D., Nicholls, I.A. (2010). Towards the use of molecular dynamics as a predictive tool in the design of molecularly imprinted polymers. .
Olsson, G.D., Karlsson, B.C.G., Wiklander, J.G., Nicholls, I.A. (2010). Mechanism of Phenylalanine Anilide Molecularly Imprinted Polymer - Template Recognition: The Role of Template Dimerization. .
Olsson, G.D., Karlsson, B.C.G., Wiklander, J.G., Shoravi, S., Nicholls, I.A. (2010). The nature and extent of interactions in phenylalanine anilide molecularly imprinted polymer prepolymerisation mixtures: a new model for the basis for ligand-selective recognition. .
Shoravi, S., Orozovic, K., Karlsson, B.C.G., Wiklander, J.G., Nicholls, I.A. (2010). Towards Synthetic Neuraminidases. .
Olsson, G.D., Karlsson, B.C.G., Wiklander, J.G., Shoravi, S., Nicholls, I.A. (2010). The Nature and Extent of Template-Template Complexation in Phenylalanine Anilide Molecularly Imprinted Polymers. .
Golker, K., Karlsson, B.C.G., Olsson, G.D., Nicholls, I.A. (2010). Towards Molecular Dynamics-Based Rational Design of Polymeric Recognition Systems. .
Wiklander, J.G., Karlsson, B.C.G., Aastrup, T., Nicholls, I.A. (2010). A synthetic polymer with avidin-like binding properties. .
Henschel, H., Karlsson, B.C.G., Rosengren, A.M., Nicholls, I.A. (2010). Insights into the Isomerisation Mechanism of Warfarin. .
Shoravi, S., Karlsson, B.C.G., Olsson, G.D., Nicholls, I.A. (2010). Molecular dynamics study of mechanisms underlying propranolol-mip molecular memory and the role of cross-linker. .
Karlsson, B.C.G., Olsson, G.D., Rosengren, A.M., Nicholls, I.A. (2010). The Effect of Warfarin’s Structural Diversity on Permeation Across a DPPC Bilayer Membrane. .
Rosengren, A.M., Karlsson, B.C.G., Näslund, I., Andersson, P.O., Nicholls, I.A. (2010). Time Resolved Fluorescence Spectroscopic Detection of the Anticoagulant Warfarin: A Sensor-based Method for Direct Detection in Blood-plasma. .
Nicholls, I.A., Karlsson, B.C.G., Andersson, H.S., Golker, K., Henschel, H., et al. (2009). Biomimetic Polymer Design. .
Karlsson, B.C.G., Rosengren, A.M., Andersson, P., Nicholls, I.A. (2009). The spectrophysics of warfarin: Implications for protein binding. .
Karlsson, B.C.G., O'mahony, J., Karlsson, J.G., Bengtsson, H., Eriksson, L.A., et al. (2009). Structure and dynamics of monomer-template complexation: can molecularly imprinted polymer recognition site heterogeneity be explained?. .
Karlsson, B.C.G., Rosengren, A.M., Andersson, P.O., Nicholls, I.A. (2009). The Spectrophysics of Warfarin. .
Karlsson, B., Rosengren, A., Andersson, P., Nicholls, I.A. (2006). The role of isomerization on the spectroscopic properties of Warfarin. .
Karlsson, B., Rosengren, A., Andersson, P., Nicholls, I.A. (2006). The role of isomerization on the spectroscopic properties of Warfarin. .
O'mahony, J., Karlsson, B., Mizaikoff, B., Nicholls, I.A. (2006). Prior to polymerisation: Insights from correlated theoretical, solution phase and solid state studies. .
O'mahony, J., Karlsson, B., Nicholls, I.A. (2006). Structure and dynamics of template-monomer complexation: An explanation for recognition site heterogeneity. .
Karlsson, J.G., Karlsson, B., Andersson, L.I., Nicholls, I.A. (2004). The roles of template complexation and ligand binding conditions on recognition in bupivacaine molecularly imprinted polymers. .

Kapitel i bok, del av antologi (Refereegranskat)

Nicholls, I.A., Olsson, G.D., Karlsson, B.C.G., Suriyanarayanan, S., Wiklander, J.G. (2018). Theoretical and Computational Strategies in Molecularly Imprinted Polymer Development. Molecularly Imprinted Polymers for Analytical Chemistry Applications. London, Royal Society of Chemistry. 197-226.
Nicholls, I.A., Andersson, H.S., Golker, K., Henschel, H., Karlsson, B.C.G., et al. (2013). Rational molecularly imprinted polymer design : theoretical and computational strategies. Molecular Imprinting : Principles and Applications of Micro- and Nanostructured Polymers. London, Pan Stanford Publishing. 71-104.

Artikel, forskningsöversikt (Refereegranskat)

Nicholls, I.A., Andersson, H.S., Golker, K., Henschel, H., Karlsson, B.C.G., et al. (2011). Rational Design of Biomimetic Molecularly Imprinted Materials: Theoretical and Computational Strategies for Guiding Nanoscale Structured Polymer Development. Analytical and Bioanalytical Chemistry. 400. 1771-1786.
Status: Publicerad

Konferensbidrag (Övrigt vetenskapligt)

Karlsson, B., O'mahony, J., Karlsson, J.G., Bengtsson, H., Eriksson, L.A., et al. (2008). Structure and dynamics of monomer-template complexation: an explanation for molecularly imprinted polymer recognition site heterogeneity. .

Kapitel i bok, del av antologi (Övrigt vetenskapligt)

Karlsson, B.C.G. (2013). Molekylmodellering. En litteraturstudie över dess användning i högre kemiutbildning. Universitetspedagogik i praktiken : Sexton lärartexter om pedagogisk utveckling. Växjö, Linnaeus University. 161-173.

Patent (Övrigt (populärvetenskap, debatt))

Nicholls, I.A., Karlsson, B.C.G., Rosengren, A.M., Andersson, P. (2014). Method and apparatus for detecting pharmaceuticals in a sample.
Nicholls, I.A., Andersson, P., Karlsson, B.C.G., Rosengren, A.M. (2010). Method and apparatus for detecting pharmaceuticals in a sample.
Nicholls, I.A., Andersson, P., Karlsson, B.C.G., Rosengren, A.M. (2009). Method and apparatus for detecting pharmaceuticals in a sample.

Björn Karlsson

Undervisning

Forskning

Mina forskargrupper

Publikationer

Artikel i tid­skrift (Referee­granskat)

Konferens­bidrag (Referee­granskat)

Kapitel i bok, del av antologi (Referee­granskat)

Artikel, forsknings­översikt (Referee­granskat)

Konferens­bidrag (Övrigt veten­skapligt)

Kapitel i bok, del av antologi (Övrigt veten­skapligt)

Patent (Övrigt (populär­vetenskap, debatt))