Björn Karlsson

Hej!
Jag heter Björn C.G. Karlsson och är anställd som universitetslektor i fysikalisk kemi med galenisk farmaci vid Linnéuniversitetet. Sedan 2013 är jag även docent i fysikalisk kemi.

Undervisning

Jag är idag kursansvarig samt examinator på kurserna i Organisk kemi 7,5 hp (1KE010), Galenisk fysikalisk farmaci 7,5 hp (1FA002) samt Fysikalisk kemi 7,5 hp (1KE002). Förutom dessa grundutbildningskurser så är jag även delkursansvarig för Naturvetenskaplig forskningsmetodik 15 hp (4XN002), en kurs på avancerad nivå för doktorander samt studenter på Mastersnivå. Inom en annan kurs på avancerad nivå, Modern kemi och dess tillämpningar 15 hp (4KE003) har jag delkursansvar för kurser i Datorbaserad kemi 3 hp, Molekylspektroskopi 3 hp samt Analytisk kemi med inriktning på biosensorer 3 hp.

Forskning

Min bakgrund är inom det bioorganiska och biofysikaliska forskningsområdet där jag har stor erfarenhet av studier av fysikaliska studier av olika läkemedelsmolekyler samt polymermaterial. Dessa har mestadels studerats med hjälp av en rad teoretiska metoder såsom kvantmekaniska ab initio-beräkningar samt klassisk-mekaniska molekyldynamik simuleringar. Experimentella studier har huvudsakligen omfattat polymersyntes samt molekylspektroskopiska metoder såsom NMR-, FT-IR-, UV/Vis-absorption- samt fluorescensspektroskopi (steady-state samt tidsupplösta tekniker).

I min pågående forskning är jag intresserad av att i detalj förstå de mekaniskmer som styr I) sjukdomsutvecklingen hos Parkinsons sjukdom, ett projekt som görs i nära samarbete med Med Dr Thomas Näsström och där vi tillsammans försöker kartlägga viktiga pusselbitar som ger svar på frågan varför en nerv-cell dör samt hur en sjuk cell kan smitta en annan frisk cell? II) Ett annat projekt är ett viktigt fokus är att förstå de mekanismer som ligger till grund för den selektivitet som uppvisas av de membranproteiner som tillhör gruppen 'Major Facilitator Superfamily' (MFS) och som sköter den mycket viktiga regleringen av viktiga näringsämnen in och ut ur våra celler. Detta är ett projekt som görs i nära samarbete med Professor Bengt Persson samt Dr Dieter Samyn och som initialt har fokuserat på proteinet Pho84s reglering av fosfat hos Saccharomyces cerevisiae.

Slutligen har jag i min forskning III) även ett grundläggande intresse av studier som omfattar grundläggande fysikalisk-kemiska frågeställningar. Exempelvis bedrivs pågående forskning t.ex. om hur molekylstrukturen hos organiska föreningar påverkar deras löslighet samt förångning från icke-ideala blandningar, egenskaper som har konsekvenser vid läkemedelsutveckling samt beredning.

För att läsa mer om min forskning, besök Laboratoriet för fysikalisk farmaci (PPL); se nedan.

Mina forskargrupper

Publikationer

Artikel i tidskrift (Refereegranskat)

Steinz, M.M., Persson, M., Aresh, B., Olsson, K., Cheng, A.J., et al. (2019). Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritis. JCI Insight. 4. 1-16.
Näsström, T., Andersson, P.O., Lejon, C., Karlsson, B.C.G. (2019). Amyloid fibrils prepared using an acetylated and methyl amidated peptide model of the alpha-Synuclein NAC 71-82 amino acid stretch contain an additional cross-beta structure also found in prion proteins. Scientific Reports. 9. 1-14.
Karlsson, B.C.G., Friedman, R. (2017). Dilution of whisky - the molecular perspective. Scientific Reports. 7.
Shoravi, S., Olsson, G.D., Karlsson, B.C.G., Bexborn, F., Abghoui, Y., et al. (2016). In silico screening of molecular imprinting prepolymerization systems : oseltamivir selective polymers through full-system molecular dynamics-based studies. Organic and biomolecular chemistry. 14. 4210-4219.
Samyn, D.R., van Der Veken, J., van Zeebroeck, G., Persson, B.L., Karlsson, B.C.G. (2016). Key Residues and Phosphate Release Routes in the Saccharomyces cerevisae Pho84 Transceptor - The Role of Tyr¹⁷⁹ in Functional Regulation. Journal of Biological Chemistry. 291. 26388-26398.
Olsson, G.D., Niedergall, K., Bach, M., Karlsson, B.C.G., Tovar, G., et al. (2015). Simulation of imprinted emulsion prepolymerization mixtures. Polymer journal. 47. 827-830.
Golker, K., Karlsson, B.C.G., Wiklander, J.G., Rosengren, A.M., Nicholls, I.A. (2015). Hydrogen bond diversity in the pre-polymerization stage contributes to morphology and MIP-template recognition–MAA versus MMA. European Polymer Journal. 66. 558-568.
Shoravi, S., Olsson, G.D., Karlsson, B.C.G., Nicholls, I.A. (2014). On the Influence of Crosslinker on Template Complexation in Molecularly Imprinted Polymers : A Computational Study of Prepolymerization Mixture Events with Correlations to Template-Polymer Recognition Behavior and NMR Spectroscopic Studies. International Journal of Molecular Sciences. 15. 10622-10634.
Chavan, S., Nicholls, I.A., Karlsson, B.C.G., Rosengren, A.M., Ballabio, D., et al. (2014). Towards Global QSAR Model Building for Acute Toxicity : Munro Database Case Study. International Journal of Molecular Sciences. 15. 18162-18174.
Golker, K., Karlsson, B.C.G., Rosengren, A.M., Nicholls, I.A. (2014). A Functional Monomer Is Not Enough : Principal Component Analysis of the Influence of Template Complexation in Pre-Polymerization Mixtures on Imprinted Polymer Recognition and Morphology. International Journal of Molecular Sciences. 15. 20572-20584.
Cleland, D., Olsson, G.D., Karlsson, B.C.G., Nicholls, I.A., Mccluskey, A. (2014). Molecular dynamics approaches to the design and synthesis of PCB targeting molecularly imprinted polymers: interference to monomer-template interactions in imprinting of 1,2,3-trichlorobenzene. Organic and biomolecular chemistry. 12. 844-853.
Nicholls, I.A., Karlsson, B.C.G., Olsson, G.D., Rosengren, A.M. (2013). Computational Strategies for the Design and Study of Molecularly Imprinted Materials. Industrial & Engineering Chemistry Research. 52. 13900-13909.
Karlsson, B.C.G., Olsson, G.D., Friedman, R., Rosengren, A.M., Henschel, H., et al. (2013). How warfarin’s structural diversity influences its phospholipid bilayer membrane permeation. Journal of Physical Chemistry B. 117. 2384-2395.
Rosengren, A.M., Karlsson, B.C.G., Nicholls, I.A. (2013). Consequences of morphology on molecularly imprinted polymer-ligand recognition. International Journal of Molecular Sciences. 14. 1207-1217.
Golker, K., Karlsson, B.C.G., Olsson, G.D., Rosengren, A.M., Nicholls, I.A. (2013). Influence of composition and morphology on template recognition in molecularly imprinted polymers. Macromolecules. 46. 1408-1414.
Olsson, G.D., Karlsson, B.C.G., Schillinger, E., Sellergren, B., Nicholls, I.A. (2013). Theoretical Studies of 17-beta-Estradiol-Imprinted Prepolymerization Mixtures : Insights Concerning the Roles of Cross-Linking and Functional Monomers in Template Complexation and Polymerization. Industrial & Engineering Chemistry Research. 52. 13965-13970.
Olsson, G.D., Karlsson, B.C.G., Shoravi, S., Wiklander, J.G., Nicholls, I.A. (2012). Mechanisms Underlying Molecularly Imprinted Polymer Molecular Memory and The Role of Crosslinker: Resolving Debate on the Nature of Template Recognition in Phenylalanine Anilide Imprinted Polymers. Journal of Molecular Recognition. 25. 69-73.
Rosengren, A.M., Karlsson, B.C.G., Nicholls, I.A. (2012). Monitoring of the distribution of warfarin in blood plasma. ACS Medicinal Chemistry Letters. 3. 650-652.
Rosengren, A.M., Karlsson, B.C.G., Näslund, I., Andersson, P.O., Nicholls, I.A. (2011). In situ detection of warfarin using time-correlated single-photon counting.. Biochemical and Biophysical Research Communications - BBRC. 407. 60-62.
Rosengren, A.M., Karlsson, B.C.G. (2011). Spectroscopic evidence for the presence of the cyclic hemiketal form of warfarinin aqueous solution: Consequences for bioavailability. Biochemical and Biophysical Research Communications - BBRC. 407. 318-320.
Wiklander, J.G., Karlsson, B.C.G., Aastrup, T., Nicholls, I.A. (2011). Towards a synthetic avidin mimic. Analytical and Bioanalytical Chemistry. 400. 1397-1404.
Karlsson, B.C.G., Rosengren, A.M., Näslund, I., Andersson, P.O., Nicholls, I.A. (2010). Synthetic Human Serum Albumin Sudlow I Binding Site Mimics. Journal of Medicinal Chemistry. 53. 7932-7937.
Nicholls, I.A., Karlsson, B.C.G., Rosengren, A.M., Henschel, H. (2010). Warfarin: an environment-dependent switchable molecular probe. Journal of Molecular Recognition. 23. 604-608.
Henschel, H., Karlsson, B.C.G., Rosengren, A.M., Nicholls, I.A. (2010). The Mechanistic Basis for Warfarin’s Structural Diversity and Implications for Its Bioavailability. Journal of Molecular Structure : THEOCHEM. 958. 7-9.
Nicholls, I.A., Andersson, H.S., Charlton, C., Henschel, H., Karlsson, B.C.G., et al. (2009). Theoretical and Computational Strategies for Rational Molecularly Imprinted Polymer Design. Biosensors & bioelectronics. 25. 543-552.
Karlsson, B.C.G., O'mahony, J., Karlsson, J.G., Bengtsson, H., Eriksson, L.A., et al. (2009). Structure and Dynamics of Monomer-Template Complexation: An Explanation for Molecularly Imprinted Polymer Recognition Site Heterogeneity. Journal of the American Chemical Society. 131. 13297-13304.
Karlsson, B.C.G., Rosengren, A.M., Andersson, P., Nicholls, I.A. (2009). Molecular Insights on the Two Fluorescence Lifetimes Displayed by Warfarin from Fluorescence Anisotropy and Molecular Dynamics Studies. Journal of Physical Chemistry B. 113. 7945-7949.
O'mahony, J., Karlsson, B.C.G., Mizaikoff, B., Nicholls, I.A. (2007). Correlated theoretical, spectroscopic and X-ray crystallographic studies of a non-covalent molecularly imprinted polymerisation system. The Analyst. 132. 1161-1168.
Karlsson, B.C.G., Rosengren, A.M., Andersson, P., Nicholls, I.A. (2007). The Spectrophysics of Warfarin: Implications for Protein Binding. Journal of Physical Chemistry B. 111. 10520-10528.
Karlsson, J.G., Karlsson, B.C.G., Andersson, L.I., Nicholls, I.A. (2004). The roles of template complexation and ligand binding conditions on recognition in bupivacaine molecularly imprinted polymers. Analyst. 129. 456-462.

Konferensbidrag (Refereegranskat)

Nicholls, I.A., Shoravi, S., Orozovic, K., Olsson, G.D., Karlsson, B.C.G. (2011). Synthetic Neuraminidases : Nanostructured Materials for Environmental Monitoring. Ecohealth, vol. 7, Supplement 1. S97-S97.
Karlsson, B.C.G., Rosengren, A.M., Näslund, I., Andersson, P.O., Nicholls, I.A. (2010). A molecularly imprinted polymer-based detection of Warfarin using time resolved fluorescence spectroscopy. .
Olsson, G.D., Karlsson, B.C.G., Wiklander, J.G., Nicholls, I.A. (2010). Mechanism of Phenylalanine Anilide Molecularly Imprinted Polymer - Template Recognition: The Role of Template Dimerization. .
Rosengren, A.M., Karlsson, B.C.G., Nicholls, I.A. (2010). Morphology studies on warfarin imprinted polymers: the significance of the degree of crosslinking on polymer performance. .
Olsson, G.D., Karlsson, B.C.G., Wiklander, J.G., Shoravi, S., Nicholls, I.A. (2010). The nature and extent of interactions in phenylalanine anilide molecularly imprinted polymer prepolymerisation mixtures: a new model for the basis for ligand-selective recognition. .
Golker, K., Karlsson, B.C.G., Olsson, G.D., Nicholls, I.A. (2010). Towards Molecular Dynamics-Based Rational Design of Synthetic Polymer Recognition Systems. .
Shoravi, S., Orozovic, K., Karlsson, B.C.G., Wiklander, J.G., Nicholls, I.A. (2010). Towards Synthetic Neuraminidases. .
Golker, K., Karlsson, B.C.G., Olsson, G.D., Nicholls, I.A. (2010). Towards the use of molecular dynamics as a predictive tool in the design of molecularly imprinted polymers. .
Olsson, G.D., Karlsson, B.C.G., Wiklander, J.G., Shoravi, S., Nicholls, I.A. (2010). The Nature and Extent of Template-Template Complexation in Phenylalanine Anilide Molecularly Imprinted Polymers. .
Golker, K., Karlsson, B.C.G., Olsson, G.D., Nicholls, I.A. (2010). Towards Molecular Dynamics-Based Rational Design of Polymeric Recognition Systems. .
Wiklander, J.G., Karlsson, B.C.G., Aastrup, T., Nicholls, I.A. (2010). A synthetic polymer with avidin-like binding properties. .
Henschel, H., Karlsson, B.C.G., Rosengren, A.M., Nicholls, I.A. (2010). Insights into the Isomerisation Mechanism of Warfarin. .
Shoravi, S., Karlsson, B.C.G., Olsson, G.D., Nicholls, I.A. (2010). Molecular dynamics study of mechanisms underlying propranolol-mip molecular memory and the role of cross-linker. .
Karlsson, B.C.G., Olsson, G.D., Rosengren, A.M., Nicholls, I.A. (2010). The Effect of Warfarin’s Structural Diversity on Permeation Across a DPPC Bilayer Membrane. .
Rosengren, A.M., Karlsson, B.C.G., Näslund, I., Andersson, P.O., Nicholls, I.A. (2010). Time Resolved Fluorescence Spectroscopic Detection of the Anticoagulant Warfarin: A Sensor-based Method for Direct Detection in Blood-plasma. .
Karlsson, B.C.G., Rosengren, A.M., Andersson, P., Nicholls, I.A. (2009). The spectrophysics of warfarin: Implications for protein binding. .
Nicholls, I.A., Karlsson, B.C.G., Andersson, H.S., Golker, K., Henschel, H., et al. (2009). Biomimetic Polymer Design. .
Karlsson, B.C.G., O'mahony, J., Karlsson, J.G., Bengtsson, H., Eriksson, L.A., et al. (2009). Structure and dynamics of monomer-template complexation: can molecularly imprinted polymer recognition site heterogeneity be explained?. .
Karlsson, B.C.G., Rosengren, A.M., Andersson, P.O., Nicholls, I.A. (2009). The Spectrophysics of Warfarin. .
Karlsson, B., Rosengren, A., Andersson, P., Nicholls, I.A. (2006). The role of isomerization on the spectroscopic properties of Warfarin. .
Karlsson, B., Rosengren, A., Andersson, P., Nicholls, I.A. (2006). The role of isomerization on the spectroscopic properties of Warfarin. .
O'mahony, J., Karlsson, B., Mizaikoff, B., Nicholls, I.A. (2006). Prior to polymerisation: Insights from correlated theoretical, solution phase and solid state studies. .
O'mahony, J., Karlsson, B., Nicholls, I.A. (2006). Structure and dynamics of template-monomer complexation: An explanation for recognition site heterogeneity. .
Karlsson, J.G., Karlsson, B., Andersson, L.I., Nicholls, I.A. (2004). The roles of template complexation and ligand binding conditions on recognition in bupivacaine molecularly imprinted polymers. .

Kapitel i bok, del av antologi (Refereegranskat)

Nicholls, I.A., Olsson, G.D., Karlsson, B.C.G., Suriyanarayanan, S., Wiklander, J.G. (2018). Theoretical and Computational Strategies in Molecularly Imprinted Polymer Development. Molecularly Imprinted Polymers for Analytical Chemistry Applications. London, Royal Society of Chemistry. 197-226.
Nicholls, I.A., Chavan, S., Golker, K., Karlsson, B.C.G., Olsson, G.D., et al. (2015). Theoretical and Computational Strategies for the Study of the Molecular Imprinting Process and Polymer Performance. Molecularly Imprinted Polymers in Biotechnology. Berlin, Springer. 25-50.
Nicholls, I.A., Andersson, H.S., Golker, K., Henschel, H., Karlsson, B.C.G., et al. (2013). Rational molecularly imprinted polymer design : theoretical and computational strategies. Molecular Imprinting : Principles and Applications of Micro- and Nanostructured Polymers. London, Pan Stanford Publishing. 71-104.

Artikel, forskningöversikt (Refereegranskat)

Nicholls, I.A., Andersson, H.S., Golker, K., Henschel, H., Karlsson, B.C.G., et al. (2011). Rational Design of Biomimetic Molecularly Imprinted Materials: Theoretical and Computational Strategies for Guiding Nanoscale Structured Polymer Development. Analytical and Bioanalytical Chemistry. 400. 1771-1786.

Konferensbidrag (Övrigt vetenskapligt)

Karlsson, B., O'mahony, J., Karlsson, J.G., Bengtsson, H., Eriksson, L.A., et al. (2008). Structure and dynamics of monomer-template complexation: an explanation for molecularly imprinted polymer recognition site heterogeneity. .

Kapitel i bok, del av antologi (Övrigt vetenskapligt)

Karlsson, B.C.G. (2013). Molekylmodellering. En litteraturstudie över dess användning i högre kemiutbildning. Universitetspedagogik i praktiken : Sexton lärartexter om pedagogisk utveckling. Växjö, Linnaeus University. 161-173.

Patent (Övrigt (populärvetenskap, debatt))

Nicholls, I.A., Karlsson, B.C.G., Rosengren, A.M., Andersson, P. (2014). Method and apparatus for detecting pharmaceuticals in a sample.
Nicholls, I.A., Andersson, P., Karlsson, B.C.G., Rosengren, A.M. (2010). Method and apparatus for detecting pharmaceuticals in a sample.
Nicholls, I.A., Andersson, P., Karlsson, B.C.G., Rosengren, A.M. (2009). Method and apparatus for detecting pharmaceuticals in a sample.

Undervisning

Forskning

Mina forskargrupper

Publikationer

Artikel i tid­skrift (Referee­granskat)

Konferens­bidrag (Referee­granskat)

Kapitel i bok, del av antologi (Referee­granskat)

Artikel, forskning­översikt (Referee­granskat)

Konferens­bidrag (Övrigt veten­skapligt)

Kapitel i bok, del av antologi (Övrigt veten­skapligt)

Patent (Övrigt (populär­vetenskap, debatt))