Cornelia Witthöft

Professor

Institutionen för kemi och biomedicin Fakulteten för hälso- och livsvetenskap

cornelia.witthoft@lnu.se

0480-44 63 10

072-529 58 10

Jag är professor i livsmedelsvetenskap med inriktning på nutrition/livsmedelskemi vid institutionen för kemi och biomedicin. Min forskning handlar om matens kvalitet samt utveckling av nya hälsosamma livsmedel. Därför är jag intresserad av att karakterisera näringsämnen i råvaror och livsmedel och att studera hur livsmedelsprocesser påverkar näringsämnena. Ytterligare fokus ligger på forskning om matens effekt på människans hälsa. Mitt särskilda forskningsintresse under de senaste 25 åren har varit forskning kring vitaminet folat, vilket är ett bristvitamin i många länder.

Undervisning

Jag undervisar studenter inom ämnena livsmedelskunskap, näringslära, livsmedelskemi och livsmedelsanalys i flera av Lnu:s program, t ex kandidatprogrammen "nutrition och livsmedelsvetenskap" eller "hälsovetenskap" samt i en kurs inom entreprenörskap. Jag är också handledare och examinator för examensarbeten.

Forskning

Välbefinnandet och hälsan påverkas av kosten som ska vara hälsosam, mättande och god. Koststudier visar däremot att vår kosthållning är långt ifrån optimal och målet att arbeta mot en förbättring av människors matvanor kräver vetenskapligt underbyggda näringsrekommendationer, kunskap om maten samt ett stort utbud av välsmakande och hälsosamma livsmedel. Genom att karakterisera råvaror och livsmedel samt att undersöka hur traditionell matberedning och industriella tillverkningsprocesser påverkar matens kvalitetsegenskaper och näringsinnehåll, erhåller vi underlag för att kunna utveckla nya hälsosamma livsmedel. Matens effekt på hälsan studeras sedan med hjälp av humanstudier eller in vitro/simulationsmodeller för att få kunskap om näringsämnenas absorption, biotillgänglighet och metabolism. Sedan 25 år tillbaka har jag ett särskilt intresse för vitaminet folat. Livsmedelsprocesser kan påverka folathalten både positivt och negativt, och fortfarande är kunskapen om vitaminets biotillgänglighet och effekt på hälsan begränsad.

Uppdrag

LNU:s vicerektor för forskning (sedan 2021, på 30 %)
Ledamot i Livsmedelsverkets expertgrupp för nutrition och folkhälsa
Nominerad vetenskaplig expert i revideringen av de Nordiska Näringsrekommendationer 2022
Ledamot i styrgruppen för Livsmedelsutveckling Sydost i Kalmar län
Ledamot i styrgruppen för Hushållningssällskapets Utvecklingscentrum vid Torslunda
Lnu:s kontaktperson för livsmedel inom Småland-Blekinge South Sweden

Filmlänkar

Video-sändning från Kalmarsundsveckan 2020 där Cornelia Wiffhöft medverkar. Skrolla ner till "Dåtidens mat – Är dåtidens mat framtidens mat".
Familjen Kamprads seminarieserie för äldre då Cornelia Witthöft föreläser om "Hälsosamma livsmedel från växtriket"
Är ärtsoppa och bruna bönor två traditionella rätter som kan bidra till flera positiva effekter för hälsan? Cornelia Witthöft berättar om sin forskning kring baljväxter (bönor, ärtor, linser) och om fördelarna av att äta en varierad växtberikad kost.

Forskningsområden

Forskningsomraden-inom-livsmedelsvetenskap.pdf

Lyssna på Cornelia i vår podcast

Sköna bönor! En snabbkurs för dig som har en dålig relation med baljväxter PODD: Är du ännu inte helt övertygad om poängen med baljväxter? Lyssna då på denna podd. Vi följer med vår baljväxtexpert…

Film: Groddning - ett smart sätt att få i sig vitaminet folat

Mina forskargrupper

Mina pågående forskningsprojekt

Mina avslutade forskningsprojekt

Publikationer

Artikel i tidskrift (Refereegranskat)

Liu, J., Hefni, M.E., Witthöft, C.M., Bergström, M., Burleigh, S., et al. (2022). On the effect of flavonoids and dietary fibre in lingonberries on atherosclerotic plaques, lipid profiles and gut microbiota composition in Apoe(-/-) mice. International Journal of Food Sciences and Nutrition. 73 (8). 1080-1090.
Status: Publicerad
Liu, J., Hefni, M.E., Witthöft, C.M., Bergström, M., Burleigh, S., et al. (2022). Effects of Whole Brown Bean and Its Isolated Fiber Fraction on Plasma Lipid Profile, Atherosclerosis, Gut Microbiota, and Microbiota-Dependent Metabolites in Apoe−/− Mice. Nutrients. 14 (5).
Status: Publicerad
Ferawati, F., Zahari, I., Barman, M., Hefni, M.E., Ahlström, C., et al. (2021). High-Moisture Meat Analogues Produced from Yellow Pea and Faba Bean Protein Isolates/Concentrate : Effect of Raw Material Composition and Extrusion Parameters on Texture Properties. Foods. 10 (4).
Status: Publicerad
Ferawati, F., Hefni, M.E., Östbring, K., Witthöft, C.M. (2021). The Application of Pulse Flours in the Development of Plant-Based Cheese Analogues : Proximate Composition, Color, and Texture Properties. Foods. 10 (9).
Status: Publicerad
Hefni, M.E., Thomsson, A., Witthöft, C.M. (2021). Bread making with sourdough and intact cereal and legume grains - effect on glycaemic index and glycaemic load. International Journal of Food Sciences and Nutrition. 72 (1). 134-142.
Status: Publicerad
Liu, J., Hefni, M.E., Witthöft, C.M. (2021). Phenolic compounds in Swedish dried pulses : Characterization, retention and distribution during hydrothermal treatment processes. Journal of Food Composition and Analysis. 102.
Status: Publicerad
Hefni, M.E., Bergström, M., Lennqvist, T., Fagerström, C., Witthöft, C.M. (2021). Simultaneous quantification of trimethylamine N-oxide, trimethylamine, choline, betaine, creatinine, and propionyl-, acetyl-, and L-carnitine in clinical and food samples using HILIC-LC-MS. Analytical and Bioanalytical Chemistry. 413. 5349-5360.
Status: Publicerad
Liu, J., Hefni, M.E., Witthöft, C.M. (2020). Characterization of Flavonoid Compounds in Common Swedish Berry Species. Foods. 9 (3). 1-13.
Status: Publicerad
Ferawati, F., Witthöft, C.M., Bergström, M. (2020). Characterization of volatile compounds in Swedish yellow and gray peas : implications for new legume‐based ingredients. Legume Science. 2 (4).
Status: Publicerad
Röös, E., Carlsson, G., Ferawati, F., Hefni, M.E., Stephan, A., et al. (2020). Less meat, more legumes : prospects and challenges in the transition toward sustainable diets in Sweden. Renewable Agriculture and Food Systems. 35 (2). 192-205.
Status: Publicerad
Steib, C.A., Johansson, I., Hefni, M.E., Witthöft, C.M. (2020). Diet and nutrient status of legume consumers in Sweden : a descriptive crosssectional study. Nutrition Journal. 19 (1). 1-10.
Status: Publicerad
Hefni, M.E., Amann, L.S., Witthöft, C.M. (2019). A HPLC-UV Method for the Quantification of Phenolic Acids in Cereals. Food Analytical Methods. 12 (12). 2802-2812.
Status: Publicerad
Östman, J.R., Müllner, E., Eriksson, J., Kristinsson, H., Gustafsson, J., et al. (2019). Glucose Appearance Rate Rather than the Blood Glucose Concentrations Explains Differences in Postprandial Insulin Responses between Wholemeal Rye and Refined Wheat Breads—Results from A Cross-Over Meal Study. Molecular Nutrition & Food Research. 63 (7). 1-9.
Status: Publicerad
Ferawati, F., Hefni, M.E., Witthöft, C.M. (2019). Flours from Swedish pulses : Effects of treatment on functional properties and nutrient content. Food Science & Nutrition. 7 (12). 4116-4126.
Status: Publicerad
Hefni, M.E., Witthöft, C.M., Moazzami, A. (2018). Plasma metabolite profiles in healthy women differ after intervention with supplemental folic acid v. folate-rich foods. Journal of Nutritional Science. 7. 1-9.
Status: Publicerad
Hefni, M.E., Schaller, F., Witthöft, C.M. (2018). Betaine, choline and folate content in different cereal genotypes. Journal of Cereal Science. 80. 72-79.
Status: Publicerad
Sonesson, U., Davis, J., Flysjo, A., Gustaysson, J., Witthöft, C.M. (2017). Protein quality as functional unit : A methodological framework for inclusion in life cycle assessment of food. Journal of Cleaner Production. 140 (Special Issue, Part 2). 470-478.
Status: Publicerad
Nicolas, G., Witthöft, C.M., Vignat, J., Knaze, V., Huybrechts, I., et al. (2016). Compilation of a standardised international folate database for EPIC.. Food Chemistry. 193. 134-140.
Status: Publicerad
Hefni, M.E., Shalaby, M.T., Mohamed, R.A., Elwa, A.M., Witthöft, C.M. (2016). Effect of a 12-Week Dietary Intervention with Folic Acid or Folate-Enhanced Foods on Folate Status in Healthy Egyptian Women. Food and Nutrition Sciences. 7. 1339-1351.
Status: Publicerad
Röös, E., Karlsson, H., Witthöft, C.M., Sundberg, C. (2015). Evaluating the sustainability of diets-combining environmental and nutritional aspects. Environmental Science and Policy. 47. 157-166.
Status: Publicerad
Witthöft, C.M., Hefni, M.E., Moazzami, A. (2015). Folic acid supplement induces changes in 1-carbon metabolism of healthy women compared to food folate. Annals of Nutrition and Metabolism. 67. 248-248.
Status: Publicerad
Hefni, M.E., Shalaby, M.T., Witthöft, C.M. (2015). Folate content in faba beans (Vicia faba L.) - effects of cultivar, maturity stage, industrial processing, and bioprocessing. Food Science & Nutrition. 3 (1). 65-73.
Status: Publicerad
Hefni, M.E., Witthöft, C.M. (2014). Folate content in processed legume foods commonly consumed in Egypt. Lebensmittel-Wissenschaft + Technologie. 57 (1). 337-343.
Status: Publicerad
Büttner, B.E., Witthöft, C.M., Domellöf, M., Hernell, O., Öhlund, I. (2014). Effect of type of heat treatment of breastmilk on folate content and pattern.. Breastfeeding Medicine. 9 (2). 86-91.
Status: Publicerad
Büttner, B.E., Öhrvik, V.E., Köhler, P., Witthöft, C.M., Rychlik, M. (2013). Quantification of isotope-labeled and unlabeled folates and folate catabolites in urine samples by stable isotope dilution assay.. International Journal for Vitamin and Nutrition Research. 83 (2). 112-121.
Status: Publicerad
Hefni, M.E., Witthöft, C.M. (2012). Effect of germination and subsequent oven-drying on folate content in different wheat and rye cultivars. Journal of Cereal Science. 56 (2). 374-378.
Status: Publicerad
Hefni, M.E., Witthöft, C.M. (2012). Enhancement of the folate content in Egyptian pita bread.. Food & Nutrition Research. 56.
Status: Publicerad
Bouckaert, K.P., Slimani, N., Nicolas, G., Vignat, J., Wright, A.J.A., et al. (2011). Critical evaluation of folate data in European and international databases : recommendations for standardization in international nutritional studies.. Molecular Nutrition & Food Research. 55 (1). 166-180.
Status: Publicerad
Hefni, M.E., Witthöft, C.M. (2011). Increasing the folate content in Egyptian baladi bread using germinated wheat flour. Lebensmittel-Wissenschaft + Technologie. 44 (3). 706-712.
Status: Publicerad
Öhrvik, V.E., Witthöft, C.M. (2011). Human folate bioavailability. Nutrients. 3 (4). 475-490.
Status: Publicerad
Büttner, B.E., Öhrvik, V.E., Witthöft, C.M., Rychlik, M. (2011). Quantification of isotope-labelled and unlabelled folates in plasma, ileostomy and food samples.. Analytical and Bioanalytical Chemistry. 399 (1). 429-439.
Status: Publicerad
Öhrvik, V., Öhrvik, H., Tallkvist, J., Witthöft, C.M. (2010). Folates in bread : retention during bread-making and in vitro bioaccessibility. European Journal of Nutrition. 49 (6). 365-372.
Status: Publicerad
Gurinović, M., Witthöft, C.M., Tepšić, J., Ranić, M., Hulshof, P.J.M., et al. (2010). Capacity development in food composition database management and nutritional research and education in Central and Eastern European, Middle Eastern and North African countries.. European Journal of Clinical Nutrition. 64 Suppl 3. S134-S138.
Status: Publicerad
Öhrvik, V.E., Büttner, B.E., Rychlik, M., Lundin, E., Witthöft, C.M. (2010). Folate bioavailability from breads and a meal assessed with a human stable-isotope area under the curve and ileostomy model.. American Journal of Clinical Nutrition. 92 (3). 532-538.
Status: Publicerad
Hefni, M.E., Öhrvik, V., Tabekha, M., Witthöft, C.M. (2010). Folate content in foods commonly consumed in Egypt. Food Chemistry. 121 (2). 540-545.
Status: Publicerad
Gurinovic, M.A., Oshaug, A., Finglas, P., Glibetic, M., Witthöft, C.M., et al. (2009). Capacity building in food composition data base in central and eastern Europe, Middle east and North Africa countries : Successful collaboration between EUROFIR and other networks. Annals of Nutrition and Metabolism. 55 (Supplement 1). 565-565.
Status: Publicerad
Augustin, K., Frank, J., Augustin, S., Langguth, P., Öhrvik, V., et al. (2009). Green tea extracts lower serum folates in rats at very high dietary concentrations only and do not affect plasma folates in a human pilot study.. Journal of Physiology and Pharmacology. 60 (3). 103-108.
Status: Publicerad
Pavlovic, M., Witthöft, C.M., Hollman, P., Hulshof, P.J.M., Glibetic, M., et al. (2009). Training and capacity building in central and eastern Europe through the EuroFIR and CEE networks. Food Chemistry. 113 (3). 846-850.
Status: Publicerad
Öhrvik, V.E., Olsson, J.C., Sundberg, B.E., Witthöft, C.M. (2009). Effect of 2 pieces of nutritional advice on folate status in Swedish women : a randomized controlled trial.. American Journal of Clinical Nutrition. 89 (4). 1053-1058.
Status: Publicerad
Hollman, P.C.H., Witthöft, C.M., Busstra, M.C., Elburg, L., Hulshof, P. (2009). Training aspects in the use and production of food composition databases. The EuroFIR experience. Food Chemistry. 113 (3). 842-845.
Status: Publicerad
Van Guelpen, B., Hultdin, J., Johansson, I., Witthöft, C.M., Weinehall, L., et al. (2009). Plasma folate and total homocysteine levels are associated with the risk of myocardial infarction, independently of each other and of renal function. Journal of Internal Medicine. 266 (2). 182-195.
Status: Publicerad
Öhrvik, V., Witthöft, C.M. (2008). Orange juice is a good folate source in respect to folate content and stability during storage and simulated digestion. European Journal of Nutrition. 47 (2). 92-98.
Status: Publicerad
Öhrvik, V., Witthöft, C.M. (2007). Can foods naturally high in folate improve folate status? : Results from an intervention trial. Annals of Nutrition and Metabolism. 51 (suppl 1). 204-204.
Status: Publicerad
Witthöft, C.M., Arkbåge, K., Johansson, M., Lundin, E., Berglund, G., et al. (2006). Folate absorption from folate-fortified and processed foods using a human ileostomy model.. British Journal of Nutrition. 95 (1). 181-187.
Status: Publicerad
Van Guelpen, B., Hultdin, J., Johansson, I., Stegmayr, B., Hallmans, G., et al. (2005). Folate, vitamin B12, and risk of ischemic and hemorrhagic stroke : a prospective, nested case-referent study of plasma concentrations and dietary intake.. Stroke. 36 (7). 1426-1431.
Status: Publicerad
Verwei, M., Arkbåge, K., Groten, J.P., Witthöft, C.M., Vandenberg, H., et al. (2005). The effect of folatebinding proteins on bioavailability of folate from milk products. Trends in Food Science & Technology. 16 (6-7). 307-310.
Status: Publicerad
Havenaar, R., Verwei, M., Olivares, A.B., Arkbage, K., Ros, G., et al. (2003). Folate bioaccessibility from various food products studied in a dynamic in vitro gastrointestinal model.. Journal of Nutrition. 133 (11). 3862S-3863S.
Status: Publicerad
Strålsjö, L.M., Witthöft, C.M., Sjöholm, I.M., Jägerstad, M.I. (2003). Folate content in strawberries (Fragaria x ananassa) : effects of cultivar, ripeness, year of harvest, storage, and commercial processing.. Journal of Agricultural and Food Chemistry. 51 (1). 128-133.
Status: Publicerad
Verwei, M., Arkbåge, K., Havenaar, R., Van Den Berg, H., Schaafsma, G., et al. (2003). Folic acid and 5-methyltetrahydrofolate in fortified milk are bioaccessible as determined in a dynamic in vitro gastrointestinal model.. Journal of Nutrition. 133 (7). 2377-2383.
Status: Publicerad
Arkbåge, K., Witthöft, C.M., Fonden, R., Jägerstad, M. (2003). Retention of vitamin B-12 during manufacture of six fermented dairy products using a validated radio protein-binding assay. International Dairy Journal. 13 (2-3). 101-109.
Status: Publicerad
Arkbåge, K., Verwei, M., Havenaar, R., Witthöft, C.M. (2003). Bioaccessibility of folic acid and (6S)-5-methyltetrahydrofolate decreases after the addition of folate-binding protein to yogurt as studied in a dynamic in vitro gastrointestinal model.. Journal of Nutrition. 133 (11). 3678-3683.
Status: Publicerad
Strålsjö, L., Åhlin, H., Witthöft, C.M., Jastrebova, J. (2003). Folate determination in Swedish berries by radioprotein-binding assay (RPBA) and high performance liquid chromatography (HPLC). European Food Research and Technology. 216 (3). 264-269.
Status: Publicerad
Jastrebova, J., Witthöft, C.M., Grahn, A., Svensson, U., Jagerstad, M. (2003). HPLC determination of folates in raw and processed beetroots. Food Chemistry. 80 (4). 579-588.
Status: Publicerad
Witthöft, C.M., Strålsjö, L., Berglund, G., Lundin, E. (2003). A human model to determine folate bioavailability from food: A pilot study for evaluation. Scandinavian Journal of Nutrition/Næringsforskning. 47 (1). 6-18.
Status: Publicerad
Johansson, M., Witthöft, C.M., Bruce, A., Jägerstad, M. (2002). Study of wheat breakfast rolls fortified with folic acid : The effect on folate status in women during a 3-month intervention. European Journal of Nutrition. 41 (6). 279-286.
Status: Publicerad
Finglas, P.M., Witthöft, C.M., Vahteristo, L., Wright, A.J.A., Southon, S., et al. (2002). Use of an oral/intravenous dual-label stable-isotope protocol to determine folic acid bioavailability from fortified cereal grain foods in women.. Journal of Nutrition. 132 (5).
Status: Publicerad
Strålsjö, L., Arkbåge, K., Witthöft, C.M., Jägerstad, M. (2002). Evaluation of a radioprotein-binding assay (RPBA) for folate analysis in berries and milk. Food Chemistry. 79 (4). 525-534.
Status: Publicerad
Johannesson, L.M., Witthöft, C.M., Jägerstad, M. (2002). Folate content in strawberries - Effects of storage, ripeness and cultivar. Acta Horticulturae. 567. 809-812.
Status: Publicerad
Forssén, K.M., Jägerstad, M.I., Wigertz, K., Witthöft, C.M. (2000). Folates and dairy products : a critical update.. Journal of the American College of Nutrition (Print). 19 (2 Suppl). 100S-110S.
Status: Publicerad
Witthöft, C.M., Forssén, K., Johannesson, L., Jägerstad, M. (1999). Folates - Food sources, analyses, retention and bioavailability. Scandinavian Journal of Nutrition/Næringsforskning,. 43 (4). 138-146.
Status: Publicerad
Maunder, P., Finglas, P.M., Mallet, A.I., Mellon, F.A., Razzaque, M.A., et al. (1999). The synthesis of folic acid, multiply labelled with stable isotopes, for bio-availability studies in human nutrition. Journal of the Chemical Society-Perkin Transactions 1. (10). 1311-1323.
Status: Publicerad
Finglas, P.M., Wigertz, K., Vahteristo, L., Witthöft, C.M., Southon, S., et al. (1999). Standardisation of HPLC techniques for the determination of naturally-occurring folates in food. Food Chemistry. 64 (2). 245-255.
Status: Publicerad
Vahteristo, L., Finglas, P.M., Witthöft, C.M., Wigertz, K., Seale, R., et al. (1996). Third EU MAT intercomparison study on food folate analysis using HPLC procedures. Food Chemistry. 57 (1). 109-111.
Status: Publicerad

Artikel i tidskrift (Övrigt vetenskapligt)

Åkesson, A., Söderlund, F., Bärebring, L., Christensen, J.J., Olsen, T., et al. (2023). Preparatory work for the update of the tolerable upper intake levels for folic acid/folate. EFSA Supporting Publications. 20 (5).
Status: Publicerad

Artikel i tidskrift (Övrigt (populärvetenskap, debatt))

Carlsson, G., Röös, E., Stephan, A., Tidåker, P., Witthöft, C.M. (2018). ”Ät hälften så mycket kött och mer ärtor och bönor”. Dagens Nyheter.
Status: Publicerad

Kapitel i bok, del av antologi (Refereegranskat)

Hefni, M.E., Witthöft, C.M. (2016). Egyptian Legumes and Cereal Foods : Traditional and New Methods for Processing. Mediterranean Foods : Composition and Processing. Boca Raton, FL, CRC Press. 102-120.
Witthöft, C.M., Hefni, M.E. (2016). Folic acid and Folates : Physiology and Health Effects. The Encyclopedia of Food and Health. Elsevier. 724-730.

Kapitel i bok, del av antologi (Övrigt vetenskapligt)

Witthöft, C.M. (2011). Vitamins : Folates. Encyclopedia of Dairy Sciences. Academic Press. 678-686.
Witthöft, C.M. (2011). Analytical Methods to Assess the Bioavailability of Water-Soluble Vitamins in Food : Exemplified by Folate. Fortified Foods with Vitamins : Analytical Concepts to Assure Better and Safer Products. Wiley-VCH Verlagsgesellschaft. 21-36.

Konferensbidrag (Refereegranskat)

Witthöft, C.M., Jägerstad, M., Bitsch, I. (1999). Folate content and bioavailability in food using HPLC-methods and a human model. VITAMINE UND ZUSATZSTOFFE IN DER ERNAHRUNG VON MENSCH UND TIER. 109-114.
Drachner, S., Witthöft, C.M., Bitsch, I. (1995). The bioavailability of 5-CHO-tetrahydrofolic acid in man. VITAMINS AND ADDITIVES IN HUMAN AND ANIMAL NUTRITION. 288-291.
Hensel, A., Witthöft, C.M., Bitsch, I. (1995). HPLC analytic of food folates (4.EU MAT folate program). VITAMINS AND ADDITIVES IN HUMAN AND ANIMAL NUTRITION. 296-299.

Rapport (Övrigt (populärvetenskap, debatt))

Fridolfsson, E., Augustsson, A., Forss, J., Larsson, P., Waldenström, J., et al. (2021). Förstudie kring hållbar vattenförsörjning i södra Sverige. Linnéuniverstitetet. 17.

Konstnärlig output (Övrigt (populärvetenskap, debatt))

Hadziabdic, E., Brodén, K., Lilja, Å., Bratt, A.S., Sandgren, A., et al. (2024). ohållbart många ohälsosamma haikus om hållbar hälsa. Linnaeus University Press.
Seriealbum med haikus och illustrationer på temat Hållbar hälsa
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