Michael Lindberg
Professor
Institutionen för kemi och biomedicin
Fakulteten för hälso- och livsvetenskap
Jag undervisar i ämnena cell- och molekylärbiologi, genteknik, mikrobiologi samt virologi och leder en forskargrupp som studerar hur virus från familjen Picornavirus växelverkar med den infekterade cellen. I min forskning strävar jag efter att använda ett evolutionsbiologiskt synsätt.
Publikationer
Artikel i tidskrift (Refereegranskat)
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Kirdok, E., Kashuba, N., Damlien, H., Manninen, M.A., Nordqvist, B., et al. (2024). Metagenomic analysis of Mesolithic chewed pitch reveals poor oral health among stone age individuals. Scientific Reports. 13 (1).
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Vandesande, H., Edman, K., Rondahl, E., Falkeborn, T., Serrander, L., et al. (2021). Saffold virus infection in elderly people with acute gastroenteritis in Sweden. Journal of Medical Virology. 93 (6). 3980-3984.
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Vandesande, H., Laajala, M., Kantoluoto, T., Ruokolainen, V., Lindberg, A.M., et al. (2020). Early Entry Events in Echovirus 30 Infection. Journal of Virology. 94 (13). 1-15.
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Simmonds, P., Gorbalenya, A.E., Harvala, H., Hovi, T., Knowles, N.J., et al. (2020). Recommendations for the nomenclature of enteroviruses and rhinoviruses. Archives of Virology. 165. 793-797.
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Turkki, P., Laajala, M., Stark, M., Vandesande, H., Sallinen-Dal Maso, H., et al. (2019). Slow Infection due to Lowering the Amount of Intact versus Empty Particles Is a Characteristic Feature of Coxsackievirus B5 Dictated by the Structural Proteins. Journal of Virology. 93 (20). 1-15.
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Zell, R., Delwart, E., Gorbalenya, A.E., Hovi, T., King, A.M.Q., et al. (2017). ICTV Virus Taxonomy Profile : Picornaviridae. Journal of General Virology. 98 (10). 2421-2422.
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Sävneby, A., Luthman, J., Nordenskjold, F., Andersson, B., Lindberg, A.M. (2016). The Transcriptome of Rhabdomyosarcoma Cells Infected with Cytolytic and Non-Cytolytic Variants of Coxsackievirus B2 Ohio-1. PLOS ONE. 11 (10).
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Mullapudi, E., Novacek, J., Palkova, L., Kulich, P., Lindberg, A.M., et al. (2016). Structure and Genome Release Mechanism of the Human Cardiovirus Saffold Virus 3. Journal of Virology. 90 (17). 7628-7639.
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Sabin, C., Fuzik, T., Skubnik, K., Palkova, L., Lindberg, A.M., et al. (2016). Structure of Aichi Virus 1 and Its Empty Particle : Clues to Kobuvirus Genome Release Mechanism. Journal of Virology. 90 (23). 10800-10810.
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Jonsson, N., Sävneby, A., Gullberg, M., Evertsson, K., Klingel, K., et al. (2015). Efficient replication of recombinant Enterovirus B types, carrying different P1 genes in the coxsackievirus B5 replicative backbone. Virus genes. 50 (3). 351-357.
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Zhu, L., Wang, X., Ren, J., Porta, C., Wenham, H., et al. (2015). Structure of Ljungan virus provides insight into genome packaging of this picornavirus. Nature Communications. 6.
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Israelsson, S., Sävneby, A., Ekström, J., Jonsson, N., Edman, K., et al. (2014). Improved replication efficiency of echovirus 5 after transfection of colon cancer cells using an authentic 5' RNA genome end methodology. Investigational new drugs. 32 (6). 1063-1070.
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Jääskeläinen, A.J., Kolehmainen, P., Voutilainen, L., Hauffe, H.C., Kallio-Kokko, H., et al. (2013). Evidence of ljungan virus specific antibodies in humans and rodents, Finland.. Journal of Medical Virology. 85 (11). 2001-2008.
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Persson, M., Gullberg, M., Tolf, C., Lindberg, A.M., Månsson, A., et al. (2013). Transportation of Nanoscale Cargoes by Myosin Propelled Actin Filaments. PLOS ONE. 8 (2).
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El Hiar, R., Haddad, S., Jaidane, H., Hober, D., Ben M'hadheb-Gharbi, M., et al. (2012). Enteroviral Central Nervous System Infections in Children of the Region of Monastir, Tunisia : Diagnosis, Laboratory Findings of Cerebrospinal Fluid and Clinical Manifestations. Indian Journal of Virology. 23 (3). 294-302.
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Lysholm, F., Wetterbom, A., Lindau, C., Darban, H., Bjerkner, A., et al. (2012). Characterization of the viral microbiome in patients with severe lower respiratory tract infections, using metagenomic sequencing. PLOS ONE. 7 (2).
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Jonsson, N., Wahlström, K., Svensson, L., Serrander, L., Lindberg, A.M. (2012). Aichi virus infection in elderly people in Sweden.. Archives of Virology. 157 (7). 1365-1369.
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Israelsson, S., Jonsson, N., Gullberg, M., Lindberg, A.M. (2011). Cytolytic replication of echoviruses in colon cancer cell lines. Virology Journal. 8.
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Stoltz, M., Sundström, K.B., Hidmark, Å., Tolf, C., Vene, S., et al. (2011). A model system for in vitro studies of bank vole borne viruses. PLOS ONE. 6 (12).
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Gullberg, M., Tolf, C., Jonsson, N., Mulders, M.N., Savolainen-Kopra, C., et al. (2010). Characterization of a putative ancestor of coxsackievirus B5.. Journal of Virology. 84. 9695-9708.
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Israelsson, S., Gullberg, M., Jonsson, N., Roivainen, M., Edman, K., et al. (2010). Studies of Echovirus 5 interactions with the cell surface: Heparan sulfate mediates attachment to the host cell.. Virus Research. 151 (2). 170-176.
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Gullberg, M., Tolf, C., Jonsson, N., Polacek, C., Precechtelova, J., et al. (2010). A single coxsackievirus B2 capsid residue controls cytolysis and apoptosis in rhabdomyosarcoma cells.. Journal of Virology. 84 (12). 5868-5879.
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Tolf, C., Gullberg, M., Ekström, J., Jonsson, N., Lindberg, A.M. (2009). Identification of Ljungan virus VP0 and VP1 amino acid residues associated with cytolytic replication in cultured cells. Archives of Virology. 154 (8). 1271-1284.
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Tolf, C., Gullberg, M., Johansson, E.S., Tesh, R.B., Andersson, B., et al. (2009). Molecular characterization of a novel Ljungan virus (Parechovirus; Picornaviridae) reveals a fourth genotype and indications of ancestral recombination. Journal of General Virology. 90. 843-853.
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Jonsson, N., Gullberg, M., Lindberg, A.M. (2009). Real-time polymerase chain reaction as a rapid and efficient alternative to estimation of picornavirus titers by tissue culture infectious dose 50% or plaque forming units. Microbiology and immunology. 53 (3). 149-154.
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Kim, M., Kim, M., Kwon, Y., Lindberg, A.M., Joh, S., et al. (2009). Development of duck hepatitis A virus type 3 vaccine and its use to protect ducklings against infections. Vaccine. 27 (8). 6688-6694.
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Carlsson, B., Lindberg, A.M., Rodrigues-Díaz, J., Hedlund, K., Persson, B., et al. (2009). Quasispecies dynamics and molecular evolution of human norovirus capsid P region during chronic infection. Journal of General Virology. 90 (2). 432-441.
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Jonsson, N., Gullberg, M., Israelsson, S., Lindberg, A.M. (2009). A rapid and efficient method for studies of virus interaction at the host cell surface using enteroviruses and real-time PCR. Virology Journal. 6 (Article ID: 217).
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Nix, W.A., Maher, K., Johansson, E.S., Niklasson, B., Lindberg, A.M., et al. (2008). Detection of all known parechoviruses by real-time PCR.. Journal of clinical microbiology. 46 (8). 2519-24.
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Kim, M., Kwon, Y., Joh, S., Kwon, J., Lindberg, A.M. (2008). Differential diganosis between type-specific DHV-1 and recent Korean DHV-1 like isolates using a multiplex polymerase chain reaction. Avian Pathology. 37. 171-177.
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Tolf, C., Ekström, J., Gullberg, M., Arbrandt, G., Niklasson, B., et al. (2008). Characterization of polyclonal antibodies against the capsid proteins of Ljungan virus. Journal of Virological Methods. 150 (1-2). 34-40.
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Ekström, J., Tolf, C., Edman, K., Lindberg, A.M. (2007). Physicochemical properties of the Ljungan virus virion in different environments: inactivated by heat but resistant th acidic pH, detergents, and non-physiological environments such as Virkon® containing soulutions. Microbiology and immunology. 51. 841-850.
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Kim, M., Kwon, Y., Joh, S., Kim, S., Tolf, C., et al. (2007). Recent Korean isolates of duck hepatitis virus reveal the presence of a novel geno- and serotype comparing to duck hepatitis virus type 1 strains. Archives of Virology. 152. 2059-2072.
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Ekström, J., Tolf, C., Fahlgren, C., Johansson, S., Arbrandt, G., et al. (2007). Replication of Ljungan virus in cell culture: The genomic 5'-end, infectious cDNA clones and host cell response to viral infections. Virus Research. 130 (December 2007). 129-139.
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Kim, M., Kwon, Y., Joh, S., Lindberg, A.M., Kwon, J., et al. (2006). Molecular analysis of duck hepatitis virus type 1 reveals a novel lineage close to the genus Parechovirus in the family Picornaviridae. Journal of general virology. 87. 3307-3316.
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Au, G.G., Lindberg, A.M., Barry, R.D., Shafren, D.R. (2005). Oncolysis of vascular malignant human melanoma tumors by Coxsackievirus A21.. International Journal of Oncology. 26 (6). 1471-6.
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Johannesson, P., Israelsson, S., Edman, K., Lindberg, A.M. (2005). A novel and rapid method to quantify cytolytic replication of picornaviruses in cell culture. Journal of virological methods. 130. 117-123.
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Polacek, C., Ekström, J., Lundgren, A., Lindberg, A.M. (2005). Cytolytic replication of coxsackievirus B2 in CAR-deficient rhabdomyosarcoma cells.. Virus Research. 113 (2). 107-15.
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Thoelen, I., Moës, E., Lemey, P., Mostmans, S., Wollants, E., et al. (2004). Analysis of the Serotype and Genotype Correlation of VP1 and the 5’ Noncoding Region in and Epidemiological Survey of the Human Enterovirus B Species. Journal of clinical microbiology. 42. 963-971.
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Johansson, S., Ekström, J., Shafren, D., Frisk, G., Hyypiä, T., et al. (2004). Cell culture propagation and biochemical analysis of the Ljungan virus prototype strain. Biochemical and Biophysical Research Communication. 317 (4). 1023-1029.
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Newcombe, N.G., Johansson, E.S., Au, G., Lindberg, A.M., Barry, R.D., et al. (2004). Enterovirus capsid interactions with decay-accelerating factor mediate lytic cell infection. Journal of Virology. 78 (3). 1431-9.
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Thoelen, I., Moës, E., Lemey, P., Mostmans, S., Wollants, E., et al. (2004). Analysis of the serotype and genotype correlation of VP1 and the 5' noncoding region in an epidemiological survey of the human enterovirus B species. Journal of Clinical Microbiology. 42 (3). 963-971.
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Ylipaasto, P., Klingel, K., Lindberg, A.M., Otonkoski, T., Kandolf, R., et al. (2004). Enterovirus infection in human pancreatic islet cells, islet tropism in vivo and receptor involvement in cultured beta-cells. Diabetologia. 47. 225-239.
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Ylipaasto, P., Klingel, K., Lindberg, M.A., Otonkoski, T., Kandolf, R., et al. (2004). Enterovirus infection in human pancreatic islet cells, islet tropism in vivo and receptor involvement in cultured islet beta cells.. Diabetologia. 47 (2). 225-239.
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Niklasson, B., Heller, K.E., Schønecker, B., Bildsøe, M., Daniels, T., et al. (2003). Development of type 1 Diabetes in Wild Bank Voles Associated With Islet Autoantibodies and the Novel Ljungan Virus. International journal of experimental diabetes research. 4. 35-44.
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Lindberg, A.M., Andersson, P., Savolainen, C., Mulders, M.N., Hovi, T. (2003). Evolution of Human Enterovirus B genomes: incongruence between phylogenies of the VP1 and 3CD regions indicates frequent recombination within the species. Journal of general virology. 84. 1223-1235.
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Thoelen, I., Lemey, P., Van Der Donck, I., Beuselinck, K., Lindberg, A.M., et al. (2003). Molecular typing and epidemiology of enteroviruses identified from an outbreak of aseptic meningitis in Belgium during the summer of 2000.. Journal of Medical Virology. 70 (3). 420-9.
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Ekström, J., Andersson, P., Edman, K., Widell, A., Lindberg, A.M. (2003). Genetic and phylogenetic analyses of a coxsackievirus B (CVB) clinical isolate that can be neutralized by CVB4 and CVB5 monospecific antisera. Infection, genetics and evolution. 2. 218-219.
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Thoelen, I., Lemey, P., Van Der Donck, I., Beuselinck, K., Lindberg, A.M., et al. (2003). Molecular Typing and Epidemiology of Enteroviruses Identified from an Outbreak of Aseptic Meningitis in Belgium During the Summer 2000. Journal of medical virology. 70. 343-349.
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Newcombe, N.G., Andersson, P., Johansson, E.S., Au, G.G., Lindberg, A.M., et al. (2003). Cellular receptor interactions of C-cluster human group A coxsackieviruses.. Journal of General Virology. 84 (Pt 11). 3041-3050.
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Johansson, E.S., Niklasson, B., Tesh, R.B., R Shafren, D., Travassos Da Rosa, A.P.A., et al. (2003). Molecular characterization of M1146, an American isolate of Ljungan virus (LV) reveals the presence of a new LV genotype. Journal of general virology. 84. 837-844.
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Selinka, H., Wolde, A., Pasch, A., Klingel, K., Schnorr, J., et al. (2002). Comparative Analysis of Two Coxsackievirus B3 Strains: Putative Influence of Virus-Receptor Interaction on Pathogenesis. Journal of medical virology. 67. 224-233.
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Lindberg, M., Johansson, S. (2002). Phylogenetic analysis of Ljungan virus and A-2 plaque virus, new members of the Picornaviridae. Virus Research. 85 (1). 61-70.
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Andersson, P., Edman, K., Lindberg, A.M. (2002). Molecular analysis of the echovirus 18 prototype. Virus research. 85. 71-83.
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Johansson, S., Niklasson, B., Maizel, J., Gorbalenya, A., Lindberg, M. (2002). Molecular analysis of three Ljungan virus isolates reveals a new, close-to-root lineage of the Picornaviridae with a cluster of two unrelated 2A proteins. Journal of Virology. 76 (17). 8920-8930.
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Thoelen, I., Magnusson, C., Tågerud, S., Polacek, C., Lindberg, A.M., et al. (2001). Identification of Alternative Splice Products Encoded by the Human Coxsackie- Adenovirus Receptor Gene. Biochemical and biophysical research communications. 287. 216-222.
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Thoelen, I., Keyaerts, E., Lindberg, A.M., Van Ranst, M. (2001). Characterization of a cDNA Encoding the Bovine Coxsackie and Adenovirus Receptor.. Biochemical and biophysical research communications. 288. 205-208.
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Lindberg, A.M. (2001). Molecular analysis of the group B coxsackievirus genomes. Infectious disease reviews. 2. 232-233.
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Polacek, C., Lindberg, A.M. (2001). Genetic characterization of the coxsackievirus B2 3’ untranslated region. Journal of general virology. 82. 1339-1348.
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Lindberg, A.M., Polacek, C. (2000). Molecular analysis of the prototype coxsackievirus B5 genome. Archives of Virology. 145. 205-221.
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Frisk, G., Lindberg, A.M., Diderholm, H. (1999). Persistence of Coxsackievirus B4 infection in rhabdomyosarcoma cells for 30 months. Archives of Virology. 144. 2239-2245.
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Lindberg, A.M., Johansson, S., Andersson, A. (1999). Echovirus 5 : infectious transcripts and complete nucleotide sequence from uncloned cDNA. Virus Research. 59 (1). 75-87.
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Lindberg, A.M., Andersson, A. (1999). Purification of full-length enterovirus cDNA by solid phase hybridization capture facilitates amplification of complete genomes. Journal of virological methods. 77. 131-137.
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Polacek, C., Lundgren, A., Andersson, A., Lindberg, A.M. (1999). Genomic and phylogenetic characterization of coxsackievirus B2 prototype strain Ohio-1. Virus research. 59. 229-238.
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Lindberg, A.M., Gräslund, T., Nilsson, J., Uhlén, M., Nygren, P. (1997). Production of a Thermostable DNA Polymerase by Site-Specific Cleavage of a Heat-Eluted Affinity Fusion Protein. Protein expression and purification. 9. 125-132.
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Lindberg, A.M., Polacek, C., Johansson, S. (1997). Amplification and cloning of complete enterovirus by long distance PCR. Journal of virological methods. 65. 191-199.
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Lindberg, M., Polacek, C., Johansson, S. (1997). Amplification and cloning of complete enterovirus genomes by long distance PCR. Journal of Virological Methods. 65 (2). 191-199.
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Liljas, L., Lindberg, A.M., Pettersson, U. (1993). Modelling of the tertiary Structure of Coxsackievirus B3 from the Structure of Poliovirus and Rhinovirus. Scandinavian journal of infectious diseases. Supplement 88. 15-24.
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Lindberg, A.M., Crowell, R., Zell, R., Kandolf, R., Pettersson, U. (1992). Mapping of the RD phenotype of the Nancy strain of coxsackievirus B3. Virus research. 24. 187-196.
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Alksnis, M., Lindberg, A.M., Stålhanske, P., Hultberg, H., Pettersson, U. (1989). Use of synthetic oligodeoxyribonucleotides for type-specific identification of coxsackie B viruses. Molecular and Cellular Probes. 3 (2). 103-108.
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Lindberg, A.M., Stålhanske, P., Pettersson, U. (1987). Genome of Coxsackievirus B3. Virology. 156 (1). 50-63.
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Stålhanske, P., Lindberg, A.M., Pettersson, U. (1984). Replicase Gene of Coxsackievirus B3. Journal of Virology. 51 (3). 742-746.
Status: Publicerad
Konferensbidrag (Refereegranskat)
- Johansson, S., Lindberg, M. (2001). Molecular characterization of Ljungan virus. .
- Lindberg, M., Andersson, P. (2001). Interserotypic recombination and the chimeric nature of coxsackievirus B4 strain E2. 6th International Symposium on Positive Strand RNA Viruses, Paris, France.
- Selinka, H., Wolde, A., Pasch, A., Küpper, J., Klingel, K., et al. (2000). Differential interactions of two coxsackievirus B3 variants with CAR- and DAF-receptor proteins : Implications for binding and infection. EUROPIC 2000: XIth Meeting, Baia dele Zagare, Italy.
- Polacek, C., Lindberg, M. (2000). Generation of wild type-like revertants upon transfection with a 3' end deletion mutant of coxsackievirusw B2 Ohio-1. EUROPIC 2000: XIth Meeting, Baia delle Zagare, Italy.
- Johansson, S., Niklasson, B., Svensson, B., Elfström, T., Tesh, R., et al. (2000). Molecular characterization of Ljungan virus strains - "new" members of the Picornaviridae. EUROPIC 2000: XIth Meeting, Baia delle Zagare, Italy.
- Niklasson, B., Johansson, S., Elfström, T., Lindberg, M. (1999). Ljunganvirus, a previously unrecognized picornavirus and its presence in humans. XIth International Congress of Virology, Sydney Convention Center, Australia, 9-13 August 1999 : Abstracts.
- Lindberg, M. (1999). Molecular analysis of picornaviruses and their receptors. PCR User Forum, Stockholm, Sweden.
- Polacek, C., Andersson, A., Lindberg, M. (1998). Genetic analysis of the prototype strain of coxsackievirus B2 Ohio-1. EUROPIC 98: Jena, Germany.
- Johansson, S., Lindberg, M., Kinnunen, L., Hyypiä, T., Niklasson, B. (1998). Ljungan virus: Genome analysis, genetic diversity and phylogenetic relationship to members of Picornaviridae. .
- Polacel, C., Nilsson, A., Lindberg, M. (1997). Characterization of the structural genes of the prototype strain of coxsackievirus B2 and a variant adapted to growth in rhabdomyosarcoma cells. .
- Johansson, S., Nilsson, A., Ohlson, S., Lindberg, A. (1997). Towards studies of interactions between echovirus 7 and the receptor on human cells: sequence analysis of an infectious full-length clone. 12th International Symposium on Affinity Interactions: Fundamentals and Applications of Biomolecular Recognition, Kalmar, Sweden.
- Nilsson, A., Lindberg, M. (1997). Echovirus 5 : sequence analysis of the complete genome and phylogenetic relationship to other enteroviruses. .
- Polacek, C., Johansson, S., Nilsson, A., Ohlson, S., Lindberg, A.M. (1996). Reverse transcription and long distance enterovirus specific polymerase chain reaction (LDE-PCR) generates complete and infectious enterovirus cDNA genomes. .
- Polacek, C., Nilsson, A., Lindberg, A.M. (1996). Study of tissue tropism using a cloned infectious full length cDNA derived from coxsackievirus B2 strain Ohio-1. .
- Lindberg, A.M., Nilsson, A. (1996). Complete amplification of enterovirus genomes by long distance enterovirus-specific PCR (LDE-PCR) and the "Kalmar Collection" of infectious cDNA clones. .
- Johansson, S., Polacek, C., Nilsson, A., Ohlson, S., Lindberg, A.M. (1996). Studies of weak-to-moderate virus-receptor interactions using uncloned viruses as well as an infectious cDNA clone of echovirus 7 strain Wallace. .
- Lindberg, A.M., Polacel, C. (1995). An efficient strategy for RT-PCR cloning of complete enterovirus sequences. .
- Lindberg, A.M. (1994). Generation of full-length single stranded cDNAs from various types of enteroviruses. EUROPIC 94: VIIIth Meeting, Korpilampi, Finland.
- Lindberg, M. (1993). Identifiering av mutationer i typ B3 coxsackievirusets arvsmassa, vilka förändrar virusets vävnadstropism : Av betydelse för myokarditdiagnostik?. .
- Lindberg, A.M., Pettersson, U. (1989). Correlation between amino acid conservation in the P1 region of coxsackievirus type B and a model of the three dimensional structure of coxsackievirus B3. .
- Lindberg, A.M., Alksnis, M., Stålhandske, P., Pettersson, U. (1987). Molecular biology of coxsackievirus. .
- Lindberg, M. (1986). Molecular biology of coxsackie B virus serotype 3. .
Kapitel i bok, del av antologi (Refereegranskat)
- Knowles, N.J., Hovi, T., Hyypiä, T., King, A.M.Q., Lindberg, A.M., et al. (2012). Family - Picornaviridae. Virus Taxonomy : Ninth Report of the International Committee on Taxonomy of Viruses. San Diego - London, Elsevier. 855-881.
Konferensbidrag (Övrigt vetenskapligt)
- Lindström, T., Lindberg, A.M., Nammari, D.R., Stolte, W. (2004). Nonlinear Deterministic modelling of ecological communuities - typical predictions and limitations. Proceedings of ECO-TECH' 03, RFVs UTVECKLINGSSATSNING DEPONERING 2.
Manuskript (Övrigt vetenskapligt)
- Sävneby, A., Lysholm, F., Jonsson, N., Edman, K., Allander, T., et al. Restricted replication of the rhinovirus C34 prototype in standard cell lines.
- Vandesande, H., Edman, K., Rondahl, E., Falkeborn, T., Serrander, L., et al. Saffold virus infection in elderly people with acutegastroenteritis in Sweden.
- Sävneby, A., Jonsson, N., Svensson, P.A., Hafenstein, S., Lindberg, A.M. Virus derived from an Enterovirus B construct efficiently reverts from a frameshift mutation immediately beyond the translation initiation site.
- Lindberg, A.M., Vandesande, H., Edman, K., Allander, T., Andersson, B. Genetic analysis and limited replication properties of therhinovirus C34 prototype.
- Sävneby, A., Luthman, J., Nordenskjöld, F., Andersson, B., Lindberg, A.M. Gene expression in rhabdomyosarcoma cells infected with cytolytic and non-cytolytic variants of coxsackievirus B2 Ohio.
- Israelsson, S., Ekström, J., Göransson, A., Jonsson, N., Lindberg, A.M. Significance of an authentic 5´ genomic end for activation of viral replication using in vitro transcripts of echovirus 5 and its implication for the efficacy of oncolytic infectious nucleic acid.
Manuskript (Övrigt (populärvetenskap, debatt))
- Ekström, J., Tolf, C., Edman, K., Lindberg, M. A novel mechanism for maturation of the VP1 protein of Ljungan virus.