Per Nilsson
Lektor, biträdande
Institutionen för kemi och biomedicin
Fakulteten för hälso- och livsvetenskap
+46480446126
45027, Hus Vita, Kalmar
Science outreach
Forskare lärde fyrorna mer om blod. Artikel i Smålandsposten 24 januari 2018 om Per Nilssons besök på Ingelstad skola under Science Outreach-dagen.
Mina forskargrupper och projekt
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Linnaeus University Centre for Biomaterials Chemistry Linnéuniversitetets spetsforskningsgrupp inom området biomaterialkemi arbetar med utveckling och tillämpning av material som kan efterlikna och/ell…
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Host Response to Biomaterials Laboratory (HoRB) I forskargruppen Host Response to Biomaterials Laboratory studerar vi de reaktioner som uppkommer vid kontakt mellan blod och för kroppen främmande bioma…
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Projekt: Biomaterialinducerad tromboinflammation – patofysiologiska mekanismer i humant blod vid kontakt med konstgjorda material Syftet med projektet är att kartlägga de biologiska reaktioner som upps…
Publikationer
Publikationer i urval
- Nilsson, P.H., Nilsson Ekdahl, K., Magnusson, P.U., Qu, H., Iwata, H., et al. (2013). Autoregulation of thromboinflammation on biomaterial surfaces by a multicomponent therapeutic coating. Biomaterials. 34. 985-994.
- Berg, A., Otterdal, K., Patel, S., Gonca, M., David, C., et al. (2015). Complement Activation Correlates With Disease Severity and Contributes to Cytokine Responses in Plasmodium falciparum Malaria.. Journal of Infectious Diseases. 212. 1835-1840.
- Otterdal, K., Portillo, A., Astrup, E., Ludviksen, J., Davì, G., et al. (2016). High serum CXCL10 in Rickettsia conorii infection is endothelial cell mediated subsequent to whole blood activation.. Cytokine. 83. 269-274.
- Harboe, M., Johnson, C., Nymo, S., Ekholt, K., Schjalm, C., et al. (2017). Properdin binding to complement activating surfaces depends on initial C3b deposition. Proceedings of the National Academy of Sciences of the United States of America. 114. E534-E539.
- Otterdal, K., Portillo, A., Astrup, E., Ludviksen, J.K., Schjalm, C., et al. (2016). Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo.. Clinical Microbiology and Infection. 22. 734.e1-734.e6.
- Nilsson, P.H., Engberg, A.E., Bäck, J., Faxälv, L., Lindahl, T., et al. (2010). The creation of an antithrombotic surface by apyrase immobilization. Biomaterials. 31. 4484-4491.
Artikel i tidskrift (Refereegranskat)
- Orrem, H.L., Shetelig, C., Ueland, T., Limalanathan, S., Nilsson, P.H., et al. (2018). Soluble IL-1 receptor 2 is associated with left ventricular remodelling in patients with ST-elevation myocardial infarction. International Journal of Cardiology. 268. 187-192.
- Thomas, A.M., Schjalm, C., Nilsson, P.H., Lindenskov, P.H.H., Rørtveit, R., et al. (2018). Combined Inhibition of C5 and CD14 Attenuates Systemic Inflammation in a Piglet Model of Meconium Aspiration Syndrome.. Neonatology. 113. 322-330.
- Orrem, H.L., Nilsson, P.H., Pischke, S.E., Kleveland, O., Yndestad, A., et al. (2018). IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction. Frontiers in Immunology. 9.
- Orrem, H.L., Nilsson, P.H., Pischke, S.E., Grindheim, G., Garred, P., et al. (2018). Acute heart failure following myocardial infarction : complement activation correlates with the severity of heart failure in patients developing cardiogenic shock.. ESC Heart Failure. 5. 292-301.
- Nilsson, P.H., Johnson, C., Pischke, S.E., Fure, H., Landsem, A., et al. (2017). Characterization of a novel whole blood model for the study of thrombin in complement activation and inflammation. Molecular Immunology. 89. 136-137.
- Bergseth, G., Nilsson, P.H., Thomas, A.M., Gustavsen, A., Volokhina, E.B., et al. (2017). Neoepitope based assays to detect C5a – Pitfalls and interpretations. Molecular Immunology. 89. 201-201.
- Harboe, M., Johnson, C., Nymo, S., Ekholt, K., Schjalm, C., et al. (2017). Properdin binding to complement activating surfaces depends on initial C3b deposition. Proceedings of the National Academy of Sciences of the United States of America. 114. E534-E539.
- Wibroe, P.P., Anselmo, A.C., Nilsson, P.H., Sarode, A., Gupta, V., et al. (2017). Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes.. Nature Nanotechnology. 12. 589-594.
- Orrem, H.L., Nilsson, P.H., Pischke, S.E., Kleveland, O., Ekholt, K., et al. (2017). The IL-6 receptor inhibitor tocilizumab attenuated expression of C5a receptor 1 and 2 in patients with myocardial infarction. Molecular Immunology. 89. 128-128.
- Shahini, N., Michelsen, A.E., Nilsson, P.H., Ekholt, K., Gullestad, L., et al. (2017). The alternative complement pathway is dysregulated in patients with chronic heart failure. Scientific Reports. 7. 1-10.
- Barratt-Due, A., Pischke, S.E., Nilsson, P.H., Espevik, T., Mollnes, T.E. (2017). Dual inhibition of complement and Toll-like receptors as a novel approach to treat inflammatory diseases-C3 or C5 emerge together with CD14 as promising targets.. Journal of Leukocyte Biology. 101. 193-204.
- Shahini, N., Michelsen, A.E., Nilsson, P.H., Ekholt, K., Gullestad, L., et al. (2017). The alternative complement pathway is dysregulated in patients with chronic heart failure. Molecular Immunology. 89. 127-127.
- Nilsson, P.H., Thomas, A.M., Bergseth, G., Gustavsen, A., Volokhina, E.B., et al. (2017). Eculizumab-C5 complexes express a C5a neoepitope in vivo : Consequences for interpretation of patient complement analyses. Molecular Immunology. 89. 111-114.
- Thomas, A.M., Schjalm, C., Nilsson, P.H., Lindenskov, P.H.H., Rørtveit, R., et al. (2017). Combined inhibition of C5 and CD14 attenuates systemic inflammation in a newborn pig-model of meconium aspiration syndrome. Molecular Immunology. 89. 166-167.
- Nymo, S., Gustavsen, A., Nilsson, P.H., Lau, C., Espevik, T., et al. (2016). Human Endothelial Cell Activation by Escherichia coli and Staphylococcus aureus Is Mediated by TNF and IL-1 beta Secondarily to Activation of C5 and CD14 in Whole Blood. Journal of Immunology. 196. 2293-2299.
- Otterdal, K., Portillo, A., Astrup, E., Ludviksen, J.K., Schjalm, C., et al. (2016). Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo. Immunobiology. 221. 1204-1205.
- Otterdal, K., Portillo, A., Astrup, E., Ludviksen, J., Davì, G., et al. (2016). High serum CXCL10 in Rickettsia conorii infection is endothelial cell mediated subsequent to whole blood activation.. Cytokine. 83. 269-274.
- Orrem, H.L., Nilsson, P.H., Barratt-Due, A., Pische, S.E., Grindheim, G., et al. (2016). Complement activation in acute heart failure following myocardial infarction. Immunobiology. 221. 1203-1204.
- Harboe, M., Johnson, C., Nymo, S., Ekholt, K., Schjalm, C., et al. (2016). Molecular modelling showed optimal fit between TSR5 in trimeric properdin and C345C in the C3b moiety for stabilization of the alternative convertase, whereas binding to molecular patterns in myeloperoxidase, endothelial cells and Neisseria meningitides was indirectly mediated by initial C3 activation. Immunobiology. 221. 1205-1205.
- Otterdal, K., Portillo, A., Astrup, E., Ludviksen, J.K., Schjalm, C., et al. (2016). Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo.. Clinical Microbiology and Infection. 22. 734.e1-734.e6.
- Fretland, A.A., Sokolov, A., Postriganova, N., Kazaryan, A.M., Pischke, S.E., et al. (2015). Inflammatory Response After Laparoscopic Versus Open Resection of Colorectal Liver Metastases : Data From the Oslo-CoMet Trial.. Medicine (Baltimore, Md.). 94. 1-7.
- Engberg, A.E., Nilsson, P.H., Huang, S., Fromell, K., Hamad, O.A., et al. (2015). Prediction of inflammatory responses induced by biomaterials in contact with human blood using protein fingerprint from plasma. Biomaterials. 36. 55-65.
- Harboe, M., Nilsson, P.H., Johnson, C., Lindstad, J.K., Pharo, A., et al. (2015). Binding of properdin to myeloperoxidase and Neisseria meningitidis is C3-dependent. Molecular Immunology. 67. 142-142.
- Berg, A., Otterdal, K., Patel, S., Gonca, M., David, C., et al. (2015). Complement Activation Correlates With Disease Severity and Contributes to Cytokine Responses in Plasmodium falciparum Malaria.. Journal of Infectious Diseases. 212. 1835-1840.
- Nilsson, P.H., Berg, A., Otterdal, K., Patel, S., Gonca, M., et al. (2014). Complement-dependent inflammatory response Plasmodium-derived hemozoin in malaria. Molecular Immunology. 61. 230-230.
- Huber-Lang, M., Barratt-Due, A., Pischke, S.E., Sandanger, Ø., Nilsson, P.H., et al. (2014). Double blockade of CD14 and complement C5 abolishes the cytokine storm and improves morbidity and survival in polymicrobial sepsis in mice.. Journal of Immunology. 192. 5324-5331.
- Nilsson, P.H., Nilsson Ekdahl, K., Magnusson, P.U., Qu, H., Iwata, H., et al. (2013). Autoregulation of thromboinflammation on biomaterial surfaces by a multicomponent therapeutic coating. Biomaterials. 34. 985-994.
- Mollnes, T.E., Nilsson, P.H. (2013). Letter to the Editor.. Journal of clinical biochemistry and nutrition. 52. 253-254.
- Ehrnthaller, C., Huber-Lang, M., Nilsson, P.H., Bindl, R., Redeker, S., et al. (2013). Complement C3 and C5 deficiency affects fracture healing.. PLoS ONE. 8.
- Mollnes, T., Baratt-Due, A., Pischke, S., Sandanger, I., Nilsson, P.H., et al. (2013). Double-blockade of CD14 and complement component C5 abolish the inflammatory storm and improve survival in mouse polymicrobial sepsis. Molecular Immunology. 56. 294-294.
- Hamad, O.A., Nilsson, P.H., Lasaosa, M., Ricklin, D., Lambris, J.D., et al. (2010). Contribution of Chondroitin Sulfate A to the Binding of Complement Proteins to Activated Platelets. PLoS ONE. 5.
- Hamad, O., Nilsson, P.H., Wouters, D., Lambris, J., Nilsson Ekdahl, K., et al. (2010). Complement Component C3 Binds to Activated Normal Platelets without Preceding Proteolytic Activation and Promotes Binding to Complement Receptor 1. Journal of Immunology. 184. 2686-2692.
- Nilsson, P.H., Engberg, A.E., Bäck, J., Faxälv, L., Lindahl, T., et al. (2010). The creation of an antithrombotic surface by apyrase immobilization. Biomaterials. 31. 4484-4491.
- Hamad, O., Nilsson, P.H., Lambris, J.D., Nilsson Ekdahl, K., Nilsson, B. (2009). Binding of complement proteins to activated platelets is independent of complement activation. Molecular Immunology. 46. 2853-2853.
- Hamad, O.A., Nilsson Ekdahl, K., Nilsson, P.H., Andersson, J., Magotti, P., et al. (2008). Complement activation triggered by chondroitin sulfate reelased by thrombin receptor-activated platelets. Journal of Thrombosis and Haemostasis. 6. 1413-1421.
Konferensbidrag (Refereegranskat)
- Hamad, O., Bäck, J., Nilsson, P.H., Nilsson, B., Nilsson Ekdahl, K. (2012). Platelets, Complement, and Contact Activation : Partners in inflammation and thrombosis. Current Topics in Innate Immunity II. 185-205.
Kapitel i bok, del av antologi (Refereegranskat)
- Mahmoudi, M., Nilsson, P.H., Mollnes, T.E., Roos, D., Sullivan, K.E. (2017). Complement Deficiencies. Primary Immunodeficiency Diseases : Definition, Diagnosis, and Management. Berlin, Heidelberg, Springer. 437-460.
Artikel, forskningöversikt (Refereegranskat)
- Nilsson Ekdahl, K., Lambris, J., Elwing, H., Ricklin, D., Nilsson, P.H., et al. (2011). Innate immunity activation on biomaterial surfaces: A mechanistic model and coping strategies. Advanced Drug Delivery Reviews. 63. 1042-1050.
Artikel i tidskrift (Övrigt vetenskapligt)
- Mohlin, C., Petrus-Reurer, S., Lanner, F., Sandholm, K., Nilsson, P.H., et al. (2018). Is the polarized secretion of complement factor H of importance in age-related macular degeneration?. Investigative Ophthalmology and Visual Science. 59.
- Thomas, A.M., Gerogianni, A., Barratt-Due, A., Mcadam, M.B., Mollnes, T.E., et al. (2018). Complement (C5)-inhibition attenuates heme-induced inflammation in human whole blood. Molecular Immunology. 102. 220-220.
- Nilsson, P.H., Johnson, C., Pischke, S.E., Fure, H., Landsem, A., et al. (2017). Characterization of a novel whole blood model for the study of thrombin in complement activation and inflammation. Molecular Immunology. 89. 136-137.
- Engberg, A.E., Nilsson, P.H., Sandholm, K., Huang, S., Mollnes, T.E., et al. (2013). The ratio between C4 and C4BP adsorbed to artificial materials is a new predictor for biocompatibility. Molecular Immunology. 56. 309-309.
- Engberg, A.E., Nilsson, P.H., Mollnes, T.E., Rosengren-Holmberg, J.P., Nicholls, I.A., et al. (2012). The ratio between C4 and C4BP adsorbed from plasma predicts cytokine generation induced by artificial polymers in contact with whole blood. Immunobiology. 217. 1211-1211.
- Huang, S., Nilsson, P.H., Sandholm, K., Elmlund, L., Nicholls, I.A., et al. (2012). Regulation of complement in whole blood by heparin molecularly imprinted polymer particles. Immunobiology. 217. 1199-1199.
- Teramura, Y., Nilsson, P.H., Nilsson Ekdahl, K., Magnusson, P.U., Qu, H., et al. (2012). Autoregulation of thromboinflammation on biomaterials and cells by a novel therapeutic coating technique. Immunobiology. 217. 1140-1140.
Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
- Nilsson, P.H. (2012). Interactions between platelets and complement with implications for the regulation at surfaces. Doctoral Thesis. Växjö, Kalmar, Linnaeus University Press. 87.
Manuskript (Övrigt vetenskapligt)
- Engberg, A.E., Rosengren-Holmberg, J.P., Nilsson, P.H., Bäck, ., Mollnes, T.E., et al. EVALUATION OF THE HEMOCOMPATIBILITY OF NOVEL POLYMERIC MATERIALS.