Sebastian Lungu-Mitea
Lektor, biträdandeEducation:
- BSc in Molecular Biosciences (Heidelberg University, Germany)
- MSc in Molecular Biosciences, Major in Ecology and Evolution (Heidelberg University, Germany)
- PhD in In Vitro Toxicology (SLU Uppsala, Sweden)
- Postgraduate specialisation in Environmental Toxicology (SETAC-GLB)
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Utbildning:
- BSc i molekylär biovetenskap (Heidelbergs universitet, Tyskland)
- MSc i molekylär biovetenskap, huvudämne ekologi och evolution (Heidelbergs universitet, Tyskland)
- Doktorsexamen i in vitro toxikologi (SLU Uppsala, Sverige)
- Specialisering på forskarnivå i miljötoxikologi (SETAC-GLB)
Undervisning
My teaching activities comprise the following subjects:
- Environmental Toxicology
- Toxicology and Pharmacology
- Cell Biology
- Cancer Cell Biology
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Mina undervisningsaktiviteter omfattar följande ämnen:
- Miljötoxikologi
- Toxikologi och farmakologi
- Cellbiologi
- Cancercellbiologi
Forskning
In terms of research, my work focuses on the development of novel toxicological in vitro test systems within the context of “Tox21” (toxicology testing in the 21st century). In particular, I deal with the establishment of report gene assays for toxicity pathways of emerging interest via classical or CrisprCas-mediated transgenesis. Furthermore, my work includes the development and addition of biotransformation systems within in vitro test scenarios.
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När det gäller forskning är mitt arbete inriktat på utveckling av nya toxikologiska in vitro-analyssystem inom ramen för "Tox21" (toxicology testing in the 21st century). Jag arbetar framför allt med att etablera testsystem för toxicitetsvägar av framväxande intresse via klassisk eller CrisprCas-medierad transgenes. Dessutom omfattar mitt arbete utveckling och tillägg av biotransformationssystem inom in vitro-testscenarier.
Publikationer
Artikel i tidskrift (Refereegranskat)
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Kumari, P., Lungu-Mitea, S., Novak, J., Hilscherova, K. (2025). Advancing in vitro assessment of iodide uptake inhibition : integrating a novel biotransformation pretreatment step. Archives of Toxicology.
Status: Epub för tryck -
Lungu-Mitea, S., Han, Y., Lundqvist, J. (2023). Development, scrutiny, and modulation of transient reporter gene assays of the xenobiotic metabolism pathway in zebrafish hepatocytes. Cell Biology and Toxicology. 39. 991-1013.
Status: Publicerad -
Zhao, H., Li, H., Du, J., Di Mauro, G., Lungu-Mitea, S., et al. (2021). Regulation of ddb2 expression in blind cavefish and zebrafish reveals plasticity in the control of sunlight-induced DNA damage repair. PLOS Genetics. 17 (2).
Status: Publicerad -
Lungu-Mitea, S., Vogs, C., Carlsson, G., Montag, M., Frieberg, K., et al. (2021). Modeling Bioavailable Concentrations in Zebrafish Cell Lines and Embryos Increases the Correlation of Toxicity Potencies across Test Systems. Environmental Science and Technology. 55 (1). 447-457.
Status: Publicerad -
Lungu-Mitea, S., Lundqvist, J. (2020). Potentials and pitfalls of transient in vitro reporter bioassays : interference by vector geometry and cytotoxicity in recombinant zebrafish cell lines. Archives of Toxicology. 94 (8). 2769-2784.
Status: Publicerad -
Lundqvist, J., Mandava, G., Lungu-Mitea, S., Lai, F.Y., Ahrens, L. (2019). In vitro bioanalytical evaluation of removal efficiency for bioactive chemicals in Swedish wastewater treatment plants. Scientific Reports. 9.
Status: Publicerad -
Lungu-Mitea, S., Oskarsson, A., Lundqvist, J. (2018). Development of an oxidative stress in vitro assay in zebrafish (Danio rerio) cell lines. Scientific Reports. 8.
Status: Publicerad -
Zhao, H., Di Mauro, G., Lungu-Mitea, S., Negrini, P., Guarino, A.M., et al. (2018). Modulation of DNA Repair Systems in Blind Cavefish during Evolution in Constant Darkness. Current Biology. 28 (20). 3229-3243.
Status: Publicerad
Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
- Lungu-Mitea, S. (2020). Toxicity pathways in zebrafish cell lines : an ecotoxicological perspective on "toxicity testing in the 21st century". Doctoral Thesis. Swedish University of Agricultural Sciences. 87.