Sinisa Bjelic
Docent
Institutionen för kemi och biomedicin
Fakulteten för hälso- och livsvetenskap
Bjelic Lab
Research
We are interested in understanding molecular interactions in biology.
To our help, we use a combined computational and experimental approach; we often start by applying molecular modelling to build proteins or small molecules predicted to interact with a target protein. We follow up our modelling with biochemical validation.
We have a FACS instrument (BD Melody) that is available for flow cytometry analysis or sorting. If you are at the faculty or the university and are interested in using the instrument within a project, you can contact us above.
For opportunities in the lab, research interests, etc., please visit our website
Teaching
I am involved in teaching biochemistry at the undergraduate level, where I'm also the course responsible and examiner. We also supervise students at the undergraduate and graduate levels on experimental or theoretical projects (protein design and engineering) carried out in our lab. Check for past projects and publications below.
Publikationer
Publikationer i urval
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Bjelic, S., Maganhi, S.H., Friedman, R. (2025). Unveiling the Catalytic Mechanism of Abl1 Kinase : A Single-Magnesium Ion Pathway for Phosphoryl Transfer. Biochemistry. 64 (6). 1415-1424.
Status: Publicerad -
Sjöström, D.J., Grill, B., Ambrosetti, E., Veetil, A.A., Mohlin, C., et al. (2023). Affinity Maturated Transferrin Receptor Apical Domain Blocks Machupo Virus Glycoprotein Binding. Journal of Molecular Biology. 435 (20).
Status: Publicerad -
Sjöström, D.J., Mohlin, C., Ambrosetti, E., Garforth, S.J., Teixeira, A.I., et al. (2022). Motif-driven protein binder design towards transferrin receptor helical domain. The FEBS Journal. 289 (10). 2935-2947.
Status: Publicerad
Artikel i tidskrift (Refereegranskat)
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Bjelic, S., Maganhi, S.H., Friedman, R. (2025). Unveiling the Catalytic Mechanism of Abl1 Kinase : A Single-Magnesium Ion Pathway for Phosphoryl Transfer. Biochemistry. 64 (6). 1415-1424.
Status: Publicerad -
Sjöström, D.J., Grill, B., Ambrosetti, E., Veetil, A.A., Mohlin, C., et al. (2023). Affinity Maturated Transferrin Receptor Apical Domain Blocks Machupo Virus Glycoprotein Binding. Journal of Molecular Biology. 435 (20).
Status: Publicerad -
Otsuka, F.A.M., Bjelic, S. (2022). Evaluation of residue variability in a conformation-specific context and during evolutionary sequence reconstruction narrows drug resistance selection in Abl1 tyrosine kinase. Protein Science. 31 (7).
Status: Publicerad -
Sjöström, D.J., Mohlin, C., Ambrosetti, E., Garforth, S.J., Teixeira, A.I., et al. (2022). Motif-driven protein binder design towards transferrin receptor helical domain. The FEBS Journal. 289 (10). 2935-2947.
Status: Publicerad -
Georgoulia, P.S., Bjelic, S. (2021). Prediction of Protein-Protein Binding Interactions in Dimeric Coiled Coils by Information Contained in Folding Energy Landscapes. International Journal of Molecular Sciences. 22 (3). 1-13.
Status: Publicerad -
Sjöström, D.J., Lundgren, A., Garforth, S.J., Bjelic, S. (2021). Tuning the binding interface between Machupo virus glycoprotein and human transferrin receptor. Proteins : Structure, Function, and Bioinformatics. 89 (3). 311-321.
Status: Publicerad -
Georgoulia, P.S., Bjelic, S., Friedman, R. (2020). Deciphering the molecular mechanism of FLT3 resistance mutations. The FEBS Journal. 287 (15). 3200-3220.
Status: Publicerad -
Sjöström, D.J., Berger, S.A., Oberdorfer, G., Bjelic, S. (2020). Computational backbone design enables soluble engineering of transferrin receptor apical domain. Proteins : Structure, Function, and Bioinformatics. 88 (12). 1569-1577.
Status: Publicerad -
Georgoulia, P.S., Todde, G., Bjelic, S., Friedman, R. (2019). The catalytic activity of Abl1 single and compound mutations : Implications for the mechanism of drug resistance mutations in chronic myeloid leukaemia. Biochimica et Biophysica Acta - General Subjects. 1863 (4). 732-741.
Status: Publicerad -
Andre, I., Bjelic, S. (2018). Computational assessment of folding energy landscapes in heterodimeric coiled coils. Proteins : Structure, Function, and Bioinformatics. 86 (7). 790-801.
Status: Publicerad -
Wijma, H.J., Floor, R.J., Bjelic, S., Marrink, S.J., Baker, D., et al. (2015). Enantioselective enzymes by computational design and in silico screening. Angewandte Chemie International Edition. 54 (12). 3726-3730.
Status: Publicerad -
Liu, Y., Zhang, X., Tan, Y.L., Bhabha, G., Ekiert, D.C., et al. (2014). De Novo-Designed Enzymes as Small-Molecule-Regulated Fluorescence Imaging Tags and Fluorescent Reporters. Journal of the American Chemical Society. 136 (38). 13102-13105.
Status: Publicerad -
Bjelic, S., Kipnis, Y., Wang, L., Pianowski, Z., Vorobiev, S., et al. (2014). Exploration of Alternate Catalytic Mechanisms and Optimization Strategies for Retroaldolase Design. Journal of Molecular Biology. 426 (1). 256-271.
Status: Publicerad -
Liu, Y., Tan, Y.L., Zhang, X., Bhabha, G., Ekiert, D.C., et al. (2014). Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts.. Proceedings of the National Academy of Sciences of the United States of America. 111 (12). 4449-4454.
Status: Publicerad -
Nivón, L.G., Bjelic, S., King, C., Baker, D. (2014). Automating human intuition for protein design. Proteins : Structure, Function, and Bioinformatics. 82 (5). 858-866.
Status: Publicerad -
Bjelic, S., Nivón, L.G., Çelebi-Ölçüm, N., Kiss, G., Rosewall, C.F., et al. (2013). Computational design of enone-binding proteins with catalytic activity for the Morita-Baylis-Hillman reaction. ACS Chemical Biology. 8 (4). 749-757.
Status: Publicerad -
Richter, F., Leaver-Fay, A., Khare, S.D., Bjelic, S., Baker, D. (2011). De novo enzyme design using Rosetta3. PLOS ONE. 6 (5).
Status: Publicerad -
Bjelic, S., Brandsdal, B.O., Åqvist, J. (2008). Cold adaptation of enzyme reaction rates. Biochemistry. 47 (38). 10049-10057.
Status: Publicerad -
Bjelic, S., Nervall, M., Gutiérrez-De-Terán, H., Ersmark, K., Hallberg, A., et al. (2007). Computational inhibitor design against malaria plasmepsins. Cellular and Molecular Life Sciences (CMLS). 64 (17). 2285-2305.
Status: Publicerad -
Bjelic, S., Åqvist, J. (2006). Catalysis and linear free energy relationships in aspartic proteases. Biochemistry. 45 (25). 7709-7723.
Status: Publicerad -
Ersmark, K., Feierberg, I., Bjelic, S., Hamelink, E., Hackett, F., et al. (2004). Potent inhibitors of the Plasmodium falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity. Journal of Medicinal Chemistry. 47 (1). 110-122.
Status: Publicerad -
Åqvist, J., Wennerström, P., Nervall, M., Bjelic, S., Brandsdal, B.O. (2004). Molecular dynamics simulations of water and biomolecules wit a Monte Carlo constant pressure algorithm. Chemical Physics Letters. 384 (4-6). 288-294.
Status: Publicerad -
Bjelic, S., Aqvist, J. (2004). Computational prediction of structure, substrate binding mode, mechanism, and rate for a malaria protease with a novel type of active site.. Biochemistry. 43 (46). 14521-14528.
Status: Publicerad -
Ersmark, K., Feierberg, I., Bjelic, S., Hultén, J., Samuelsson, B., et al. (2003). C2-symmetric inhibitors of Plasmodium falciparum plasmepsin II : synthesis and theoretical predictions. Bioorganic & Medicinal Chemistry. 11 (17). 3723-3733.
Status: Publicerad
Artikel, forskningsöversikt (Refereegranskat)
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Friedman, R., Bjelic, S. (2020). Simulations Studies of Protein Kinases that are Molecular Targets in Cancer. Israel Journal of Chemistry. John Wiley & Sons. 60 (7). 667-680.
Status: Publicerad
Artikel i tidskrift (Övrigt vetenskapligt)
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Bjelic, S. (2015). Protein carriers for passage of the Blood-Brain Barrier. Protein Science. 24. 177-177.
Status: Publicerad