Fredag 7 mars kommer Mohammed Hefni och Cornelia Witthöft att föreläsa i institutionen för kemi och biomedicins seminarieserie.
Om seminariet
Trimethylamine N‐oxide (TMAO) is a gut microbiota–dependent metabolite derived from the dietary precursors l‐carnitine and choline, and is recognized as a risk factor for various non‐communicable diseases. Alterations in gut microbiota composition have been observed in metabolic syndrome (MetS), yet it remains unclear how these changes impact circulating TMAO levels and their association with metabolic syndrome features such as body weight, plasma lipids, and blood glucose.
This seminar presents new findings from a clinical trial comparing fasting and postprandial plasma TMAO concentrations in subjects with and without MetS.
By using 16S rRNA sequencing and targeted metabolomics, we show how MetS-associated dysbiosis can affect the microbial conversion of choline and carnitine to trimethylamine, which is subsequently oxidized to TMAO by hepatic flavin monooxygenase 3 after consumption of choline and carnitine rich foods (egg and meat).
Seminariet hålls både på plats i sal Azur, hus Vita i Kalmar, samt via Zoom på den här länken.
Seminariet hålls på engelska.
